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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 21, 2008
Volume 21, No. 7

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These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations
Noskova T, et al.
Prog Neuropsychopharmacol Biol Psychiatry 2008 Jul

 

Infectious and Parasitic Diseases

Apolipoprotein-+AHs-epsilon+AH0-4 and recurrent genital herpes in HSV type 2 and HIV co-infected individuals
Jayasuriya A, et al.
Sex Transm Infect 2008 Aug

Polymorphisms in the C-type Lectin Genes Cluster in Chromosome 19 and Predisposition to SARS-Coronavirus Infection
Li H, et al.
J Med Genet 2008 Aug

 

Neoplasms

Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
Takei K, et al.
BMC Cancer 2008 Aug;8(1):235

Interleukin-10 -1082 promoter polymorphism associated with gastric cancer among Asians
Zhou Y, et al.
Eur J Cancer 2008 Aug

NAT2 fast acetylator genotypes are associated with an increased risk for lung cancer with wildtype epidermal growth factor receptors in Taiwan
Lee CN, et al.
Lung Cancer 2008 Aug

Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay  Area Latinos and African Americans
Chang JS, et al.
Int J Cancer 2008 Aug

Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
Concannon P, et al.
Cancer Res 2008 Aug;68(16):6486-91

Polygenic Model of DNA-Repair Genetic Polymorphisms in Human Breast Cancer Risk
Smith TR, et al.
Carcinogenesis 2008 Aug

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival
Gardner ER, et al.
BJU Int 2008 Aug

A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma
Xu T, et al.
Carcinogenesis 2008 Aug

Mitochondrial DNA variant interactions modify breast cancer risk
Covarrubias D, et al.
J Hum Genet 2008 Aug

Chromosome 17q12 variants contribute to risk of early-onset prostate cancer
Levin AM, et al.
Cancer Res 2008 Aug;68(16):6492-5

Genetic polymorphisms in the paraoxonase 1 gene and risk of ovarian epithelial carcinoma
Lurie G, et al.
Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2070-7

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma
Lan Q, et al.
Blood 2008 Aug

Methylene Tetrahydrofolate Reductase Genotype Modifies the Chemopreventive Effect of Folate in Colorectal Adenoma, but not Colorectal Cancer
Lightfoot TJ, et al.
Cancer Epidemiol Biomarkers Prev 2008 Aug

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women
Novak DJ, et al.
BMC Cancer 2008 Aug;8(1):239

Detection of HPV-DNA, p53 alterations, and methylation in penile squamous cell carcinoma in Japanese men
Yanagawa N, et al.
Pathol Int 2008 Aug;58(8):477-82

Case-Control Analysis of Nucleotide Excision Repair Pathway and the Risk of Renal Cell Carcinoma
Lin J, et al.
Carcinogenesis 2008 Aug

Variants of DNA repair genes and the risk of biliary tract cancers and stones: a  population-based study in china
Zhang M, et al.
Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2123-7

Association of Genetic Variation in Genes Implicated in the +AHs-beta+AH0--Catenin Destruction Complex with Risk of Breast Cancer
Wang X, et al.
Cancer Epidemiol Biomarkers Prev 2008 Aug;17(8):2101-8

The Relative Contribution of Point Mutations and Genomic Rearrangements in BRCA1  and BRCA2 in High-Risk Breast Cancer Families
Palma MD, et al.
Cancer Res 2008 Aug

Genetic polymorphisms in the estrogen receptor beta (ESR2) gene and the risk of epithelial ovarian carcinoma
Lurie G, et al.
Cancer Causes Control 2008 Aug

 

Endocrine, Nutritional and Metabolic Diseases

Genetic Variants Associated with Insulin Resistance and Metabolic Syndrome in Young Asian Indians with Myocardial Infarction
Ranjith N, et al.
Metab Syndr Relat Disord 2008 Aug

Apolipoprotein E3/E3 Genotype Decreases the Risk of Pituitary Dysfunction After Traumatic Brain Injury due to Various Causes: Preliminary Data
Tanriverdi F, et al.
J Neurotrauma 2008 Aug

Interactions between Glutathione S-Transferase P1, Tumor Necrosis Factor, and Traffic-Related Air Pollution for Development of Childhood Allergic Disease
Melen E, et al.
Environ Health Perspect 2008 Aug;116(8):1077-84

111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women
Lee JY, et al.
Fertil Steril 2008 Aug

STAT4: A risk factor for type 1 diabetes?
Zervou MI, et al.
Hum Immunol 2008 Aug

Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: A randomized clinical trial
de Luis DA, et al.
Diabetes Res Clin Pract 2008 Aug

 

Mental Disorders

Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood
Perkins KA, et al.
Behav Pharmacol 2008 Sep;19(5-6):641-9

Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers
Perkins KA, et al.
Behav Pharmacol 2008 Sep;19(5-6):630-40

Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population
Richards M, et al.
J Neural Transm 2008 Aug

Electrodermal reactivity during the Trier Social Stress Test for children: Interaction between the serotonin transporter polymorphism and children's attachment representation
Gilissen R, et al.
Dev Psychobiol 2008 Aug;50(6):615-25

Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes
Srivastava V, et al.
Pharmacogenomics 2008 Aug;9(8):1055-68

Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and  smoking among Polish population: a case-control study
Sieminska A, et al.
BMC Med Genet 2008 Aug;9(1):76

The serotonin transporter gene and personality: association of the 5-HTTLPR s allele, anxiety, depression and affective temperaments
Gonda X
Orv Hetil 2008 Aug;149(33):1569-73

Gene x Environment Interactions at the Serotonin Transporter Locus
Munafo MR, et al.
Biol Psychiatry 2008 Aug

Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment
Crettol S, et al.
Prog Neuropsychopharmacol Biol Psychiatry 2008 Jul

 

Diseases of the Blood & Blood-Forming Organ Disorders

Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and  the Caribbean
Grann VR, et al.
Br J Haematol 2008 Aug

 

Mental Disorders

Association study between reward dependence temperament and a polymorphism in the phenylethanolamine N-methyltransferase gene in a Japanese female population
Yamano E, et al.
Compr Psychiatry 2008 Sep-2008 Oct;49(5):503-7

Association Between the Catechol-O-Methyltransferase Val158Met Polymorphism and Cocaine Dependence
Lohoff FW, et al.
Neuropsychopharmacology 2008 Aug

Neuregulin 3 Genetic Variations and Susceptibility to Schizophrenia in a Chinese  Population
Wang YC, et al.
Biol Psychiatry 2008 Aug

Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: Evidence from a case-control study and meta-analysis
Utsunomiya K, et al.
Neurosci Lett 2008 Aug

Genetic Association of the CHRNA6 and CHRNB3 Genes with Tobacco Dependence in a Nationally Representative Sample
Hoft NR, et al.
Neuropsychopharmacology 2008 Aug

The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese  population
Kishimoto M, et al.
Behav Brain Funct 2008 Aug;4(1):37

Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1)  and fatty acid amide hydrolase (FAAH) genes
Haughey HM, et al.
Addiction 2008 Aug

Diseases of the Nervous System and Sense Organs

The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications
Bialecka M, et al.
Pharmacogenet Genomics 2008 Sep;18(9):815-21

Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population
Zhou YT, et al.
Neurosci Lett 2008 Aug

Genetic Analysis of Interleukin-1A C(-889)T Polymorphism with Alzheimer Disease
Hu JL, et al.
Cell Mol Neurobiol 2008 Aug

Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy
Nakamura S, et al.
Graefes Arch Clin Exp Ophthalmol 2008 Aug

Cognitive effects of memantine in postmenopausal women at risk of dementia: a pilot study
Wroolie TE, et al.
Acta Neurol Scand 2008 Aug

Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexicans patients:  A relationship between HLA and gender is suggested
Alaez C, et al.
BMC Med Genet 2008 Aug;9(1):79

Mitochondrial DNA haplogroups do not influence the Huntington's disease phenotype
Mancuso M, et al.
Neurosci Lett 2008 Aug

Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study
McAllister TW, et al.
Brain Inj 2008 Aug;22(9):705-14

Polymorphisms in the Vascular Endothelial Growth Factor Gene and Risk of Age-Related Macula Degeneration The Rotterdam Study
Boekhoorn SS, et al.
Ophthalmology 2008 Aug

Melanocortin 1 receptor genotype, past environmental sun exposure, and risk of multiple sclerosis
Dwyer T, et al.
Neurology 2008 Aug;71(8):583-9

Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease
Choi JM, et al.
Neurogenetics 2008 Aug

Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration
Kim IK, et al.
Mol Vis 2008;14:1487-95

Diseases of the Circulatory System

Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
Conen D, et al.
J Hypertens 2008 Sep;26(9):1780-6

Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses
Kurnik D, et al.
Pharmacogenet Genomics 2008 Sep;18(9):743-50

+AFs-Analysis of tissue inhibitor of metalloproteinase-2 gene polymorphisms in a caucasian population with abdominal aortic aneurysms.+AF0-
Hinterseher I, et al.
Zentralbl Chir 2008 Aug;133(4):332-7

Lack of Association of Functional Variants in Alpha-ENaC Gene and Essential Hypertension in Two Ethnic Groups in China
Wang XF, et al.
Kidney Blood Press Res 2008 Aug;31(4):268-73

Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in non-diabetic  caucasians
Qasim AN, et al.
Clin Endocrinol (Oxf) 2008 Aug

The Human G147D-Protein Phosphatase 1 Inhibitor-1 Polymorphism Is Not Associated  with Altered Clinical Characteristics in Heart Failure
Chen G, et al.
Cardiology 2008 Aug;112(3):224-31

A mitochondrial mutation A4401G is involved in the pathogenesis of left ventricular hypertrophy in Chinese hypertensives
Zhu HY, et al.
Eur J Hum Genet 2008 Aug

Polymorphisms of the Z protein protease inhibitor and risk of venous thromboembolism: a meta-analysis
Dentali F, et al.
Br J Haematol 2008 Aug

 

Diseases of the Respiratory System

Tumor necrosis factor - alpha and transforming growth factor - beta1 polymorphisms in bronchial asthma
Kumar A, et al.
Indian J Med Sci 2008 Aug;62(8):323-30

Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
Ates I, et al.
Am J Ind Med 2008 Aug

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure
Hosseini-Khalili AR, et al.
BMC Pulm Med 2008 Aug;8(1):15

 

Diseases of the Digestive System

Analysis of association of clinical aspects and vitamin D receptor gene polymorphism with dental implant loss
Alvim-Pereira F, et al.
Clin Oral Implants Res 2008 Aug;19(8):786-95

Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy
Latiano A, et al.
World J Gastroenterol 2008 Aug;14(29):4643-51

Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China
Chen M, et al.
BMC Med Genet 2008 Aug;9(1):78

Effect of MMP-1 promoter polymorphisms on GCF MMP-1 levels and outcome of periodontal therapy in patients with severe chronic periodontitis
Pirhan D, et al.
J Clin Periodontol 2008 Aug

Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk
Ferguson LR, et al.
World J Gastroenterol 2008 Aug;14(29):4652-61

 

Complications of Pregnancy, Childbirth, and the Puerperium

The angiotensinogen gene M235T polymorphism and development of preeclampsia/eclampsia: a meta-analysis and meta-regression of observational studies
Zafarmand MH, et al.
J Hypertens 2008 Sep;26(9):1726-34

Association of Tumor Necrosis Factor-Alpha and Interleukin-10 Gene Polymorphisms  in Iranian Patients with Pre-eclampsia
Mirahmadian M, et al.
Am J Reprod Immunol 2008 Aug;60(2):179-85

 

Diseases of the Skin and Subcutaneous Tissue

Combined effects of HLA-Cw6 and cigarette smoking in psoriasis vulgaris: A hospital-based case-control study in China
Jin Y, et al.
J Eur Acad Dermatol Venereol 2008 Aug

Diseases of the Musculoskeletal System and Connective Tissue

Association of Angiotensin-converting enzyme gene dimorphisms with severity of lupus disease
Rabbani MA, et al.
Saudi J Kidney Dis Transpl 2008 Sep;19(5):761-6

Identification of LTBP2 on Chromosome 14q as a Novel Candidate Gene for Bone mineral Density Variation and Fracture Risk Association
Cheung CL, et al.
J Clin Endocrinol Metab 2008 Aug

SLC22A4 Polymorphism and Rheumatoid Arthritis Susceptibility: A Replication Study in a Japanese Population and a Metaanalysis
Okada Y, et al.
J Rheumatol 2008 Aug

Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis
Park KS, et al.
Tissue Antigens 2008 Aug

 

Congenital Anomalies

Genetic susceptibilities in the association between maternal exposure to tobacco  smoke and the risk of nonsyndromic oral cleft
Chevrier C, et al.
Am J Med Genet A 2008 Aug;146A(18):2396-406

 

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Page last reviewed: August 28, 2008 (archived document)
Content Source: National Office of Public Health Genomics
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