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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
October 11, 2007
Volume 19, No. 15

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These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Frequencies of GSTM1, GSTT1, andGSTP1 polymorphisms in ethnic minority from Guizhou.
Zhang W, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):589-91

Polymorphism of the human platelet alloantigens HPA-3 and HPA-9w in the Chinese  Han population.
Huang H, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):586-8

 

Infectious and Parasitic Diseases

Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26
Gatanaga H, et al.
Clin Infect Dis 2007 Nov;45(9):1230-7

The Association between Mannan-Binding Lectin Gene Polymorphism and Clinical Leprosy: New Insight into an Old Paradigm
de Messias-Reason IJ, et al.
J Infect Dis 2007 Nov;196(9):1379-85

Angiotensin-converting enzyme insertion/deletion polymorphism and risk and outcome of pneumonia
van de Garde EM, et al.
Chest 2007 Oct

CD14-159CC, another risk genotype for severe SARS-CoV infection
Yuan FF, et al.
Clin Vaccine Immunol 2007 Oct

Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media
Emonts M, et al.
Pediatrics 2007 Oct;120(4):814-23

Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease
Gallant CJ, et al.
Genes Immun 2007 Oct

Single nucleotide polymorphisms and functional analysis of class II transactivator (CIITA) promoter IV in persistent HBV infection
Zhang X, et al.
J Clin Virol 2007 Oct

HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection
McAulay KA, et al.
J Clin Invest 2007 Oct;117(10):3042-8

Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients
Hirt D, et al.
Br J Clin Pharmacol 2007 Oct

 

Neoplasms

Clinical implication of vascular endothelial growth factor T-460C polymorphism in the risk and progression of prostate cancer
Fukuda H, et al.
Oncol Rep 2007 Nov;18(5):1155-63

Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population
Kanzaki H, et al.
Oncol Rep 2007 Nov;18(5):1171-5

Is the p53 codon 72 polymorphism a key biomarker for cervical cancer development? A meta-analysis review within European populations
Sousa H, et al.
Int J Mol Med 2007 Nov;20(5):731-41

The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast  cancer
Justenhoven C, et al.
Breast Cancer Res Treat 2007 Oct

Polymorphisms in three base excision repair genes and breast cancer risk in Thai  women
Sangrajrang S, et al.
Breast Cancer Res Treat 2007 Oct

Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans
Huo D, et al.
Breast Cancer Res Treat 2007 Oct

Cytochrome P4501A1 and Microsomal Epoxide Hydrolase Gene Polymorphisms: Gene-Environment Interaction and Risk of Prostate Cancer
Mittal RD & Srivastava DL
DNA Cell Biol 2007 Oct

p53 Codon 72 polymorphism and the risk of esophageal squamous cell carcinoma
Yang W, et al.
Mol Carcinog 2007 Oct

Germline mutations in the CHEK2 kinase gene are associated with an increased risk of bladder cancer
Zlowocka E, et al.
Int J Cancer 2007 Oct

Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness
Sfar S, et al.
Mol Biol Rep 2007 Oct

Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy
Ugurel S, et al.
Cancer Immunol Immunother 2007 Oct

Single nucleotide polymorphisms in selected cytokine genes and risk of adult glioma
Brenner AV, et al.
Carcinogenesis 2007 Oct

Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer
Raaschou-Nielsen O, et al.
Lung Cancer 2007 Oct

Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma
Liu CH, et al.
J Biomed Sci 2007 Oct

Association of RNASEL Variants with Prostate Cancer Risk in Hispanic Caucasians and African Americans
Shook SJ, et al.
Clin Cancer Res 2007 Oct;13(19):5959-64

Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the  risk for esophageal cancer in a Western population
Rossini A, et al.
Carcinogenesis 2007 Oct

The association of XRCC2 gene polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in China.
Wang N, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):538-43

Polymorphisms in manganese superoxide dismutase, myeloperoxidase and glutathione-S-transferase and survival after treatment for metastatic breast cancer
Bewick MA, et al.
Breast Cancer Res Treat 2007 Oct

Do MDM2 SNP309 and TP53 R72P Interact in Breast Cancer Susceptibility? A Large Pooled Series from the Breast Cancer Association Consortium
Schmidt MK, et al.
Cancer Res 2007 Oct;67(19):9584-90

The Impact of Sex and Smoking Status on the Mutational Spectrum of Epidermal Growth Factor Receptor Gene in Non small Cell Lung Cancer
Toyooka S, et al.
Clin Cancer Res 2007 Oct;13(19):5763-8

Genetic variants in cell cycle control pathway confer susceptibility to lung cancer
Wang W, et al.
Clin Cancer Res 2007 Oct;13(19):5974-81

Association Study of 69 Genes in the Ret Pathway Identifies Low-penetrance Loci in Sporadic Medullary Thyroid Carcinoma
Ruiz-Llorente S, et al.
Cancer Res 2007 Oct;67(19):9561-7

 

Endocrine, Nutritional and Metabolic Diseases

Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relatives
Wang JP, et al.
Tissue Antigens 2007 Nov;70(5):369-75

Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus
Yamada Y, et al.
Int J Mol Med 2007 Nov;20(5):703-7

Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population
Kwak SH, et al.
Diabetes Res Clin Pract 2007 Oct

Genetic Study of Saudi Diabetes (GSSD): significant association of the KCNJ11 E23K polymorphism with type 2 diabetes
Alsmadi O, et al.
Diabetes Metab Res Rev 2007 Oct

Genetic polymorphism c.1438A>G of the 5-HT(2A) receptor is associated with abdominal obesity in Chinese Northern Han population
Ying S, et al.
Mol Biol Rep 2007 Oct

The progesterone receptor PROGINS polymorphism is not related to oxidative stress factors in women with polycystic ovary syndrome
Karadeniz M, et al.
Cardiovasc Diabetol 2007 Oct;6(1):29

Food reinforcement, the dopamine D-sub-2 receptor genotype, and energy intake in  obese and nonobese humans
Epstein LH, et al.
Behav Neurosci 2007 Oct;121(5):877-86

TCF7L2 is Not a Major Susceptibility Gene for Type 2 Diabetes in Pima Indians: An Analysis of 3501 Individuals
Guo T, et al.
Diabetes 2007 Oct

 

Diseases of the Blood & Blood-Forming Organ Disorders

Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations
Sebastiani P, et al.
Am J Hematol 2007 Oct

 

Mental Disorders

Evidence of an Association Between the Vasopressin V1b Receptor Gene (AVPR1B) and Childhood-Onset Mood Disorders
Dempster EL, et al.
Arch Gen Psychiatry 2007 Oct;64(10):1189-95

The monoamine oxidase B gene exhibits significant association to ADHD
Li J, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Oct

Relationship of SERT Polymorphisms to Depressive and Anxiety Symptoms in Irritable Bowel Syndrome
Jarrett ME, et al.
Biol Res Nurs 2007 Oct;9(2):161-9

No Association of the G1287A Polymorphism in the Norepinephrine Transporter Gene  and Susceptibility to Major Depressive Disorder in a Japanese Population
Inoue K, et al.
Biol Pharm Bull 2007 Oct;30(10):1996-8

Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder
Lee J, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Oct

Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes
Tolstrup JS, et al.
Pharmacogenomics J 2007 Oct

A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa
Kaplan AS, et al.
Int J Eat Disord 2007 Oct

Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence
Xuei X, et al.
Addict Biol 2007 Oct

 

Diseases of the Nervous System and Sense Organs

Interleukin-10 gene polymorphism in Parkinson's disease patients
Bialecka M, et al.
Arch Med Res 2007 Nov;38(8):858-63

Genetic association analysis of the interleukin 7 gene (IL7) in multiple sclerosis
Lundmark F, et al.
J Neuroimmunol 2007 Oct

Association Study of Human MTH1 Ile45Thr Polymorphism with Sporadic Parkinson's Disease
Jiang G, et al.
Eur Neurol 2007 Oct;59(1-2):15-7

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome  and seizure types: a case-control study
Cavalleri GL, et al.
Lancet Neurol 2007 Oct

Study on correlation between HLA-A, B, DR alleles and Duchenne muscular dystrophy.
Chen W, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):567-70

Genetic Association of Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) With  Alzheimer's Disease
Chen Z, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Oct

Alpha-synuclein promoter haplotypes and dementia in Parkinson's Disease
De Marco EV, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Oct

The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease
Costa-Mallen P, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Oct

Diseases of the Circulatory System

ACE I/D polymorphism in Korean patients with ischemic stroke and silent brain infarction
Hong SH, et al.
Acta Neurol Scand 2007 Oct

Molecular Analysis of Factor V Leiden, Factor V Hong Kong, Factor II G20210A, Methylenetetrahydrofolate Reductase C677T, and A1298C Mutations Related to Turkish Thrombosis Patients
Dolek B, et al.
Clin Appl Thromb Hemost 2007 Oct;13(4):435-8

Candidate Gene Association Studies in Abdominal Aortic Aneurysm Disease: A Review and Meta-Analysis
Thompson AR, et al.
Eur J Vasc Endovasc Surg 2007 Oct

Methylenetetrahydrofolate Reductase TT Genotype as a Predictor of Cardiovascular  Risk in Hypertensive Adolescents
Koo HS, et al.
Pediatr Cardiol 2007 Oct

Microsatellite DNA polymorphism of adrenomedullin gene and atherosclerotic cerebral infarction.
Bi G, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):579-81

Association of -63A/C polymorphism of glutathione S-transferase M3 gene with essential hypertension in Chinese population.
Liu J, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):582-5

Association of APOA5 gene polymorphism with levels of lipids and atherosclerotic cerebral infarction in Chinese.
Li J, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):576-8

 

Diseases of the Digestive System

TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian  cohort
Hong J, et al.
J Gastroenterol Hepatol 2007 Nov;22(11):1760-6

Relationship between genetic polymorphism of MCP-1 and acute pancreatitis in Han population of Suzhou in China.
Nie J & Chen W
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):598-600

HLA DQ Gene Dosage and Risk and Severity of Celiac Disease
Murray JA, et al.
Clin Gastroenterol Hepatol 2007 Oct

Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population
Juzyszyn Z, et al.
Dig Liver Dis 2007 Oct

 

Diseases of the Genitourinary System

DNA repair gene XRCC1 and XPD polymorphisms and the risk of idiopathic azoospermia in a Chinese population
Gu A, et al.
Int J Mol Med 2007 Nov;20(5):743-7

Association between Vitamin D Receptor Gene Polymorphisms and Susceptibility to Chronic Kidney Disease and Periodontitis
Machado de Souza C, et al.
Blood Purif 2007 Oct;25(5):411-9

CA repeat and RsaI polymorphisms in ERbeta gene are not associated with infertility in Indian men
Khattri A, et al.
Int J Androl 2007 Oct

Multiple SOD1/SFRS15 variants are associated with the development and progression of diabetic nephropathy: The DCCT/EDIC Genetics study
Al-Kateb H, et al.
Diabetes 2007 Oct

 

Complications of Pregnancy, Childbirth, and the Puerperium

Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion
Ostojic S, et al.
Am J Reprod Immunol 2007 Nov;58(5):403-8

 

Diseases of the Musculoskeletal System and Connective Tissue

Usefulness of human leucocyte antigen-B27 subtypes in predicting ankylosing spondylitis: Taiwan experience
Hou TY, et al.
Intern Med J 2007 Nov;37(11):749-52

Study on genetic susceptibility of the single nucleotide polymorphism of FCGR3A  gene and systemic lupus erythematosus.
Pan F, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):544-7

The heat shock protein 70-2 gene +1267(A/G)polymorphism and susceptibility to ankylosing spondylitis in Chinese Han population.
Lin J, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):574-5

Association studies of ALOX5 and bone mineral density in healthy adults
Foroud T, et al.
Osteoporos Int 2007 Oct

 

Congenital Anomalies

The relationship between polymorphism of gene involved in folate metabolism, homocysteine level and risk of Down syndrome.
Wang W, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007 Oct;24(5):533-7

 

 

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Page last reviewed: October 11, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics
  Last Updated March 04, 2008