Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 

HugeNet™

Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
July 26, 2007
Volume 19, No. 4

Return to Weekly Update

Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population
Hilli J, et al.
Fundam Clin Pharmacol 2007 Aug;21(4):379-86

Genetic polymorphisms of drug-metabolizing enzymes CYP2D6, CYP2C9, CYP2C19 and CYP3A5 in the Greek population
Arvanitidis K, et al.
Fundam Clin Pharmacol 2007 Aug;21(4):419-26

Determination of ABCB1 polymorphisms and haplotypes frequencies in a French population
Jeannesson E, et al.
Fundam Clin Pharmacol 2007 Aug;21(4):411-8

Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families
Guenard F, et al.
Fam Cancer 2007 Jul

 

Infectious and Parasitic Diseases

Fc gamma Receptor IIa Polymorphism in Patients with Brucellosis
Hashemi Sh, et al.
Jpn J Infect Dis 2007 Aug;60(4):196-7

A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Fellay J, et al.
Science 2007 Jul

 

Neoplasms

Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer
Yang M, et al.
Carcinogenesis 2007 Jul

MDM2 SNP309 Polymorphism as Risk Factor for Susceptibility and Poor Prognosis in Renal Cell Carcinoma
Hirata H, et al.
Clin Cancer Res 2007 Jul;13(14):4123-9

Genetic polymorphisms in the vascular endothelial growth factor gene and breast cancer risk. The Austrian "tumor of breast tissue: incidence, genetics, and environmental risk factors" study
Langsenlehner U, et al.
Breast Cancer Res Treat 2007 Jul

A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma
Sipahimalani P, et al.
Int J Cancer 2007 Jul

Polymorphic TP53BP1 and TP53 Gene Interactions Associated with Risk of Squamous Cell Carcinoma of the Head and Neck
Chen K, et al.
Clin Cancer Res 2007 Jul;13(14):4300-5

Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial
Hubner RA, et al.
Int J Cancer 2007 Jul

Functional Variant of Manganese Superoxide Dismutase (SOD2 V16A) Polymorphism Is Associated with Prostate Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Study
Kang D, et al.
Cancer Epidemiol Biomarkers Prev 2007 Jul

Origin and distribution of the BRCA2-8765delAG mutation in breast cancer
Palomba G, et al.
BMC Cancer 2007 Jul;7(1):132

Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-Inflammatory Cytokine Gene Polymorphisms in Whites: A Nationwide Multicenter Study in Spain
Garcia-Gonzalez MA, et al.
Am J Gastroenterol 2007 Jul

The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral cancer
Vairaktaris E, et al.
Am J Hematol 2007 Jul

GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas
Wideroff L, et al.
Cancer Detect Prev 2007 Jul

 

Endocrine, Nutritional and Metabolic Diseases

Interleukin1{beta} Genetic Polymorphisms Interact with Polyunsaturated Fatty Acids to Modulate Risk of the Metabolic Syndrome
Shen J, et al.
J Nutr 2007 Aug;137(8):1846-51

Effect of the 3'APOB-VNTR polymorphism on the lipid profiles in the Guangxi Hei Yi Zhuang and Han populations
Ruixing Y, et al.
BMC Med Genet 2007 Jul;8(1):45

The role of Melanocortin 3 Receptor Gene in Childhood Obesity
Lee YS, et al.
Diabetes 2007 Jul

The relationship between iron overload and clinical characteristics in a Spanish cohort of 100 C282Y homozygous hemochromatosis patients
Altes A, et al.
Ann Hematol 2007 Jul

A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
Kevenaar ME, et al.
Hum Reprod 2007 Jul

Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
Kilpelainen TO, et al.
Physiol Genomics 2007 Jul

Common STAT3 Variants Are Not Associated With Obesity or Insulin Resistance in Female Twins
Jamshidi Y, et al.
Obesity (Silver Spring) 2007 Jul;15(7):1634-9

Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
Niculescu LS, et al.
Clin Chem Lab Med 2007 Jul

Polymorphisms within the Protein Tyrosine Phosphatase 1B (PTPN1) Gene Promoter: Functional Characterization and Association with Type 2 Diabetes and Related Metabolic Traits
Meshkani R, et al.
Clin Chem 2007 Jul

 

Mental Disorders

Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele
Dorado P, et al.
Fundam Clin Pharmacol 2007 Aug;21(4):451-3

CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy
Friedman JI, et al.
Mol Psychiatry 2007 Jul

COMT ValMet moderation of stress-induced psychosis
Stefanis NC, et al.
Psychol Med 2007 Jul:1-6

Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders
Pae CU, et al.
Psychiatry Res 2007 Jul

 

Diseases of the Nervous System and Sense Organs

Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes
Yue Y, et al.
Acta Pharmacol Sin 2007 Aug;28(8):1129-35

Methylenetetrahydrofolate Reductase C677T Polymorphism and Cognitive Function in Older Women
Elkins JS, et al.
Am J Epidemiol 2007 Jul

The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraine
Pinessi L, et al.
Cephalalgia 2007 Jul

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
Winkelmann J, et al.
Nat Genet 2007 Jul

Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians
Xiong L, et al.
Sleep Med 2007 Jul

Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease
Winkler S, et al.
Eur J Hum Genet 2007 Jul

Association Between a Polymorphism in the Lymphotoxin(-a) Promoter Region and Migraine
Lee KA, et al.
Headache 2007 Jul;47(7):1056-62

Complement C3 Variant and the Risk of Age-Related Macular Degeneration
Yates JR, et al.
N Engl J Med 2007 Jul

Association Analysis of {gamma}2 Subunit of {gamma}-aminobutyric Acid (GABA) Type A Receptor and Voltage-gated Sodium Channel Type II {alpha}-polypeptide Gene Mutation in Southern Chinese Children With Febrile Seizures
Xiumin Wang, et al.
J Child Neurol 2007 Jun;22(6):714-9

Diseases of the Circulatory System

Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts
Alanne M, et al.
Hum Genet 2007 Jul

Genomewide Association Analysis of Coronary Artery Disease
Samani NJ, et al.
N Engl J Med 2007 Jul

A meta-analysis of relationship between beta-fibrinogen gene -148C/T polymorphism and susceptibility to cerebral infarction in Han Chinese
Chen XC, et al.
Chin Med J (Engl) 2007 Jul;120(13):1198-202

Polymorphisms in 33 inflammatory genes and risk of myocardial infarction-a system genetics approach
Barbaux S, et al.
J Mol Med 2007 Jul

Genetic Variation associated with Ischemic Heart Failure: A HuGE Review and Meta-Analysis
Kitsios G & Zintzaras E
Am J Epidemiol 2007 Jul

Variants in the CRP Gene as a Measure of Lifelong Differences in Average C-Reactive Protein Levels: The Cardiovascular Risk in Young Finns Study, 1980 2001
Kivimaki M, et al.
Am J Epidemiol 2007 Jul

The uncoupling protein-1 gene -3826A/G polymorphism and hypertension in Japanese subjects
Kotani K, et al.
Clin Chem Lab Med 2007 Jul

Lymphotoxin-alpha gene 252A>G and metabolic syndrome features in Korean men with coronary artery disease
Jang Y, et al.
Clin Chim Acta 2007 Jul

Platelet glycoprotein Ibalpha polymorphisms and function evaluated by the platelet function analyzer PFA-100 in patients with lupus anticoagulant: the association with thromboembolic disease
Jilma-Stohlawetz P, et al.
Ann Hematol 2007 Jul

 

Diseases of the Respiratory System

The relationship between polymorphisms in the glutamate cysteine ligase gene and asthma susceptibility
Polonikov AV, et al.
Respir Med 2007 Jul

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men
Kokaze A, et al.
J Hum Genet 2007 Jul

The GSTP1 Gene Is a Susceptibility Gene for Childhood Asthma and the GSTM1 Gene Is a Modifier of the GSTP1 Gene
Kamada F, et al.
Int Arch Allergy Immunol 2007 Jul;144(4):275-86

 

Diseases of the Digestive System

Evaluation of the Thyroid Transcription Factor-1 Gene (TITF1) as a Hirschsprung's Disease Locus
Garcia-Barcelo MM, et al.
Ann Hum Genet 2007 Jul

Arg(64) Variant of the beta(3)-Adrenergic Receptor is Associated With Gallstone Formation
Klass DM, et al.
Am J Gastroenterol 2007 Jul

Association of cytokine gene polymorphisms and liver fibrosis in chronic hepatitis B
Chan HL, et al.
J Gastroenterol Hepatol 2007 Jul

 

Diseases of the Genitourinary System

Lack of association between NPHS2 gene polymorphisms and sporadic IgA nephropathy
Mao J, et al.
Nephrology (Carlton) 2007 Aug;12(4):371-5

 

Complications of Pregnancy, Childbirth, and the Puerperium

Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR
Dawood F, et al.
Hum Reprod 2007 Jul

 

Diseases of the Skin and Subcutaneous Tissue

Genetic Variations in NALP1 Are Associated with Generalized Vitiligo in a Romanian Population
Jin Y, et al.
J Invest Dermatol 2007 Jul

 

Congenital Anomalies

The Impact of BRCA1 on Spina Bifida Meningomyelocele Lesions
King TM, et al.
Ann Hum Genet 2007 Jul

 

Symptoms, Signs and Ill-defined Conditions

Polymorphisms in cytokine genes influence long-term survival differently in elderly male and female patients
Cederholm T, et al.
J Intern Med 2007 Aug;262(2):215-23

 

Injury and Poisoning

Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms
Lindberg AL, et al.
Environ Health Perspect 2007 Jul;115(7):1081-6

 

For more information on HuGE, please visit the HuGENet™ home page

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC National Office of Public Health Genomics makes available the above information as a public service only.
Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

Page last reviewed: July 26, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics