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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
March 30, 2006
Volume 16, No. 13

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Infectious and Parasitic Diseases

Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases
Ozturk C, et al.
Clin Exp Med 2006 Mar;6(1):27-32

Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis
Selvaraj P, et al.
FEMS Immunol Med Microbiol 2006 Apr;46(3):433-7

 

Neoplasms

Association of the PDCD5 Locus With Lung Cancer Risk and Prognosis in Smokers
Spinola M, et al.
J Clin Oncol 2006 Mar

Estrogen Receptor {beta} Polymorphism Is Associated with Prostate Cancer Risk
Thellenberg-Karlsson C, et al.
Clin Cancer Res 2006 Mar;12(6):1936-41

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers
Copson ER, et al.
BMC Cancer 2006 Mar;6(1):80

Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
Friedman E, et al.
Breast Cancer Res 2006 Mar;8(2):R15

Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking
Sugio K, et al.
Br J Cancer 2006 Mar;94(6):896-903

A study on the association of MTHFR C677T polymorphism with genetic susceptibility to hepatocellular carcinoma
Zhu ZZ, et al.
Zhonghua Gan Zang Bing Za Zhi 2006 Mar;14(3):196-8

Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study
Dianzani I, et al.
Mutat Res 2006 Mar

Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina
Perez LO, et al.
World J Gastroenterol 2006 Mar;12(9):1426-9

Lack of association between the glutathione-s-transferase genes (GSTT1 and GSTM1) and nasal polyposis
Arbag H, et al.
Rhinology 2006 Mar;44(1):14-8

p53 Codon 72 Polymorphism in Basal Cell Carcinoma of the Skin
Pezeshki A, et al.
Pathol Oncol Res 2006;12(1):29-33

Impact of the Cyclin D1 A870G Polymorphism on Susceptibility to Sporadic Colorectal Cancer in Taiwan
Huang WS, et al.
Dis Colon Rectum 2006 Mar

Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer
Crawford NP, et al.
Breast Cancer Res 2006 Mar;8(2):R16

 

Endocrine, Nutritional and Metabolic Diseases

Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients
Turunen JA, et al.
Immunogenetics 2006 Mar

The Gly146Ala variation in human SF-1 gene: Its association with insulin resistance and type 2 diabetes in Chinese
Liu W, et al.
Diabetes Res Clin Pract 2006 Mar

Lipoprotein lipase gene S447X polymorphism modulates the relation between central obesity and serum lipids, a twin study
Huang AQ, et al.
Int J Obes (Lond) 2006 Mar

 

Mental Disorders

Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects
Li J, et al.
Neurosci Lett 2006 Mar

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
Treutlein J, et al.
Mol Psychiatry 2006 Mar

CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing
Cai WM, et al.
Pharmacogenomics J 2006 Mar

Population-based and family-based association studies of an (AC)n dinucleotide repeat in alpha-7 nicotinic receptor subunit gene and schizophrenia
Fan JB, et al.
Schizophr Res 2006 Mar

Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean spain: a preliminary study
Tabares-Seisdedos R, et al.
Neuroscience 2006 Mar

Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction
Dick DM, et al.
J Stud Alcohol 2006 Mar;67(2):185-94

ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double-blind placebo-controlled crossover study
Shin HY, et al.
Hum Psychopharmacol 2006 Mar

The Role of GABRA2 in Risk for Conduct Disorder and Alcohol and Drug Dependence across Developmental Stages
Dick DM, et al.
Behav Genet 2006 Mar

The G72/G30 Gene Complex and Cognitive Abnormalities in Schizophrenia
Goldberg TE, et al.
Neuropsychopharmacology 2006 Mar

Absence of association of a polymorphic GGC repeat at the 5' untranslated region of the reelin gene with schizophrenia
Huang CH & Chen CH
Psychiatry Res 2006 Mar

N-methyl-d-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels
Martucci L, et al.
Schizophr Res 2006 Mar

 

Diseases of the Nervous System and Sense Organs

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis
Tajouri L, et al.
Brain Res Bull 2006 Apr;69(3):327-31

No association between the brain-derived neurotrophic factor 196G>A or 270C>T polymorphisms and Alzheimer's or Parkinson's disease
Saarela MS, et al.
Folia Neuropathol 2006;44(1):12-6

Association of the Tau haplotype with Parkinson's disease in the Greek population
Fidani L, et al.
Mov Disord 2006 Mar

Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene
Schurks M, et al.
Neurology 2006 Mar

Occupationally sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk
Saadat M & Farvardin-Jahromi M
Occup Environ Med 2006 Mar

Diseases of the Circulatory System

A novel Val734Ile variant in the ABCC9 gene associated with myocardial infarction
Minoretti P, et al.
Clin Chim Acta 2006 Mar

Factor VII Gene Haplotypes and Risk of Ischemic Stroke
Funk M, et al.
Clin Chem 2006 Mar

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
Cohen JC, et al.
N Engl J Med 2006 Mar;354(12):1264-72

The -318 C>G Single-Nucleotide Polymorphism in GNAI2 Gene Promoter Region Impairs Transcriptional Activity through Specific Binding of Sp1 Transcription Factor and Is Associated with High Blood Pressure in Caucasians from Italy
Menzaghi C, et al.
J Am Soc Nephrol 2006 Apr;17(4_suppl_2):S115-S119

The association of oestrogen receptor {alpha}-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study
Lawlor DA, et al.
Eur Heart J 2006 Mar

Paraoxonase gene polymorphisms and haplotype analysis in a stroke population
Pasdar A, et al.
BMC Med Genet 2006 Mar;7(1):28

Anger suppression and adiposity modulate association between ADRB2 haplotype and cardiovascular stress reactivity
Poole JC, et al.
Psychosom Med 2006 Mar-2006 Apr;68(2):207-12

Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene
Kaneda H, et al.
Circ J 2006 Apr;70(4):409-13

Genetic Epidemiology of Intracerebral Hemorrhage
Woo D, et al.
J Stroke Cerebrovasc Dis 2005;14(6):239-43

Angiotensin II type 2 receptor gene polymorphisms and cardioprotective role in essential hypertension
Zhang M, et al.
Heart Vessels 2006 Mar;21(2):95-101

VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection)
Wang Y, et al.
Circulation 2006 Mar

 

 

Diseases of the Respiratory System

Family-Based Association Tests Suggest Linkage Between Surfactant Protein B (SP-B) (and Flanking Region) and Respiratory Distress Syndrome (RDS): SP-B Haplotypes and Alleles From SP-B-Linked Loci Are Risk Factors for RDS
Floros J, et al.
Pediatr Res 2006 Apr;59(4):616-21

 

Diseases of the Digestive System

Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis
Wasmuth HE, et al.
Hepatology 2006 Mar;43(4):738-41

Association between RET proto-oncogene polymorphisms and Hirschsprung disease in Chinese Han population of Hubei district
DU HS, et al.
Zhonghua Wei Chang Wai Ke Za Zhi 2006 Mar;9(2):152-6

Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer
Chakravorty M, et al.
Hum Mutat 2006 Mar

 

Diseases of the Genitourinary System

Paraoxonase 1 192 and 55 polymorphisms in nephrotic children
Biyikli NK, et al.
Pediatr Nephrol 2006 Mar

Phenotypic and genotypic risk factors for cardiovascular events in an incident dialysis cohort
Pernod G, et al.
Kidney Int 2006 Mar

The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease
Testa A, et al.
Nephrol Dial Transplant 2006 Mar

Genetic variation in 11beta}-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism amongst lean women with polycystic ovary syndrome
Gambineri A, et al.
J Clin Endocrinol Metab 2006 Mar

The role of proinflammatory cytokine gene polymorphisms for development of insulin resistance after renal transplantation
Genctoy G, et al.
Transplant Proc 2006 Mar;38(2):521-8

A family-based association study of megsin A23167G polymorphism with susceptibility and progression of IgA nephropathy in a Chinese population
Xia YF, et al.
Clin Nephrol 2006 Mar;65(3):153-9

 

Diseases of the Musculoskeletal System and Connective Tissue

A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population
Sugiura T, et al.
Arthritis Res Ther 2006 Mar;8(3):R60

IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis
Mattyasovszky S, et al.
Arthritis Res Ther 2006 Mar;8(3):R63

Association of Corticosteroids and Factor V, Prothrombin, and MTHFR Gene Mutations With Avascular Osteonecrosis in Renal Allograft Recipients
Celik A, et al.
Transplant Proc 2006 Mar;38(2):512-6

 

Congenital Anomalies

Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population
Parle-McDermott A, et al.
Eur J Hum Genet 2006 Mar

 

Symptoms, Signs and Ill-defined Conditions

Comparative study between the Light Cycler(R) and the PCR-restriction fragment length polymorphism in detecting factor V Leiden and factor II 20210G>A mutations
Mammo L, et al.
Clin Biochem 2006 Mar

Altered Methylprednisolone Pharmacodynamics in Healthy Subjects With Histamine N-Methyltransferase C314T Genetic Polymorphism
Hon YY, et al.
J Clin Pharmacol 2006 Apr;46(4):408-17

Prevention of postoperative nausea and vomiting with granisetron and dolasetron in relation to CYP2D6 genotype
Janicki PK, et al.
Anesth Analg 2006 Apr;102(4):1127-33

Simultaneous Determination of 7 N-Acetyltransferase-2 Sequence Variations by Allele-Specific Primer Extension Assay
Zhu Y, et al.
Clin Chem 2006 Mar

 

Injury and Poisoning

A combined analysis of XRCC1, XRCC3, GSTM1 and GSTT1 polymorphisms and centromere content of micronuclei in welders
Iarmarcovai G, et al.
Mutagenesis 2006 Mar

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics