Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 

HugeNet™

Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
January 26, 2006
Volume 16, No. 4

Return to Weekly Update

Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Infectious and Parasitic Diseases

A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population
Flores C, et al.
Genes Immun 2006 Jan

CCR2 allele polymorphisms in 15 Chinese ethnic populations
Zhang XL, et al.
Int J Immunogenet 2006 Feb;33(1):45-8

 

Neoplasms

Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men()
Bangsi D, et al.
Urol Oncol 2006 Jan-2006 Feb;24(1):21-7

Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)
Cox DG, et al.
Cancer Causes Control 2006 Feb;17(1):81-3

Familial adenomatous polyposis (FAP): Genotype correlation to FAP phenotype with osteomas and sebaceous cysts
Bisgaard ML & Bulow S
Am J Med Genet A 2006 Jan

Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression
Ju H, et al.
Cancer Lett 2006 Jan

Polymorphism in the 3'-untranslated region of the thymidylate synthase gene and sensitivity of stomach cancer to fluoropyrimidine-based chemotherapy
Lu JW, et al.
J Hum Genet 2006 Jan

Genetic Susceptibility to Prostate Cancer: Prostate-specific Antigen and its Interaction with the Androgen Receptor (United States)
Sieh W, et al.
Cancer Causes Control 2006 Mar;17(2):187-97

Meta-analysis of association of rare mutations and common sequence variants in the MSR1 gene and prostate cancer risk
Sun J, et al.
Prostate 2006 Jan

Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer
Slattery ML, et al.
Int J Cancer 2006 Jan

APE1 genotype and risk of bladder cancer: Evidence for effect modification by smoking
Terry PD, et al.
Int J Cancer 2006 Jan

Polymorphic amino acids at codons 9 and 37 of HLA-DQB1 alleles may confer susceptibility to cervical cancer among Chinese women
Wu Y, et al.
Int J Cancer 2006 Jan

A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients
Manenti G, et al.
Carcinogenesis 2006 Jan

Haemochromatosis gene (HFE) mutations in viral-associated neoplasia: Linkage to cervical cancer
Cardoso CS, et al.
Biochem Biophys Res Commun 2006 Jan;341(1):232-8

HER-2
Zubor P, et al.
Neoplasma 2006;53(1):49-55

Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects
Belogubova EV, et al.
J Cancer Res Clin Oncol 2006 Jan:1-5

Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer
Bradbury BD, et al.
J Carcinog 2006 Jan;5(1):3

Association of the PIG3 Promoter Polymorphism with Invasive Bladder Cancer in a Japanese Population
Ito M, et al.
Jpn J Clin Oncol 2006 Jan

Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000
Tryggvadottir L, et al.
J Natl Cancer Inst 2006 Jan;98(2):116-22

Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort
Cheng I, et al.
J Natl Cancer Inst 2006 Jan;98(2):123-34

IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer
Zecevic M, et al.
J Natl Cancer Inst 2006 Jan;98(2):139-43

Profiling Genetic Variation along the Androgen Biosynthesis and Metabolism Pathways Implicates Several Single Nucleotide Polymorphisms and Their Combinations as Prostate Cancer Risk Factors
Mononen N, et al.
Cancer Res 2006 Jan;66(2):743-7

Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer
Cebrian A, et al.
Cancer Res 2006 Jan;66(2):1225-33

Int7G24A Variant of Transforming Growth Factor-{beta} Receptor Type I Is Associated with Invasive Breast Cancer
Chen T, et al.
Clin Cancer Res 2006 Jan;12(2):392-7

Lack of association between the TNF-alpha promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukaemia
Bogunia-Kubik K, et al.
Int J Immunogenet 2006 Feb;33(1):21-4

GSTT1 and M1 polymorphisms in Hurthle thyroid cancer patients
Stankov K, et al.
Cancer Lett 2006 Jan

 

Endocrine, Nutritional and Metabolic Diseases

The Arg121Trp variant in PAX4 gene is associated with beta-cell dysfunction in Japanese subjects with type 2 diabetes mellitus
Tokuyama Y, et al.
Metabolism 2006 Feb;55(2):213-6

Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population
Wang G, et al.
Biochem Biophys Res Commun 2006 Jan

DRD4 gene variant associated with body mass: The National Longitudinal Study of Adolescent Health
Guo G, et al.
Hum Mutat 2006 Jan

CYP21A2 mutations in Portuguese patients with congenital adrenal hyperplasia: Identification of two novel mutations and characterization of four different partial gene conversions
Friaes A, et al.
Mol Genet Metab 2006 Jan

Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups
Akkad DA, et al.
Int J Immunogenet 2006 Feb;33(1):59-61

Endothelial nitric oxide synthase haplotypes affect the susceptibility to hypertension in patients with type 2 diabetes mellitus
Sandrim VC, et al.
Atherosclerosis 2006 Jan

The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians
Mackevics V, et al.
Eur J Hum Genet 2006 Jan

Associations among Race/Ethnicity, ApoC-III Genotypes, and Lipids in HIV-1-Infected Individuals on Antiretroviral Therapy
Foulkes AS, et al.
PLoS Med 2006 Jan;3(3):e52

The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population
Sorli JV, et al.
Clin Chim Acta 2006 Jan

Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein and ischemic heart disease: Cross-sectional, prospective and case-control studies from The Copenhagen City Heart Study
Wittrup HH, et al.
J Clin Endocrinol Metab 2006 Jan

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Grant SF, et al.
Nat Genet 2006 Jan

Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients
Terakura S, et al.
Bone Marrow Transplant 2006 Jan

Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals
Shin HD, et al.
Diabet Med 2006 Jan;23(1):72-6

HLA-DRB1 polymorphism is associated with Kell immunisation
Chiaroni J, et al.
Br J Haematol 2006 Feb;132(3):374-8

 

Diseases of the Blood and Blood-Forming Organs Disorders

The presence of IFNG 3/3 genotype in the recipient associates with increased risk for Epstein-Barr virus reactivation after allogeneic haematopoietic stem cell transplantation
Bogunia-Kubik K, et al.
Br J Haematol 2006 Feb;132(3):326-32

The impact of genetic variation in the region of the GPIIIa gene, on Pl expression bias and GPIIb/IIIa receptor density in platelets
O'halloran AM, et al.
Br J Haematol 2006 Feb;132(4):494-502

 

Mental Disorders

The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men
Pivac N, et al.
Life Sci 2006 Jan

Association between the dopamine D(2) receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males
Denys D, et al.
Eur Neuropsychopharmacol 2006 Jan

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
Sim SC, et al.
Clin Pharmacol Ther 2006 Jan;79(1):103-13

The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients
Ueda M, et al.
Prog Neuropsychopharmacol Biol Psychiatry 2006 Jan

Family-Based Association Test of the 5HTTLPR and Aggressive Behavior in a General Population Sample of Children
Haberstick BC, et al.
Biol Psychiatry 2006 Jan

 

Diseases of the Nervous System and Sense Organs

Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV. Role of dopaminergic pathway gene polymorphisms
Srivastava V, et al.
Pharmacogenet Genomics 2006 Feb;16(2):111-7

Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population
Payton A, et al.
Genes Brain Behav 2006 Feb;5 Suppl 1:23-31

A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease
Harold D, et al.
Pharmacogenet Genomics 2006 Feb;16(2):75-7

Association between Glycogen Synthase Kinase-3beta Genetic Polymorphism and Late-Onset Alzheimer's Disease
Mateo I, et al.
Dement Geriatr Cogn Disord 2006 Jan;21(4):228-32

Genetic Variation in DTNBP1 Influences General Cognitive Ability
Burdick KE, et al.
Hum Mol Genet 2006 Jan

Paraoxonase 1 gene polymorphisms influence clinical features of open-angle glaucoma
Inagaki Y, et al.
Graefes Arch Clin Exp Ophthalmol 2006 Jan:1-7

Is there an association between the COMT gene and P300 endophenotypes?
Bramon E, et al.
Eur Psychiatry 2006 Jan

Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation
Venturin M, et al.
Neurogenetics 2006 Jan:1-8

Genetic study of Sardinian patients with Alzheimer's disease
Piscopo P, et al.
Neurosci Lett 2006 Jan

The apolipoprotein E {varepsilon}4 allele selectively increases the risk of frontotemporal lobar degeneration in males
Srinivasan R, et al.
J Neurol Neurosurg Psychiatry 2006 Feb;77(2):154-8

Further Evidence for an Association of 5-HTTLPR with Intensity Dependence of Auditory-Evoked Potentials
Hensch T, et al.
Neuropsychopharmacology 2006 Jan

Genetic variants of the NOTCH3 gene in migraine-a mutation analysis and association study
Schwaag S, et al.
Cephalalgia 2006 Feb;26(2):158-61

Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia
Shinkai T, et al.
Psychiatry Res 2006 Jan

 

Diseases of the Circulatory System

A nonsense polymorphism (Y319X) of the solute carrier family 6 member 18 (SLC6A18) gene is not associated with hypertension and blood pressure in Japanese
Eslami B, et al.
Tohoku J Exp Med 2006 Jan;208(1):25-31

Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis
Zee RY, et al.
J Thromb Haemost 2006 Feb;4(2):341-8

The CAREGENE study: polymorphisms of the {beta}1-adrenoceptor gene and aerobic power in coronary artery disease
Defoor J, et al.
Eur Heart J 2006 Jan

Plasminogen Activator Inhibitor-1 Gene. Selection of Tagging SNPs and Association With Coronary Heart Disease
Su S, et al.
Arterioscler Thromb Vasc Biol 2006 Jan

SERPINA3 Polymorphism Is Not Associated With Primary Intracerebral Hemorrhage in a Polish Population
Pera J, et al.
Stroke 2006 Jan

Family History is a Poor Screen for Prothrombotic Genes in Children with Stroke
Johal SC, et al.
J Pediatr 2006 Jan;148(1):68-71

Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth
Flavell DM, et al.
J Mol Med 2006 Jan:1-6

Common Sodium Channel Promoter Haplotype in Asian Subjects Underlies Variability in Cardiac Conduction
Bezzina CR, et al.
Circulation 2006 Jan

 

Diseases of the Respiratory System

Association between interleukin-1 receptor antagonist gene and asthma-related traits in a German adult population
Pattaro C, et al.
Allergy 2006 Feb;61(2):239-44

The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma
Wilson AM, et al.
Allergy 2006 Feb;61(2):254-9

Association of Common Haplotypes of Surfactant Protein A1 and A2 (SFTPA1 and SFTPA2) Genes with Severity of Lung Disease in Cystic Fibrosis
Choi EH, et al.
Pediatr Pulmonol 2006 Jan

Association of IL8, CXCR2 and TNF-alpha polymorphisms and airway disease
Matheson MC, et al.
J Hum Genet 2006 Jan

Lack of an association between a newly identified promoter polymorphism (-1702G > A) of the leukotriene C4 synthase gene and aspirin-intolerant asthma in a Korean population
Choi JH, et al.
Tohoku J Exp Med 2006 Jan;208(1):49-56

Global distribution of a novel trinucleotide microsatellite polymorphism (ATA) in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis
Awomoyi A, et al.
Int J Immunogenet 2006 Feb;33(1):11-5

Polymorphisms of the GSTM1 and GSTT1 genes in patients with allergic diseases in the Czech population
Holla LI, et al.
Allergy 2006 Feb;61(2):265-7

Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma
Holla LI, et al.
Clin Biochem 2006 Jan

The -675 4G/5G plasminogen activator inhibitor-1 promoter polymorphism in house dust mite-sensitive allergic asthma patients
Pampuch A, et al.
Allergy 2006 Feb;61(2):234-8

 

Diseases of the Digestive System

Association of the IL-1RN2 allele with periodontal diseases
Berdeli A, et al.
Clin Biochem 2006 Jan

Polymorphism of HLA-DRB1 gene shows no strong association with ulcerative colitis in Chinese patients
Lu M & Xia B
Int J Immunogenet 2006 Feb;33(1):37-40

Lack of association of MYO9B genetic variants with coeliac disease in a British cohort
Hunt KA, et al.
Gut 2006 Jan

MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists
Meisel P, et al.
Clin Pharmacol Ther 2006 Jan;79(1):62-71

Pharmacokinetics of 6-Thioguanine in Patients With Inflammatory Bowel Disease
Derijks LJ, et al.
Ther Drug Monit 2006 Feb;28(1):45-50

Influence of CYP3A5 Gene Polymorphisms of Donor Rather than Recipient to Tacrolimus Individual Dose Requirement in Liver Transplantation
Yu S, et al.
Transplantation 2006 Jan;81(1):46-51

ERCP findings in idiopathic pancreatitis: patients who are cystic fibrosis gene positive and negative
Alazmi WM, et al.
Gastrointest Endosc 2006 Feb;63(2):234-9

 

Diseases of the Genitourinary System

Association of interferon-{gamma} +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients
Biolo G, et al.
Nephrol Dial Transplant 2006 Jan

Increased frequency of cystic fibrosis transmembrane conductance regulator gene mutations in infertile males
Schulz S, et al.
Fertil Steril 2006 Jan;85(1):135-8

Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Erectile Dysfunction
Erkan E, et al.
J Sex Med 2006 Jan;3(1):69-76

Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection
Gbadegesin RA, et al.
Int J Immunogenet 2006 Feb;33(1):49-53

Functional Polymorphisms in the Vascular Endothelial Growth Factor Gene Are Associated with Development of End-Stage Renal Disease in Males
Doi K, et al.
J Am Soc Nephrol 2006 Jan

 

Complications of Pregnancy, Childbirth, and the Puerperium

Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia
Saarela T, et al.
Eur J Obstet Gynecol Reprod Biol 2006 Jan

Association of a maternal CD14 -159 gene polymorphism with preterm premature rupture of membranes and spontaneous preterm birth in multi-fetal pregnancies
Kalish RB, et al.
J Reprod Immunol 2006 Jan

HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion
Yan WH, et al.
Int J Immunogenet 2006 Feb;33(1):55-8

 

Diseases of the Skin and Subcutaneous Tissue

HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset
Fain PR, et al.
Pigment Cell Res 2006 Feb;19(1):51-7

 

Diseases of the Musculoskeletal System and Connective Tissue

Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility
Lee YH, et al.
Eur J Hum Genet 2006 Jan

Association of Functionally Different RUNX2 P2 Promoter Alleles With BMD
Doecke JD, et al.
J Bone Miner Res 2006 Feb;21(2):265-73

Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients
Chen JY, et al.
Clin Exp Immunol 2006 Feb;143(2):281-7

Polymorphisms in the Aromatase Gene Predict Areal BMD as a Result of Affected Cortical Bone Size: The GOOD Study
Lorentzon M, et al.
J Bone Miner Res 2006 Feb;21(2):332-9

 

Certain Conditions Originating in the Perinatal Period

Genetic investigation of the TSPYL1 gene in sudden infant death syndrome
Hering R, et al.
Genet Med 2006 Jan;8(1):55-8

 

Symptoms, Signs and Ill-defined Conditions

Protective Effects of the Alcohol Dehydrogenase-ADH1B Allele in Children Exposed to Alcohol During Pregnancy
Jacobson SW, et al.
J Pediatr 2006 Jan;148(1):30-7

The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns
Nukui T, et al.
Pharmacogenet Genomics 2006 Feb;16(2):129-38

CYP2C9 polymorphism and warfarin sensitivity in Taiwan Chinese
Chern HD, et al.
Clin Chim Acta 2006 Jan

Heterozygous Mutation in CYP2C19 Significantly Increases the Concentration/Dose Ratio of Racemic Citalopram and Escitalopram (S-citalopram)
Rudberg I, et al.
Ther Drug Monit 2006 Feb;28(1):102-5

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans
Takahashi H, et al.
Pharmacogenet Genomics 2006 Feb;16(2):101-10

 

For more information on HuGE, please visit the HuGENet™ home page

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only.
Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics