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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
April 13, 2006
Volume 16, No. 15

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These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Frequency of thiopurine S-methyltransferase alleles in different ethnic groups living in Spain
Corominas H, et al.
Med Clin (Barc) 2006 Mar;126(11):410-2

Allele and genotype frequencies of polymorphic FMO3 gene in two genetically distinct populations
Hao D, et al.
Cell Biochem Funct 2006 Apr

Distribution of HLA-A, -B allele and haplotype polymorphism in the Tu nationality of Hubei province in China
Qiu X, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):219-21

Polymorphism of vitamin D receptor gene Fok I in Mongolian population of China
Xing S, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):236-7

With genechip technique to investigate HLA-DQB1 gene polymorphisms in south and north regions of China
Wang H, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):238-9

Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China
Wang Q, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):240-1

 

Infectious and Parasitic Diseases

Interleukin-10 promoter polymorphisms are associated with the mode and sequel of HBeAg seroconversion in patients with chronic hepatitis B virus infection
Peng XM, et al.
Liver Int 2006 Apr;26(3):326-33

Association between the Phe206Leu polymorphism of L-selectin and brucellosis
Rafiei A, et al.
J Med Microbiol 2006 May;55(Pt 5):511-6

 

Neoplasms

Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinoma
Lievre A, et al.
Br J Cancer 2006 Mar;94(5):692-7

The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane
Riesco-Eizaguirre G, et al.
Endocr Relat Cancer 2006 Mar;13(1):257-69

Melanocortin Receptor-1 Gene Polymorphisms and the Risk of Cutaneous Melanoma in a Low-Risk Southern European Population
Stratigos AJ, et al.
J Invest Dermatol 2006 Apr

GSTM1 and GSTT1 Polymorphisms, Cigarette Smoking, and Risk of Colon Cancer: A Population-based Case-control Study in North Carolina (United States)
Huang K, et al.
Cancer Causes Control 2006 May;17(4):385-94

Podocalyxin variants and risk of prostate cancer and tumor aggressiveness
Casey G, et al.
Hum Mol Genet 2006 Mar;15(5):735-41

An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer
Bu D, et al.
Breast Cancer Res Treat 2006 Apr

A systematic review of vitamin d receptor gene polymorphisms and prostate cancer risk
Berndt SI, et al.
J Urol 2006 May;175(5):1613-23

A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with risk for melanoma
Okamoto I, et al.
Int J Cancer 2006 Apr

Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors
De Roos AJ, et al.
Neuro-oncol 2006 Apr;8(2):145-55

Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6
Bar-Shira A, et al.
Prostate 2006 Apr

Effect of R264C polymorphism in CYP19A1 gene on BRCA1/2-negative hereditary breast cancer from Shanghai population of China
Song C, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):181-3

Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York
Gaudet MM, et al.
Breast Cancer Res Treat 2006 Apr

 

Endocrine, Nutritional and Metabolic Diseases

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population
Patel S, et al.
Diabetologia 2006 Apr

Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population
Lin WH, et al.
Diabetologia 2006 Apr

HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins
Yang J, et al.
Chin Med J (Engl) 2006 Mar;119(6):458-66

The E23K variant of KCNJ11 encoding the pancreatic {beta}-cell KATP channel subunits Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
Sesti G, et al.
J Clin Endocrinol Metab 2006 Apr

Erythrocyte membrane Na(+),K(+)-ATPase and Mg(2+)-ATPase activities in subjects with methylenetetrahydrofolate reductase (MTHFR) 677 C-->T genotype and moderate hyperhomocysteinaemia. The role of L-phenylalanine and L-alanine
Schulpis KH, et al.
Clin Chem Lab Med 2006;44(4):423-7

The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients
Pettersson-Fernholm K, et al.
Kidney Int 2006 Apr

Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
Ong KL, et al.
Peptides 2006 Apr

 

Mental Disorders

An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects
Kim SJ, et al.
J Neural Transm 2006 Apr

Variation at the DAOA/G30 Locus Influences Susceptibility to Major Mood Episodes but Not Psychosis in Schizophrenia and Bipolar Disorder
Williams NM, et al.
Arch Gen Psychiatry 2006 Apr;63(4):366-73

Effect of team sport participation on genetic predisposition to adolescent smoking progression
Audrain-McGovern J, et al.
Arch Gen Psychiatry 2006 Apr;63(4):433-41

Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder: evidence from 2 birth cohorts
Mill J, et al.
Arch Gen Psychiatry 2006 Apr;63(4):462-9

Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women
Lorenzo A, et al.
Drug Alcohol Depend 2006 Apr

Association study of polymorphisms in glycine transporter with schizophrenia
Tsai SJ, et al.
J Neural Transm 2006 Apr

Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
Kunugi H, et al.
J Neural Transm 2006 Apr

Association between dopamine receptor D1 A-48G polymorphism and methamphetamine abuse
Liu HC, et al.
Psychiatry Clin Neurosci 2006 Apr;60(2):226-31

An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans
Kim SJ, et al.
Neurosci Lett 2006 Mar

Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex
Marenco S, et al.
Am J Psychiatry 2006 Apr;163(4):740-2

RGS4 genotype is not associated with antipsychotic medication response in schizophrenia
Kampman O, et al.
J Neural Transm 2006 Apr

 

Diseases of the Nervous System and Sense Organs

Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease
Kolsch H, et al.
Int J Mol Med 2006 May;17(5):791-4

Perceived Loss of Memory Ability and Cerebral Metabolic Decline in Persons With the Apolipoprotein E-IV Genetic Risk for Alzheimer Disease
Ercoli L, et al.
Arch Gen Psychiatry 2006 Apr;63(4):442-8

Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians
Borenstein AR, et al.
Ethn Dis 2006 Winter;16(1):9-15

A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers
Bullido MJ, et al.
Neurobiol Aging 2006 Apr

alpha-Synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease
Wang CK, et al.
J Neural Transm 2006 Apr

Variants in the RAB3A gene are not associated with mental retardation in the Chinese population
Sun Y, et al.
Neurosci Lett 2006 Mar

Variation at APOE and STH loci and Alzheimer's disease
Zuo L, et al.
Behav Brain Funct 2006 Apr;2(1):13

Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease
Tan EK, et al.
Mov Disord 2006 Apr

Sequence variants of ACE, AGT, AT1R, and PAI-1 as genetic risk factors for vascular dementia
Kim Y, et al.
Neurosci Lett 2006 Apr

 

Diseases of the Circulatory System

The correlation between ICAM-1 gene K469E polymorphism and coronary heart disease
Zhang S, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):205-7

The research on associating the single nucleotide polymorphism of CTLA-4 gene promoter region with idiopathic dilated cardiomyopathy
Liu W, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):198-201

Genetic analysis of CAV1 gene in hypertension and metabolic syndrome
Grilo A, et al.
Thromb Haemost 2006 Apr;95(4):696-701

A linkage between beta-fibrinogen gene -148C/T polymorphism and cerebral infarction
Ma A, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):202-4

Thrombophilic risk factors and homocysteine levels in Behcet's disease in eastern Spain and their association with thrombotic events
Ma Ricart J, et al.
Thromb Haemost 2006 Apr;95(4):618-24

Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study
Wu O, et al.
Health Technol Assess 2006 Apr;10(11):1-110

A study on K469E polymorphism of ICAM1 gene and ICAM1 plasma level in patients with coronary heart disease
Lu F, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):195-7

Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study
Lee CR, et al.
Hum Mol Genet 2006 Apr

 

Diseases of the Respiratory System

beta(2)-Adrenergic receptor polymorphisms: pharmacogenetic response to bronchodilator among African American asthmatics
Tsai HJ, et al.
Hum Genet 2006 Apr

The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma
Gao G, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):169-72

+9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease
Hopkinson NS, et al.
Am J Clin Nutr 2006 Apr;83(4):912-7

Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1
Brogger J, et al.
Eur Respir J 2006 Apr;27(4):682-8

Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
Wjst M, et al.
Respir Res 2006 Apr;7(1):60

Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome
Gong MN, et al.
Eur Respir J 2006 Apr;27(4):674-81

 

Diseases of the Digestive System

Role of CYP2D6 polymorphism in predicting liver fibrosis progression rate in Caucasian patients with chronic hepatitis C
Fishman S, et al.
Liver Int 2006 Apr;26(3):279-84

 

Diseases of the Genitourinary System

A polymorphism of the interleukin 1 receptor antagonist is not associated with polycystic ovary syndrome in Caucasian women
Kolbus A, et al.
Fertil Steril 2006 Feb;85(2):523-5

Analysis of CC chemokine receptor 5 and 2 polymorphisms and renal transplant survival
Yigit B, et al.
Cell Biochem Funct 2006 Apr

Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism
Lin TC, et al.
BMC Med Genet 2006 Apr;7(1):36

Polymorphisms of the peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha genes in Chinese women with polycystic ovary syndrome
Wang Y, et al.
Fertil Steril 2006 Apr

 

Complications of Pregnancy, Childbirth, and the Puerperium

Investigating the correlation between polymorphisms with couple sharing rate of TAP gene and hypertensive disorder complicating pregnancy
Gao M, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):165-8

Association of factor V gene polymorphisms (Leiden; Cambridge; Hong Kong and HR2 haplotype) with recurrent idiopathic pregnancy loss in Tunisia. A case-control study
Zammiti W, et al.
Thromb Haemost 2006 Apr;95(4):612-7

 

Diseases of the Musculoskeletal System and Connective Tissue

Single-nucleotide polymorphisms and haplotypes of bone morphogenetic protein genes and peripheral bone mineral density in young korean men and women
Choi JY, et al.
Calcif Tissue Int 2006 Apr;78(4):203-11

Association of bone metabolism related genes polymorphisms with the effect of raloxifene hydrochloride on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis
Zhang Z, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):129-33

Human ALOX12, but Not ALOX15, Is Associated With BMD in White Men and Women
Ichikawa S, et al.
J Bone Miner Res 2006 Apr;21(4):556-64

The alpha2 type IX collagen tryptophan polymorphism is associated with the severity of disc degeneration in younger patients with herniated nucleus pulposus of the lumbar spine
Higashino K, et al.
Int Orthop 2006 Apr

 

Congenital Anomalies

Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women
Coppede F, et al.
Am J Med Genet A 2006 Apr

Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele
Rendeli C, et al.
Childs Nerv Syst 2006 Apr

 

Certain Conditions Originating in the Perinatal Period

The INS VNTR locus does not associate with Smallness for Gestational Age (SGA), but interacts with SGA to increase insulin resistance in young adults
Vu-Hong TA, et al.
J Clin Endocrinol Metab 2006 Apr

 

Symptoms, Signs and Ill-defined Conditions

Detecting the polymorphism of methylenetetrahydrofolate reductase gene by denaturing high performance liquid chromatography
Li C, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006 Apr;23(2):184-5

Lipoprotein genotype and conserved pathway for exceptional longevity in humans
Atzmon G, et al.
PLoS Biol 2006 Apr;4(4):e113

Apolipoprotein E {epsilon}4 and impaired episodic memory in community-dwelling elderly: a marked gender difference. The Hordaland health study
Lehmann DJ, et al.
J Neurol Neurosurg Psychiatry 2006 Apr

Association of XRCC1 gene polymorphisms with the susceptibility and chromosomal aberration of testicular germ cell tumors
Tsuchiya N, et al.
Int J Oncol 2006 May;28(5):1217-23

 

Injury and Poisoning

Relationship between genetic polymorphism in hMTH1c.83, hOGG1c.326 and hMYHc.335 and risks of chronic benzene poisoning
Zhang ZB, et al.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006 Mar;24(3):134-8

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
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