TABLE 1: Demographic and risk factor characteristics of women with familial epithelial ovarian cancer, nonfamilial epithileal ovarian cancer, and control women from the cancer and steroid hormone study.
Variables |
Familiala (total = 16)
N (%) |
Nonfamilial (total = 455)
N (%) |
(total = 4,025) |
Birth year
< 1930
1930-1939
1940+
Unknown |
4 (25.0)
9 (56.3)
3 (18.8)
0 ( 0.0) |
85 (18.7)
204 (44.8)
166 (36.5)
0 ( 0.0) |
653 (16.2)
1,846 (45.9)
1,526 (37.9)
0 ( 0.0) |
Menopause status
Premenopausal
Perimenopausal
Natural menopause
Surgical menopause
Unknown |
4 (25.0)
2 (12.5)
7 (43.8)
2 (12.5)
1 ( 6.3) |
197 (43.3)
96 (21.1)
91 (20.0)
46 (10.1)
25 ( 5.5) |
1,758 (43.7)
813 (20.2)
628 (15.6)
680 (16.9)
144 ( 3.6) |
Age at menopause
< 40 years
40 - 49.9
50+
Unknown |
3 (25.0)
8 (66.7)
1 ( 8.3)
0 ( 0.0) |
46 (17.8)
145 (56.2)
66 (25.6)
1 (0.4) |
539 (23.8)
1,259 (55.5)
455 (20.1)
14 ( 0.6) |
Total pregnancies
none
1
2-3
>3
Unknown |
0 (0)
2 (12.5)
7 (43.7)
7 (43.7)
0 ( 0.0) |
92 (20.2)
65 (14.3)
190 (41.8)
107 (23.5)
1 ( 0.2) |
397 (9.9)
350 (8.7)
1,623 (40.3)
1,651 (41.0)
4 ( 0.1) |
Anovulatory cycles
none
1 - 24
25 - 49
50+
Unknown |
0 (0)
6 (37.5)
8 (50.0)
2 (12.5)
0 ( 0.0) |
92 (20.2)
177 (38.9)
141 (31.0)
39 ( 8.6)
6 ( 1.3) |
397 ( 9.9)
1,215 (30.2)
1,605 (39.9)
748 (18.6)
60 ( 1.5) |
Education
<=12th grade
13 - 16
>16
Unknown |
8 (50.0)
5 (31.3)
3 (18.8)
0 ( 0.0) |
241 (53.0)
159 (34.9)
55 (12.1)
0 ( 0.0) |
1,900 (47.2)
1,571 (39.0)
550 (13.7)
4 ( 0.1) |
Oral contraceptive use
none
<= 3 mos
> 3 mos
Unknown |
6 (37.5)
2 (12.5)
8 (50.0)
0 ( 0.0) |
221 (48.6)
41 (9.0)
191 (42.0)
2 ( 0.4) |
1,439 (35.8)
240 (6.0)
2,337 (58.1)
9 ( 0.2) |
aFamilial ovarian cancer was defined as cases of ovarian cancer among women with first degree relatives (sisters, mothers, daughters- although there were no affected daughters) reported as having ovarian cancer. Twenty three women with ovarian cancer and 128 without were excluded from this analysis because their family history was unknown.
TABLE 2: Unadjusted odds ratios for ovarian cancer among Jewish women.
Religion |
|
|
|
Jewish |
3 |
15 |
107 |
Non-Jewish |
13 |
440 |
3,913 |
Odds ratio |
8.4
(2.6 - 28.1) |
1.25
(0.72 - 2.1) |
1.0 |
aFamilial ovarian cancer was defined as cases of ovarian cancer among women having a mother, sister, or daughter with ovarian cancer. Five women without ovarian cancer were excluded from this analysis because their religion was unknown, and 23 women with ovarian cancer and 128 without were excluded because their family history was unknown.
TABLE 3: Crude odds ratios for ovarian cancer among Jewish and non-Jewish women with and without a family history of ovarian cancer and the interaction between family history and religion in Jewish women.a
Not Jewish/No family history |
440 |
3,875 |
1.00 |
_ |
Jewish/No family history |
15 |
104 |
1.27 |
0.74 - 2.19 |
Not Jewish/Family history |
13 |
38 |
3.01 |
1.61 - 5.64 |
Jewish/Family history |
3 |
3 |
8.81 |
2.02 - 38.23 |
aFive women without ovarian cancer were excluded from this analysis because their religion was unknown, and 23 women with ovarian cancer and 128 without were excluded because their family history was unknown.
|