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arsenic trioxide
A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | Arsenic (III) Oxide
Arsenic Sesquioxide
Arsenous Acid
Arsenous Acid Anhydride
Arsenous Oxide
White Arsenic | | | | US brand name: | | Trisenox | | | | Abbreviation: | | AS2O3 | | |
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