 |
|
sulindac
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | Sulindac Sulfoxide | | | | US brand names: | | Aflodac
Clinoril | | | | Foreign brand names: | | Algocetil
Apo-Sulin
Arthrocine
Artribid
Citireuma
Clisundac
Imbaral
Novo-Sundac
Reumofil
Reumyl
Sudac
Sulinol
Sulreuma | | | | Abbreviation: | | SULIN | | | | Code name: | | MK-231 | | | | Chemical structure names: | | - (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
- cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
| | |
|
|
