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mechlorethamine hydrochloride The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | | Chloramin Chlorethamine HCl chlorethamine hydrochloride chlorethazine Chlorethazine Hydrochloride Chlormethine Chlormethine Hydrochloride Chloromethine HCl Mechlorethamine mechlorethamine HCl methylchlorethamine Mustard Mustargen HCl Mustargen Hydrochloride Mustine NH-2 N-Lost | | | US brand name: | | Mustargen | | | Foreign brand names: | | Caryolysine Cloramin Erasol Mustine Hydrochloride Onco-Cloramin | | | Abbreviations: | | HN 2 NM | | | Code name: | | WR-147650 | | | Chemical structure names: | | - Bis(2-chloroethyl)methylamine
- ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl
- Methylbis(beta-chloroethyl)amine
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