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plitidepsin A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | | aplidine dehydrodemnin B | | | US brand name: | | Aplidin | | |
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