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monoclonal antibody Lym-1 A murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells. When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081025000402im_/http://www.cancer.gov/images/spacer.gif) | IgG2a murine monoclonal antibody Lym-1 Lym-1 monoclonal antibody Lym-1, IgG2a murine | | ![](https://webarchive.library.unt.edu/eot2008/20081025000402im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081025000402im_/http://www.cancer.gov/images/spacer.gif) | MOAB Lym-1 | | ![](https://webarchive.library.unt.edu/eot2008/20081025000402im_/http://www.cancer.gov/images/spacer.gif) |
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