 |
|
852A
A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | TLR7 agonist 852A
Toll-like receptor agonist 852A | | |
|
|
