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anti-CD137 monoclonal antibody A humanized agonistic monoclonal antibody targeting the CD137 receptor with potential immunostimulatory and antineoplastic activities. Anti-CD137 monoclonal antibody specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. CD137 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family of receptors and is expressed by activated T- and B-lymphocytes and monocytes; its ligand has been found to play an important role in the regulation of immune responses. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20081024142623im_/http://www.cancer.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081024142623im_/http://www.cancer.gov/images/spacer.gif) | anti-4-1BB monoclonal antibody | | ![](https://webarchive.library.unt.edu/eot2008/20081024142623im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081024142623im_/http://www.cancer.gov/images/spacer.gif) | BMS-663513 | | ![](https://webarchive.library.unt.edu/eot2008/20081024142623im_/http://www.cancer.gov/images/spacer.gif) |
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