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recombinant 70-kD heat-shock protein A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081024125211im_/http://www.cancer.gov/images/spacer.gif) | 70-kD Heat-Shock Protein Heat Shock Protein 70 | | ![](https://webarchive.library.unt.edu/eot2008/20081024125211im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081024125211im_/http://www.cancer.gov/images/spacer.gif) | HSP70 | | ![](https://webarchive.library.unt.edu/eot2008/20081024125211im_/http://www.cancer.gov/images/spacer.gif) |
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