ARS | Publication request: Associations of Markers Linked to Major Histocompatibility (MH) Regions With Disease Resistance in Rainbow Trout

Submitted to: Meeting Abstract
Publication Type: Abstract
Publication Acceptance Date: March 30, 2007
Publication Date: May 2, 2007
Citation: Palti, Y., Johnson, N., Rexroad III, C.E., Welch, T.J., Wiens, G.D., Silverstein, J., Vallejo, R.L. Associations of Markers Linked to Major Histocompatibility (MH) Regions With Disease Resistance in Rainbow Trout. Meeting Abstract.

Technical Abstract: The 2005 NCCCWA brood year (75 full-sib families) were challenged with Flavobacterium psychrophilum, the causative agent of bacterial coldwater disease and rainbow trout fry syndrome. Overall mortality rate was 70% with large variation among families. Resistance to the disease was assessed by monitoring post challenge days to death. Phenotypic variation and additive genetic variation were estimated using mixed models of survival analysis. Microsatellite markers were previously isolated from BAC clones that harbor genes of interest and mapped on to the rainbow trout genetic linkage map. The parents and grandparents of the 2005 brood year families were genotyped with markers linked to the four major histocompatibility (MH) genomic regions to assess linkage disequilibrium (LD) between those genomic regions and resistance to the bacterial disease. The impact of MH sequence variation on selective breeding for disease resistance in aquaculture is discussed.