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IGF-1R inhibitor OSI-906 An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGFR-1 stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081025074350im_/http://www.cancer.gov/images/spacer.gif) | OSI-906 | | ![](https://webarchive.library.unt.edu/eot2008/20081025074350im_/http://www.cancer.gov/images/spacer.gif) |
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