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troxacitabine A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name: | | Troxatyl | | | Code names: | | BCH-4556 L-Oddc | | | Chemical structure name: | | 2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)- | | |
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