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therapeutic autologous dendritic cells A population of a type of antigen-presenting cell (APC), the dendritic cell (DC), harvested from a patient and grown in vitro in the presence of tumor-associated antigens (TAAs) derived from the patient's tumor (a technique known as 'pulsing') and then injected back into the patient; autologous DCs so manipulated may stimulate a specific cell-mediated antitumoral cytotoxicity. DCs derived from a patient may also be fused with the patient's tumor cells in vitro to combine sustained tumor antigen expression with the antigen-presenting and immunostimulatory capacities of DCs; when injected back into the patient, these autologous DC-tumor cell hybrids (fusion cells) may stimulate an active antitumoral immune response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081024091704im_/http://www.cancer.gov/images/spacer.gif) | autologous dendritic cells | | ![](https://webarchive.library.unt.edu/eot2008/20081024091704im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081024091704im_/http://www.cancer.gov/images/spacer.gif) | ADC | | ![](https://webarchive.library.unt.edu/eot2008/20081024091704im_/http://www.cancer.gov/images/spacer.gif) |
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