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tamibarotene An orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA.
In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | retinobenzoic acid | | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | Amnoid AMNOLAKE | | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | Am-80 | | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) | 4 [(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid | | ![](https://webarchive.library.unt.edu/eot2008/20081024091408im_/http://www.cancer.gov/images/spacer.gif) |
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