Projects

USING THE GENOME TO UNDERSTAND IMMUNOGENETICS OF POULTRY Appropriated (D)   Accession Number: 412469

GENETIC AND BIOLOGICAL DETERMINANTS OF AVIAN TUMOR VIRUS SUSCEPTIBILITY Appropriated (D)   Accession Number: 411767

GENOMICS AND IMMUNOGENETICS OF NEOPLASTIC DISEASE OF POULTRY Memorandum of Understanding (M)   Accession Number: 408275

EPIDEMIOLOGY, DIAGNOSIS AND CONTROL OF RETROVIRUS INFECTION IN POULTRY Memorandum of Understanding (M)   Accession Number: 408268

GENOME-WIDE SCREEN FOR POLYMORPHIC GENES WITH CISACTING REGULATORY ELEMENTS THAT RESPOND TO MAREK'S DISEASE VIRUS CHALLENGE IN CHICKEN Reimbursable (R)   Accession Number: 412729

GENOME-WIDE SCREEN FOR GENES WITH POLYMORPHIC CIS-ACTING ELEMENTS THAT RESPOND TO MAREK'S DISEASE VIRUS CHALLENGE IN CHICKEN Specific Cooperative Agreement (S)   Accession Number: 412763

Publications

Cross reactive antibody and cytotoxic T lymphocytes from avian influenza H9N2 infected chickens against homologous and heterologous avian influenza isolates - (Abstract) - (28-Jan-09)

Using integrative genomics to elucidate genetic resistance to Marek's disease in chicken - (Book/Chapter)

Cheng, H., Niikura, M., Kim, T., Mao, W., MacLea, K., Hunt, H., Dodgson, J., Burnside, J., Morgan, R., Ouyang, M., Lamont, S., Dekkers, J., Fulton, J., Soller, M., Muir, W. 2008. Using integrative genomics to elucidate genetic resistance to Marek's disease in chicken. In: Pinard M-H, Gay, C., Pastoret, P-P, Dodet, B., editors. Integrative Genomics for Disease Resistance: Animal Genomics for Animal Health. Developments in Biologicals. Basel, Switzerland: Karger. p. 365-372.

Mass spectral data for 64 eluted peptides and structural modeling define peptide binding preferences for class I alleles in two chicken MHC-B haplotypes associated with opposite responses to Marek's disease - (Peer Reviewed Journal)

Sherman, Mark A., Goto, Ronald M., Moore, Roger E., Hunt, Henry D., Lee, Terry D., Miller, Marcia M. 2008. Mass spectral data for 64 eluted peptides and structural modeling define peptide binding preferences for class I alleles in two chicken MHC-B haplotypes associated with opposite responses to Marek's disease. Immunogenetics. 60(9):485-555.

Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference - (Peer Reviewed Journal)

Chen, M., Payne, W.S., Hunt, H.D., Zhang, H., Holmen, S.L., Dodgson, J.B. 2008. Inhibition of Marek's disease virus replication by retroviral vector-based RNA interference. Virology. 377:265-272.

Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs - (Peer Reviewed Journal)

Hunt, Henry D., Fadly, Aly M., Silva, Robert F., Zhang, Huanmin. 2008. Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs. Avian Diseases. 52(3):433-440.

Inhibition of avian tumor viruses by vector-based RNA interference - (Abstract)

Chen, M., Payne, W.S., Hunt, H.D., Zhang, H., Holmen, S.L., Dodgson, J.B. 2008. Inhibition of avian tumor viruses by vector-based RNA interference [abstract]. Plant and Animal Genome Conference. p. 257.

Use of molecularly cloned avian leukosis virus to study antigenic variation following infection of meat-type chickens - (Abstract)

Fadly, A.M., Mays, J.K., Silva, R.F., Hunt, H.D. 2007. Use of molecularly cloned avian leukosis virus to study antigenic variation following infection of meat-type chickens [abstract]. American Association of Avian Pathologists/American Veterinary Medical Association Abstract. p. 37.

Inhibition of avian leukosis virus replication by vector-based RNA interference - (Peer Reviewed Journal)

Chen, M., Granger, A.J., VanBrocklin, M.W., Payne, W.S., Hunt, H.D., Zhang, H.M., Dodgson, J.B., Holmen, S.L. 2007. Inhibition of avian leukosis virus replication by vector-based RNA interference. Virology. 365:464-472.

Marek's Disease Virus Up-Regulates Major Histocompatibility Complex Class II Cell Surface Expression in Infected Cells - (Peer Reviewed Journal)

Niikura, M., Kim, T., Hunt, H.D., Burnside, J., Morgan, R., Dodgson, J., Cheng, H.H. 2007. Marek's disease virus up-regulates major histocompatibility complex class II cell surface expression in infected cells. Virology. 359(1): 212-219.

The Ups and Downs of Mhc Class I Expression and Marek's Disease - (Abstract)

Hunt, H.D. 2006. The ups and downs of MHC class I expression and Marek's disease [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 31.

Molecular Characterization of MD Tumors with Respect to Clonality, Loss of Heterozygosity, and Mdv Integration - (Abstract)

Cheng, H.H., Hunt, H.D., Delany, M.E. 2006. Molecular characterization of MD tumors with respect to clonality, loss of heterozygosity, and MDV integration [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 6.

Characterization of MDV LORF4 and R-LORF10 in MDV-infected cells and chicken - (Abstract)

Kim, T., Hunt, H.D., Cheng, H.H. 2006. Characterization of MDV LORF4 and R-LORF10 in MDV-infected cells and chicken [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 38.

Molecular and biological characterization of a naturally occurring recombinant subgroup B avian leukosis virus (ALV) with a subgroup J like long terminal repeat (LTR) - (Peer Reviewed Journal) - (25-Jul-06)

Marek's Disease Virus Immune Escape Mechanisms - (Proceedings/Symposium)

Hunt, H.D., Kim, T., Niikura, M., Cheng, H.H., Parcells, M., Ewald, S., Osterrieder, K. 2006. Marek's disease virus immune escape mechanisms. American Association of Avian Pathologists. In: American Association of Avian Pathologists Symposium Program. Impact of Subclinical Immunosuppression on Poultry Production, July 2006, Honolulu, Hawaii. p. 61-66.

Using Recombinant Viruses to Query the Functional Significance of the Protein-Protein Interactions Between Chicken Mhc Class II and Marek's Disease Virus Lorf4 and R-Lorf10 - (Abstract)

Cheng, H.H., Kim, T.J., Niikura, M., Hunt, H.D. 2006. Using recombinant viruses to query the functional significance of the protein-protein interactions between chicken MHC class II and Marek's disease virus LORF4 and R-LORF10 [abstract]. International Symposium on Animal Functional Genomics. p. 8.

Isolation and Characterization of An Adventitious Avian Leukosis Virus Isolated from Commercial Marek's Disease Vaccines - (Peer Reviewed Journal)

Fadly, A.M., Silva, R.F., Hunt, H.D., Pandiri, A., Davis, C. 2006. Isolation and characterization of an adventitious avian leukosis virus isolated from commercial Marek's disease vaccines. Avian Diseases. 50:380-385.

Lymphoid Organ Size Varies among Inbred Lines 63, 72 and Their Thirteen Recombinant Congenic Strains of Chickens with the Same Mhc - (Peer Reviewed Journal)

Zhang, H.M., Hunt, H.D., Kulkarni, G.B., Palmquist, D.E., Bacon, L.D. 2006. Lymphoid organ size varies among inbred lines 63, 72 and their thirteen recombinant congenic strains of chickens with the same major histocompatibility complex. Poultry Science. 85:844-853.

At Least One Non-Classical Mhci Molecule in the Chicken Is Alloimmunogenic and Dynamically Expressed on Spleen Cells During Development - (Peer Reviewed Journal)

Hunt, H.D., Goto, R.M., Foster, D.N., Bacon, L.D., Miller, M.M. 2006. At least one YMHCl molecule in the chicken is alloimmunogenic and dynamically expressed on spleen cells during development. Immunogenetics. 58(4):297-307.

Oncornaviruses: Leukosis/sarcoma and Reticuloendotheliosis - (Book/Chapter)

Fadly, A.M., Witter, R.L., Hunt, H.D. 2008. Oncornaviruses: leukosis/sarcomas and reticuloendotheliosis. In: Dufour-Zavala, L., Swayne, D.E., Glisson, J.R., Pearson, J.E., Reed, W.M., Jackwood, M.W., Woolcock, P.R., editors. A Laboratory Manual for the Isolation, Identification and Characterization of Avian Pathogens. 5th edition. Jacksonville, FL: American Association of Avian Pathologists. p. 164-172.

Development and Validation of a Pcr-Rflp Assay to Evaluate Tvb Haplotypes Coding Receptors for Subgroup B and E Avian Leukosis Viruses in White Leghorns - (Peer Reviewed Journal)

Zhang, H.M., Bacon, L.D., Cheng, H.H., Hunt, H.D. 2005. Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathology. 34(4):324-331.

Evaluation of Response of a New Experimental Line of Chickens (Line 0-1) to Avian Leukosis Virus Infection - (Abstract)

Mays, J.K., Hunt, H.D., Pandiri, A., Bacon, L.D., Fadly, A.M. 2005. Evaluation of response of a new experimental line of chickens (line 0-1) to avian leukosis virus infection [abstract]. American Veterinary Medical Association. p. 58.

Integrating Genomic and Immunological Approaches to Understand Marek's Disease - (Abstract)

Cheng, H.H., Niikura, M., Kim, T., MacLea, K.S., Hunt, H.D., Morgan, R., Burnside, J. 2005. Integrating genomic and immunological approaches to understand Marek's disease [abstract]. Keystone Symposia: Systems and Biology (X4), p. 101.

A Marek's Disease Virus Vil-8 Deletion Mutant Has Attenuated Virulence and Confers Protection Against Challenge with a Very Virulent Plus Strain - (Peer Reviewed Journal)

Cui, X., Lee, L.F., Hunt, H.D., Reed, W., Lupiani, B., Reddy, S. 2005. A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain. Avian Diseases. 49(2):199-206.

The Pp38 Gene of Marek's Disease Virus (Mdv) Is Necessary for Cytolytic Infection of B Cells and the Maintenance of the Transformed State But Not for Cytolytic ... Spread of Mdv. - (Peer Reviewed Journal)

Gimeno, I.M., Witter, R.L., Hunt, H.D., Reddy, S.M., Lee, L.F., Silva, R.F. 2005. The pp38 gene of Marek's disease virus (MDV) is necessary for cytolytic infection of B cells and maintenance of the transformed state but not for cytolytic infection of the feather follicle epithelium and horizontal spread of MDV. Journal of Virology. 79(7):4545-4549.

A Genetic Variation Map for Chicken with 2.8 Million Single Nucleotide Polymorphisms - (Peer Reviewed Journal)

Wong, G., Liu, B., Andersson, L., Groenen, M., Hunt, H.D., Cheng, H.H. 2004. A genetic variation map for chicken with 2.8 million single nucleotide polymorphisms. Nature Magazine. 432:717-722.

Identification and Evaluation of Snps at the 3' End of the Tva Gene Segregating among Alsv Resistance and Susceptible Lines of Chickens - (Abstract)

Zhang, H.M., Hunt, H.D., Cheng, H.H., Dodgson, J.B., Romanov, M., Bacon, L.D. 2005. Identification and evaluation of SNPs at the 3' end of the tva gene segregating among ALSV resistance and susceptible lines of chickens [abstract]. Plant & Animal Genome XIII Conference. p. 197:123.

Detection of Subgroup J Avian Leukosis Virus by Using Monoclonal Antibody Against the N Terminus of the Envelope Protein - (Abstract)

Wang, C., Chen, H., Hunt, H.D. 2004. Detection of subgroup J Avian Leukosis virus by using monoclonal antibody against the N terminus of the envelope protein [abstract]. American Veterinary Medical Association. p. 57.

A New Paradigm for the Mechanism of Marek's Disease Vaccination - (Abstract)

Hunt, H.D. 2004. A new paradigm for the mechanism of Marek's disease vaccination [abstract]. International Marek's Disease Symposium Abstracts and Proceedings. Paper No. P. 3.

Identification of Novel Genes Involved in Resistance to Marek's Disease - (Abstract)

Cheng, H.H., Niikura, M., Hunt, H.D. 2004. Identification of novel genes involved in resistance to Marek's disease [abstract]. International Marek's Disease Symposium Abstracts and Proceedings. Paper No. II-5.

Isolation of Subgroup a Avian Leukosis Virus from Commercial Marek's Disease Vaccines - (Abstract)

Fadly, A.M., Silva, R.F., Hunt, H.D. 2004. Isolation of subgroup A avian leukosis virus from commercial Marek's disease vaccines [abstract]. International Marek's Disease Symposium Abstracts and Proceedings. Paper No. P.8.

Identification of Novel Genes Involved in Resistance to Marek's Disease - (Proceedings/Symposium)

Cheng, H.H., Niikura, M., Hunt, H.D. 2004. Identification of novel genes involved in resistance to Marek's disease. International Marek's Disease Symposium Abstracts and Proceedings. Paper II.5.

Identifying Marek's Disease Resistance Gene and Pathways Through Integrative Genomic Approaches - (Proceedings/Symposium)

Cheng, H.H., Niikura, M., Hunt, H.D. 2004. Identifying Marek's disease resistance gene and pathways through integrative genomic approaches. World Veterinary Poultry Association Congress Proceedings, June 8-13, 2004, Istanbul, Turkey. 2004 CD ROM.

Telomerase Activity and Gene Expression in Chicken Embryonic Stem Cells - (Peer Reviewed Journal)

Swanberg, S.E., Payne, W.S., Hunt, H.D., Dodgson, J.B., Delany, M.E. 2004. Telomerase activity and differential expression of telomerase genes and c-myc in chicken cells in vitro. Developmental Dynamics. 231:14-21. Available: www.interscience.wiley.com.

Updated Nomenclature for the Chicken Major Histocompatibility (B and Rfp-Y) Complex - (Peer Reviewed Journal)

Miller, M.M., Bacon, L.D., Hala, K., Hunt, H.D., Ewald, S.J., Kaufman, J., Zoorob, R., Briles, W.E. 2004. 2004 Nomenclature for the chicken major histocompatibility (B and Y) complex. Immunogenetics. 56:261-279. Available: http://springerlink.metapress.com/app/home/journal.asp?

Construction and Characterization of Marek's Disease Viruses (Mdvs) Having Green Fluorescent Protein Expression Tied Directly Or Indirectly to Phosphoprotein 38 (Pp38) Expression - (Peer Reviewed Journal)

Prigge, J.T., Majerciak, V., Hunt, H.D., Dienglewicz, R.L., Parcells, M.S. 2004. Construction and characterization of Marek's disease viruses having green fluorescent protein expression tied directly or indirectly to phosphoprotein 38 expression. Avian Diseases. 48:471-87.

Detection of Exogenous and Endogenous Avian Leukosis Viruses in Commercial Marek's Disease Vaccines - (Proceedings/Symposium)

Fadly, A.M., Silva, R.F., Hunt, H.D. 2003. Detection of exogenous and endogenous avian leukosis viruses in commercial marek's disease vaccines. In: Proceedings of the 170th Annual Meeting of the United States Animal Health Association, October 9-16, 2003, San Diego, California. p. 524-525.

Biocharacteristics Shared by Highly Protective Vaccines Against Marek's Disease - (Peer Reviewed Journal)

Gimeno, I.M., Witter, R.L., Hunt, H.D., Reddy, S.M., Reed, W.M. 2003. Biocharacteristics shared by highly protective vaccines against Marek's disease. Avian Pathology. 33(1):59-68.

Role of the Gene Pp38 in the Pathogenesis of Marek's Disease Virus - (Proceedings/Symposium)

Gimeno, I.M., Hunt, H.D., Witter, R.L., Neumann, U., Reddy, S., Silva, R.F. 2003. Role of the gene pp38 in the pathogenesis of marek's disease virus. World Veterinary Poultry Association Congress Proceedings. p. 101.

A Pcr Based Snp Analysis of the Chicken Tvb Receptor Gene - (Abstract)

Zhang, H.M., Hunt, H.D., Cheng, H.H., Bacon, L.D. 2003. A PCR based SNP analysis of the chicken TVB receptor gene [abstract]. Poultry Science. 82(1):49.

Pathogenicity of Two Recombinant Avian Leukosis Viruses - (Peer Reviewed Journal)

Lupiani, B., Williams, S.M., Silva, R.F., Hunt, H.D., Fadly, A.M. 2003. Pathogenicity of two recombinant avian leukosis viruses. Avian Diseases. 47:425-432.

Lack of Immunodepression in the Antigen Specific Cell Mediated Immune Response after Challenge with Virulent Or Very Virulent Marek's Disease Virus Strains - (Abstract) - (06-Oct-02)

Molecular and Biological Characterization of Naturally Occurring Recombinant Avian Leukosis (Alv) Isolated from Egg-Type Chickens Suffering from Myeloid Leukosis - (Abstract) - (13-Jul-02)

Immunological Features of Serotype 1 Marek's Disease Virus Vaccines - (Abstract)

Gimeno, I.M., Witter, R.L., Hunt, H.D., Reed, W.M. 2002. Immunological features of serotype 1 marek's disease virus vaccines [abstract]. American Veterinary Medical Association. p. 19.