Current Clinical Trials

Standard treatment options:

1. Surgery.
2. Chemoradiation.

Treatment option under clinical evaluation:

• Chemoradiation with subsequent surgery, such as in the RTOG-8501 trial.[1-3]

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II esophageal cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

References

1. Cooper JS, Guo MD, Herskovic A, et al.: Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA 281 (17): 1623-7, 1999.  [PUBMED Abstract]
   
   
2. Herskovic A, Al-Sarraf M: Combination of 5-Fluorouracil and Radiation in Esophageal Cancer. Semin Radiat Oncol 7 (4): 283-290, 1997.  [PUBMED Abstract]
   
   
3. Ajani JA, Komaki R, Putnam JB, et al.: A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction. Cancer 92 (2): 279-86, 2001.  [PUBMED Abstract]
   
   

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