Cellular Classification
More than 90% of bladder carcinomas are transitional cell carcinomas derived
from the uroepithelium. About 6% to 8% are squamous cell carcinomas, and 2%
are adenocarcinomas.[1] Adenocarcinomas may be either of urachal origin or of
nonurachal origin; the latter type is generally thought to arise from
metaplasia of chronically irritated transitional epithelium.[2] Pathologic
grade, which is based on cellular atypia, nuclear abnormalities, and the number
of mitotic figures is of great prognostic importance.
References
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Mostofi FK, Davis CJ, Sesterhenn IA: Pathology of tumors of the urinary tract. In: Skinner DG, Lieskovsky G, eds.: Diagnosis and Management of Genitourinary Cancer. Philadelphia, Pa: WB Saunders, 1988, pp 83-117.
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Wilson TG, Pritchett TR, Lieskovsky G, et al.: Primary adenocarcinoma of bladder. Urology 38 (3): 223-6, 1991.
[PUBMED Abstract]
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