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ACCE Review

Population-based Prenatal Screening for 
Cystic Fibrosis via Carrier Testing

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“Population-based Prenatal Screening for Cystic Fibrosis via Carrier Testing” is a draft document produced by the Foundation for Blood Research (Scarborough, Maine) under a cooperative agreement (UR3/CCU319352) with the CDC, National Office of Public Health Genomics. The ACCE project, named for the four components of evaluation—Analytic validity; Clinical validity; Clinical utility; and Ethical, legal, and social implications —is a model process for evaluating data on emerging genetic tests. The process consists of collecting, evaluating, and interpreting data about DNA-based tests and testing algorithms.

“Population-based Prenatal Screening for Cystic Fibrosis via Carrier Testing” is the first systematic review using the model process, with additional reviews under development.  The purpose of these reviews is to provide a comprehensive compilation of information and is intended for use by individuals and groups involved with shaping policy.  The document is not, in and of itself, intended to recommend policy.

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Population-based Prenatal Screening for Cystic Fibrosis via Carrier Testing

ACCE Review: Population-based Prenatal Screening for Cystic Fibrosis via Carrier Testing
This document is comprised of seven, separate PDF files.  You will need Acrobat Reader This reference links to a non-governmental website to access these files.

blue bullet  Introduction  need free adobe acrobat to access (386 KB)
A description of the model process and overview (Genetic Test Brief)
blue bullet  Disorder/Setting  need free adobe acrobat to access (98 KB)
What is the test aimed at identifying and how will it be used?
blue bullet  Analytic validity  need free adobe acrobat to access (649 KB)
How well does the test perform in the laboratory?
blue bullet  Clinical validity  need free adobe acrobat to access (1740 KB)
How well does the test perform in the clinical setting?
blue bullet  Clinical utility  need free adobe acrobat to access (1031 KB)
How useful is the test?
blue bullet  ELSI  need free adobe acrobat to access (75 KB)
What are the ethical, legal and social implications associated with testing?
blue bullet  Glossary  need free adobe acrobat to access (239 KB)
Terms used in the report

 

This reference links to a non-governmental website
  Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: January 1, 2001 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics
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