Project Number: 1235-51520-037-04
Project Type: Reimbursable

Start Date: Sep 30, 2003
End Date: Aug 31, 2007

Objective:
To determine the role of chromium in glucose and insulin metabolism of human subjects and to determine methods to assess chromium status.

Approach:
We propose to use a double-linked placebo controlled randomized study design with well characterized subjects with type 2 diabetes on diet therapy only. Subjects will be divided into 2 groups and given daily 1000 micrograms of chromium or placebo and the effects on glucose and insulin metabolism and body composition will be determined. Chromium concentrations in urine, plasma, and red blood cells, before, during, and after glucose clamp studies will be evaluated as methods to assess status.