Projects

COUNTERMEASURES TO PREVENT AND CONTROL TUBERCULOSIS IN CATTLE AND WILDLIFE RESERVOIRS Appropriated (D)   Accession Number: 411438

Publications

Humoral Immune Responses of White-tailed Deer (Odocoileus virginianus) to Mycobacterium bovis BCG Vaccination and Experimental Challenge with M. bovis - (Peer Reviewed Journal)

Nol, P., Lyashchenko, K.P., Greenwald, R., Esfandiari, J., Waters, W.R., Palmer, M.V., Nonnecke, B.J., Keefe, T.J., Thacker, T.C., Rhyan, J.C., Aldwell, F.E., Salman, M.D. 2009. Humoral Immune Responses of White-tailed Deer (Odocoileus virginianus) to Mycobacterium bovis BCG Vaccination and Experimental Challenge with M. bovis. Clinical and Vaccine Immunology. 16(3):323-329.

Efficacy and Immunogenicity of Mycobacterium bovis Delta RD1 against Aerosol M. bovis Infection in Neonatal Calves - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Capinos Scherer, C.F., Estes, D.M., Hewinson, R.G., Vordermeier, H.M., Barnes, S.W., Federe, G.C., Walker, J.R., Glynne, R.J., Hsu, T., Weinrick, B., Biermann, K., Larsen, M.H., Jacobs, W.R. 2009. Efficacy and Immunogenicity of Mycobacterium bovis Delta RD1 against Aerosol M. bovis Infection in Neonatal Calves. Vaccine. 27(8):1201-1209.

The Calf Model of Immunity for Development of a Vaccine Against Tuberculosis - (Review Article)

Endsley, J., Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Jacobs, W.R., Larsen, M., Hogg, A., Shell, L., Mcalauy, M., Capinos-Scherer, C., Coffey, T., Howard, C., Villareal-Ramos, B., Estes, M. 2009. The Calf Model of Immunity for Development of a Vaccine Against Tuberculosis. Veterinary Immunology and Immunopathology. 128(1-3):199-204.

Histology, Immunohistochemistry and Ultrastructure of the Bovine Palatine Tonsil with Special Emphasis on Tonsilar Reticular Epithelium - (Peer Reviewed Journal) - (19-Oct-08)

Tuberculosis Diagnosis: Relevancy of Veterinary Applications to Human Disease - (Abstract)

Waters, W.R., Palmer, M.V., Thacker, T.C., Nonnecke, B.J., Lyashchenko, K., Schiller, I., Marg, B., Oesch, B., Vordermeier, M., O'Brien, D., Schmitt, S., Estes, M. 2008. Tuberculosis Diagnosis: Relevancy of Veterinary Applications to Human Disease [abstract].

Serum 25-Hydroxvitamin D Concentrations in Captive and Free-Ranging, White-Tailed Deer (Odocoileus virginianus) - (Peer Reviewed Journal) - (04-Jul-08)

Tuberculosis Diagnosis: Assay Optimization, Validation, and Antigens for Specific Diagnosis - (Abstract)

Waters, W.R., Palmer, M.V., Thacker, T.C., Nonnecke, B.J., Lyashchenko, K., Schiller, I., Marg, B., Oesch, B., Vordermeier, M., O'Brien, D., Schmitt, S., Estes, M. 2008. Tuberculosis Diagnosis: Assay Optimization, Validation, and Antigens for Specific Diagnosis. [abstract].

Vaccination of White-tailed Deer with Mycobacterium bovis Bacillus Calmette Guerin (BCG) - (Proceedings/Symposium)

Thacker, T.C., Palmer, M.V., Waters, W.R. 2007. Vaccination of White-tailed Deer with Mycobacterium bovis Bacillus Calmette Guerin (BCG). In: Proccedings of the 42nd United States-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health, December 5-7, 2007, Tsukuba, Japan.

CAMPYLOBACTER ECOLOGY IN THE TURKEY INTESTINE: SETTING THE STAGE FOR DEVELOPMENT OF PROTECTIVE PROBIOTICS - (Abstract)

Scupham, A.J., Wesley, I.V., Thacker, T.C. 2007. Campylobacter ecology in the turkey intestine: setting the stage for development of protective probiotics [abstract]. 42nd United States - Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p.7.

Vaccination of White-tailed deer (Odocoileus virginianus) with Mycobacterium bovis BCG - (Abstract)

Palmer, M.V., Thacker, T.C., Nol, P., Waters, W.R. 2007. Vaccination of White-tailed deer (Odocoileus virginianus) with Mycobacterium bovis BCG [abstract]. 111th Annual Meeting of the United States Animal Health Association. p. 35.

Improved Specificity for Detection of Mycobacterium bovis in Fresh Tissue Using IS6110 Real-Time PCR - (Abstract)

Thacker, T.C., Harris, B., Palmer, M.V., Waters, W.R. 2007. Improved Specificity for Detection of Mycobacterium bovis in Fresh Tissue Using IS6110 Real-Time PCR [abstract].

Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD Double Deletion Mutant in a Neonatal Calf Aerosol M. bovis Challenge model: Comparisons to Responses Elicited by M. bovis bacille Calmette Guerin - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Scherer, C.F., Estes, D.M., Jacobs, W.R., Glatman-Freedman, A., Larsen, M.H. 2007. Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD Double Deletion Mutant in a Neonatal Calf Aerosol M. bovis Challenge model: Comparisons to Responses Elicited by M. bovis bacille Calmette Guerin. Vaccine. 25(45):7832-7840.

Efficacy of Oral and Parenteral Routes of Mycobacterium bovis bacille Calmette-Guerin Vaccination Against Experimental Bovine Tuberculosis in White-tailed deer (Odocoileus virginianus): A Feasibility Study - (Peer Reviewed Journal)

Nol, P., Palmer, M.V., Waters, W.R., Aldwell, F.E., Buddle, B.M., Triantis, J., Linke, L., Phillips, G., Thacker, T.C., Rhyan, J., Dunbar, M., Salman, M.D. 2008. Efficacy of Oral and Parenteral Routes of Mycobacterium bovis bacille Calmette-Guerin Vaccination Against Experimental Bovine Tuberculosis in White-tailed deer (Odocoileus virginianus): A Feasibility Study. Journal of Wildlife Diseases. 44(2):247-259.

Bovine Tuberculosis: Analyzing the Parameters of the Interferon Gamma Assay and Improved Diagnosis with New Antigens - (Abstract)

Schiller, I., Vordermeier, M., Waters, W.R., Marg-Haufe, B., Palmer, M.V., Thacker, T.C., Hardegger, R., Kyburz, A., Raeber, A., Oesch, B. 2007. Bovine Tuberculosis: Analyzing the Parameters of the Interferon Gamma Assay and Improved Diagnosis with New Antigens [abstract].

Lesion Development and Immunohistochemical Changes in Granulomas from Cattle Experimentally Infected with Mycobacterium bovis - (Peer Reviewed Journal)

Palmer, M.V., Waters, W.R., Thacker, T.C. 2007. Lesion Development and Immunohistochemical Changes in Granulomas from Cattle Experimentally Infected with Mycobacterium bovis. Veterinary Pathology. 44(6):863-874.

Vaccination of White-tailed Deer (Odocoileus virginianus) with Mycobacterium bovis bacillus Calmette Guerin - (Peer Reviewed Journal)

Palmer, M.V., Thacker, T.C., Waters, W.R. 2007. Vaccination of White-tailed Deer (Odocoileus virginianus) with Mycobacterium bovis bacillus Calmette Guerin. Vaccine. 25(36):5489-97.

Associations between Cytokine Gene Expression and Pathology in Cattle infected with Mycobacterium bovis - (Abstract)

Thacker, T.C., Palmer, M.V., Waters, W.R. 2007. Associations between Cytokine Gene Expression and Pathology in Cattle infected with Mycobacterium bovis. [Abstract]. American Association for Microbiology. Abstract No. U-037.

The Neonatal calf Tuberculosis Vaccine Model: Immune Responses to Protective and Non-protective Vaccines after Aerosol Challenge with Virulent Mycobacterium bovis - (Abstract)

Waters, W.R., Palmer, M.V., Nonnecke, B.J., Thacker, T.C., Estes, M., Jacobs, W.R., Larsen, M.L. 2007. The Neonatal calf Tuberculosis Vaccine Model: Immune Responses to Protective and Non-protective Vaccines after Aerosol Challenge with Virulent Mycobacterium bovis [abstract]. The American Association of Immunologists. p. 43.51.

Associations Between Cytokine Gene Expression and Pathology in Mycobacterium bovis Infected Cattle - (Peer Reviewed Journal)

Thacker, T.C., Palmer, M.V., Waters, W.R. 2007. Associations Between Cytokine Gene Expression and Pathology in Mycobacterium bovis Infected Cattle. Veterinary Immunology and Immunopathology. 119(3-4):204-213.

Blood Culture and Stimulation Conditions for the Diagnosis of Tuberculosis in Cervids by the Cervigam Assay - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Thacker, T.C., Orloski, K., Nol, P., Harrington, N.P., Olsen, S.C., Nonnecke, B.J. 2008. Blood Culture and Stimulation Conditions for the Diagnosis of Tuberculosis in Cervids by the Cervigam Assay. Veterinary Record. 162(7):203-208.

INTERPRETATION OF TUBERCULOSIS DIAGNOSTIC TEST RESULTS MAY BE CONFOUNDED IN CATTLE INFECTED WITH MYCOBACTERIUM KANSASII - (Abstract)

Waters, W.R., Palmer, M.V., Thacker, T.C., Harris, N.B., Payeur, J.B., Minion, F.C., Mcnair, J., Pollock, J.M., Lyashchenko, K.P. 2006. Interpretation of tuberculosis diagnostic test results may be confounded in cattle infected with Mycobacterium kansasii [abstract]. Research Workers in Animal Diseases Conference Proceedings. p. 81.

VACCINATION OF WHITE-TAILED DEER WITH MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN (BCG) - (Abstract)

Palmer, M.V., Thacker, T.C., Waters, W.R. 2006. Vaccination of white-tailed deer with mycobacterium bovis bacillus calmette guerin (bcg)[abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 122.

VACINATION OF WHITE-TAILED DEER WITH MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN (BCG) - (Abstract)

Palmer, M.V., Thacker, T.C., Waters, W.R. 2006. Vaccination of white-tailed deer with Mycobacterium bovis bacillus Calmette Guerin (BCG). [abstract]. In: Michigan Bovine Tuberculosis 11th Annual Meeting, June 7-8, 2006, Lansing, Michigan, 2006 CDROM.

ORAL BACILLE CALMETTE-GUERIN (BCG) VACCINATION OF WHITE-TAILED DEER AGAINST BOVINE TUBERCULOSIS - (Abstract)

Nol, P., Palmer, M.V., Waters, W.R., Thacker, T.C., Rhyan, J., Aldwell, F., Buddle, B., Dunbar, M., Salman, M. 2006. Oral bacille Calmette-Guerin (BCG) Vaccination of White-tailed Deer against Bovine Tuberculosis [abstract]. In: Michigan Bovine Tuberculosis 11th Annual Meeting, June 7-8, 2006, Lansing, Michigan, 2006 CDROM.

CORRELATION OF CYTOKINE GENE EXPRESSION WITH PATHOLOGY IN WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) INFECTED WITH MYCOBACTERIUM BOVIS - (Peer Reviewed Journal)

Thacker, T.C., Palmer, M.V., Waters, W.R. 2006. Correlation of Cytokine Gene Expression with Pathology in White-Tailed Deer (Odocoileus virginianus) Infected with Mycobacterium bovis. Clinical and Vaccine Immunology. 13(6):640-647.

EARLY ANTIBODY RESPONSES TO EXPERIMENTAL MYCOBACTERIUM BOVIS INFECTION OF CATTLE - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Thacker, T.C., Bannantine, J.P., Vordermeier, H.M., Hewinson, R.G., Greenwald, R., Esfandiari, J., Mcnair, J., Pollock, J.M. 2006. Early Antibody Responses to Experimental Mycobacterium bovis Infection of Cattle. Clinical and Vaccine Immunology. 13(6):648-654.

IMMUNE RESPONSES TO DEFINED ANTIGENS OF MYCOBACTERIUM BOVIS IN CATTLE EXPERIEMNTALLY INFECTED WITH MYCOBACTERIUM KANSASII - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Thacker, T.C., Payeur, J.B., Harris, N.B., Minion, F.C., Greenwald, R., Esfandiari, J., Andersen, P., Mcnair, J. 2006. Immune Responses to Defined Antigens of Mycobacterium bovis in Cattle Experimentally Infected with Mycobacterium kansasii. Clinical and Vaccine Immunology. 13(6):611-619.

ANTIGEN SPECIFIC PROLIFERATION AND ACTIVATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS FROM MYCOBACTERIUM BOVIS-INFECTED REINDEER - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Thacker, T.C., Minion, F.C., Davis, W.C. 2006. Antigen-specific proliferation and activation of peripheral blood mononuclear cells from Mycobacterium bovis-infected reindeer. Veterinary Immunology and Immunopathology. 111(2006): 263-277.

EFFECT OF DIFFERENT TUBERCULIN SKIN-TESTING REGIMENS ON GAMMA INTERFERON AND ANTIBODY RESPONSES IN CATTLE EXPERIMENTALLY INFECTED WITH MYCOBACTERIUM BOVIS - (Peer Reviewed Journal)

Palmer, M.V., Waters, W.R., Thacker, T.C., Lyashchenko, K. 2006. Effect of Different Tuberculin Skin-Testing Regimens on Gamma Interferon and Antibody Responses in Cattle Experimentally Infected with Mycobacterium bovis. Clinical and Vaccine Immunology. 13(3):387-394.

WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) CYTOKINE EXPRESSION IN RESPONSE TO INFECTION WITH MYCOBACTERIUM BOVIS - (Abstract)

Thacker, T.C., Palmer, M.V., Waters, W.R. 2005. White-tailed deer (odocoileus virginianus) Cytokine Expression in Response to Infection with Mycobacterium Bovis [abstract]. International Conference on Mycobacterium bovis. Paper No. 3085.

MYCOBACTERIUM KANSASII INFECTION OF CATTLE CONFOUNDS INTERPRETATION OF TUBERCULOSIS DIAGNOSTIC TESTS - (Abstract)

Waters, W.R., Palmer, M.V., Thacker, T.C., Payeur, J.B., Minion, F.C., Greenwald, R., Esfandiari, J., Andersen, P., Mcnair, J., Pollock, J.M. 2005. Mycobacterium Kansasii Infection of Cattle Confounds Interpretation of Tuberculosis Diagnostic Tests [abstract]. International Conference on Mycobacterium bovis. p. 26.

EFFECTS OF DIFFERENT SKIN TESTING REGIMENS ON INTERFERON GAMMA AND ANTIBODY RESPONSES IN CATTLE EXPERIMENTALLY INFECTED WITH MYCOBACTERIUM BOVIS - (Abstract)

Palmer, M.V., Waters, W.R., Thacker, T.C., Minion, F.C., Greenwald, R., Esfandiari, J., Andersen, P., Mcnair, J., Pollock, J., Lyashchenko, K. 2005. Effects of Different Skin Testing Regimens on Interferon gamma and Antibody Responses in Cattle Experimentally Infected with Mycobacterium Bovis [abstract]. International Conference on Mycobacterium bovis. p. 24.

EXPERIMENTAL INFECTION OF REINDEER (RANGIFER TARANDUS) WITH MYCOBACTERIUM BOVIS: PATHOLOGICAL AND IMMUNOLOGICAL FINDINGS - (Abstract)

Palmer, M.V., Waters, W.R., Thacker, T.C., Stoffregen, W.C., Slaughter, R.E., Jones, S.L., Pitzer, J.E., Minion, F.C. 2005. Experimental Infection of Reindeer (rangifer tarandus) with Mycobacterium bovis: Pathological and Immunological Findings[abstract]. International Conference on Mycobacterium bovis. p. 70.

LESION DEVELOPMENT AND IMMUNOHISTOCHEMICAL CHANGES IN CATTLE EXPERIMENTALLY INFECTED WITH MYCOBACTERIUM BOVIS - (Abstract)

Palmer, M.V., Waters, W.R., Thacker, T.C., Whipple, D.L. 2005. Lesion Development and Immunohistochemical Changes in Cattle Experimentally Infected with Mycobacterium bovis [abstract]. International Conference on Mycobacterium bovis. p. 70.

EXPERIMENTALLY INDUCED INFECTION OF REINDEER (RANGIFER TARANDUS) WITH MYCOBACTERIUM BOVIS - (Peer Reviewed Journal)

Palmer, M.V., Waters, W.R., Thacker, T.C., Stoffregen, W.C., Thomson, B.V. 2006. Experimentally induced infection of reindeer (Rangifer tarandus) with Mycobacterium bovis. Journal of Veterinary Diagnostic Investigation. 18(2006):52-60.

EFFECTS OF DIFFERENT SKIN TESTING REGIMENS ON INTERFERON GAMMA AND ANTIBODY RESPONSES IN CATTLE EXPERIMENTALLY INFECTED WITH MYCOBACTERIUM BOVIS - (Abstract)

Palmer, M.V., Waters, W.R., Thacker, T.C., Minion, C.F., Greenwald, R., Esfandiari, J., Andersen, P., Mcnair, J., Pollock, J., Lyashchenko, K. 2005. Effects of different skin testing regimens on interferon gamma and antibody responses in cattle experimentally infected with Mycobacterium bovis [abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 7.

ANTIGEN-SPECIFIC PROLIFERATION AND ACTIVATION OF PERIPHERAL BLOOD MONONUCLEAR CELLS FROM MYCOBACTERIUM BOVIS-INFECTED REINDEER - (Proceedings/Symposium)

Waters, W.R., Palmer, M.V., Thacker, T.C., Minion, F.C., Davis, W.C. 2004. Antigen-specific proliferation and activation of peripheral blood mononuclear cells from mycobacterium bovis-infected reindeer. Research Workers in Animal Diseases Conference Proceedings. 85:98.

EXPERIMENTAL INFECTION OF REINDEER (RANGIFER TARNDUS) WITH MYCOBACTERIUM BOVIS; PATHOLOGICAL AND IMMUNOLOGICAL FINDINGS AT: AMERICAN ASSOCIATION OF VETERINARY LABORATORY DIAGNOSTICIANS ANNUAL MEETING. GREENSBORO, NC. - (Abstract)

Palmer, M.V., Waters, W.R., Thacker, T.C., Stoffregen, W.C., Slaughter, W.E., Jones, S.L., Pitzer, J.E., Minion, F.C. 2004. Experimental infection of reindeer (rangifer tarndus) with mycobacterium bovis; pathological and immunological findings [abstract]. American Association of Veterinary Laboratory Diagnosticians. p. 97.

EXPERIMENTAL INFECTION OF REINDEER (RANGIFER TARANDUS)WITH MYCOBACTERIUM BOVIS; PATHOLOGICAL AND IMMUNOLOGICAL FINDINGS - (Abstract)

Palmer, M.V., Waters, W.R., Thacker, T.C., Stoffregen, W.C., Slaughter, R.E., Jones, S.L., Pitzer, J.E., Minion, F.C. 2004. Experimental infection of reindeer (rangifer tarandus)with mycobacterium bovis; pathological and immunological findings [abstract]. Wildlife Disease Association. p.402-403.

WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) CYTOKINE EXPRESSION IN RESPONSE TO INFECTION WITH MYCOBACTERIUM BOVIS - (Proceedings/Symposium)

Thacker, T.C., Palmer, M.V., Waters, W.R. 2004. White-tailed deer (odocoileus virginianus) cytokine expression in response to infection with mycobacterium bovis. Proceedings of Keystone Symposia. p.119.