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 Thursday, May 8, 2008 Volume 20   Number 19
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight
group of senior citizens
May is Stroke Awareness Month
Stroke is the third leading cause of death and a major cause of disability in the United States. Genes play a role in developing risk factors that can lead to a stroke, such as high blood pressure, heart disease, diabetes, and vascular conditions. Read more.
Sections

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blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events

Genomics in The State of CDC: 2007

A Catalog of Published Genome-Wide Association Studies

International HapMap Project non-gov warning icon

Genomics Announcements
 

CDCD sponsored material

CDC's National Office of Public Health Genomics announces a new funding opportunity for genomics translation in education, surveillance, and policy interventions. The deadline for final applications is June 6, 2008.  

   
bullhorn
New report, U.S. System of Oversight of Genetic Testing: A Response to the Charge of the Secretary of Health and Human Services,PDF icon(2.1MB) released by the Secretary’s Advisory Committee on Genetics, Health, and Society in April 2008.
   
bullhorn
Genetic Information Nondiscrimination Act (GINA) approved by the U.S. House of Representatives (414-1) on May 1, 2008. President Bush is expected to sign the Act into law. Read a summary of this Act. non-gov warning icon
   
bullhorn
The Newborn Screening Saves Lives Act of 2007 was signed into law by President Bush April 24, 2008. Read a summary of this Act.


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

FGFR2 gene increases susceptibility to breast
cancer
non-gov warning icon News-Medical.Net, May 6

Variations of the adiponectin gene may predict risk of breast cancer in womennon-gov warning icon News-Medical.Net, May 5

Focusing on genetic mutations and cancer risknon-gov warning icon Medical News Today, May 6

Whole-organ genomic survey depicts journey from normal to malignant cellnon-gov warning icon News-Medical.Net, May 5

Mother, daughter fear genetic link to cancernon-gov warning icon The Miami Herald, May 6

Researchers report the cloning of a key group of human genes, the protein kinasesnon-gov warning icon News-Medical.Net, May 2

New chemicals shield 'genome guardian'non-gov warning icon News-Medical.Net, May 6

Gene effect on colon cancer differs by gendernon-gov warning icon Reuters Health, May 1

BRCA mutations don't spot all high-risk womennon-gov warning icon Washington Post, May 5

Researchers find that a small molecule can activate an important cancer suppressor genenon-gov warning icon NIH News, May 1

line

Diabetes

Erythropoietin gene linked to severe diabetic eye, kidney diseasesnon-gov warning icon News-Medical.Net, May 6

Some diabetics don’t have what they thought they hadnon-gov warning icon New York Times, May 6

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Ethical, Legal, and Social Issues (ELSI)

You 2.0: Closing the genetic gapnon-gov warning icon Portfolio.com, May 7

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Genetic Testing

The mixed blessing of genetic testingnon-gov warning icon CBS News, May 6

Caution urged in choosing gene testsnon-gov warning icon Associated Press, May 5

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Mental Health

Obesity

Pharmacogenetic findings may lead to individualized treatment for schizophrenianon-gov warning icon Medical News Today, May 7

Second genetic link to weight and obesity - new DNA variants found that can help to pile on the poundsnon-gov warning icon Medical News Today, May 6

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Other News

Genomics and biology join forces to fight HIVnon-gov warning icon Swissinfo.ch, May 8

Genes and the environment contribute differently to drinking among young adolescentsnon-gov warning icon News-Medical.Net, May 5

The Montreal Children's Hospital of the MUHC begins search for causes of autismnon-gov warning icon EurekAlert, May 7

Most comprehensive kinome collectionnon-gov warning icon News-Medical.Net, May 5

Suicide victims who were abused have genetic brain differencenon-gov warning icon News-Medical.Net, May 7

Secret to long life in lifestyle not genesnon-gov warning icon News-Medical.Net, May 5

Alcohol and cocaine dependence linked to the Tachykinin receptor 3 genenon-gov warning icon Medical News Today, May 6

Genetic factors identified as increasing risk of osteoporosisnon-gov warning icon Medical News Today, May 2

Lab in a dropnon-gov warning icon EurekAlert, May 6

Phase of clock gene expression in human leukocytes correlates with habitual sleep timingnon-gov warning icon News-Medical.Net, May 1

Redefining disease, genes and allnon-gov warning icon New York Times, May 6

Harmful blood glucose levels linked to genetic mutationnon-gov warning icon News-Medical.Net, May 1

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Genomics in Scientific Literature
Featured Item

On combining family and case-control studies
Pfeiffer RM, et al.
Genet Epidemiol 2008 May

 General Articles

Whole genome-wide association study using affymetrix SNP chip: a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases
Yang HH, et al.
Methods Mol Med 2008;141:23-35

Interactions between genotype and phenotype in bleeding and thrombosis
Franchini M & Mannucci PM
Haematologica 2008 May;93(5):649-52

A HapMap harvest of insights into the genetics of common disease
Manolio TA, et al.
J Clin Invest 2008 May;118(5):1590-605

Asthma genetics: personalizing medicine
Warrier MR & Hershey GK
J Asthma 2008 May;45(4):257-64

Genetics of migraine: an update with special attention to genetic comorbidity
Stam AH, et al.
Curr Opin Neurol 2008 Jun;21(3):288-93

A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part I
de Leon J, et al.
Psychosomatics 2008 May-2008 Jun;49(3):258-70

Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice
Castellani C, et al.
J Cyst Fibros 2008 May

Genetics and genomics of primary biliary cirrhosis
Juran BD & Lazaridis KN
Clin Liver Dis 2008 May;12(2):349-65

Recent advances in the epidemiology of primary biliary cirrhosis
Gross RG & Odin JA
Clin Liver Dis 2008 May;12(2):289-303

Gene-centric Genomewide Association Study via Entropy
Cui Y, et al.
Genetics 2008 May

 
 Family History

Familial aggregation of endometriosis in the Yale Series
Matalliotakis IM, et al.
Arch Gynecol Obstet 2008 May

The validity of the family history screen for assessing family history of mental  disorders
Milne BJ, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Apr

The familial risk of breast cancer in women with endometriosis from Yale series
Matalliotakis IM, et al.
Surg Oncol 2008 May

Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24577 first-degree relatives of 11039 patients with myeloproliferative neoplasms in Sweden
Landgren O, et al.
Blood 2008 May

 

 Genetic Testing

Psychiatrists' Attitudes Regarding Genetic Testing and Patient Safeguards: A Preliminary Study
Hoop JG, et al.
Genet Test 2008 May

Receiving inconclusive genetic test results: An interpretive description of the BRCA1/2 experience
Maheu C & Thorne S
Res Nurs Health 2008 Apr

Familial disease with a risk of sudden death: a longitudinal study of the psychological consequences of predictive testing for long QT syndrome
Hendriks KS, et al.
Heart Rhythm 2008 May;5(5):719-24

 

 Genome-Wide Association Studies

Multiple Genetic Loci for Bone Mineral Density and Fractures
Styrkarsdottir U, et al.
N Engl J Med 2008 Apr

Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
Richards JB, et al.
Lancet 2008 May;371(9623):1505-12

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 7, 2008, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: May 8, 2008 (archived document)
Content Source: National Office of Public Health Genomics