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 Thursday, July 17, 2008 Volume 21   Number 3
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight

newborn sleeping
CDC Celebrates 30 Years of the Newborn Screening Quality Assurance Program
July marks 30 years of CDC’s Newborn Screening Quality Assurance Program, the only comprehensive program in the world devoted to quality assurance of newborn screening tests. Because of this program, thousands of babies are saved from death and disability each year.
Read more.

Sections

 >  View Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events
New DTC genetic policy recommendations adopted by AMA non-gov warning icon
Genetics on Healthfinder.gov

Disease Risk Index, Harvard School of Public Health non-gov warning icon

Genomics Announcements
 

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Save the date! University of Washington to hold Summer Institute on Public Health Genomics June 15 - July 1, 2009. For more information, please contact Leslie Pfeirfer.

   
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The U.S. Senate Special Committee on Aging holds Roundtable on Genetic Testing Oversight on June 12, 2008.
   
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NIH's National Human Genome Research Institute requests proposals for conducting systematic reviews of community–based family health history projects. pdf only (29 KB)
   
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What's New at HuGENet™
July 2008


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

"Smothered" genes combine with mutations to yield poor out come in cancer patients, non-gov warning icon News-Medical.Net, July 15

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ELSI (Ethical, Legal and Social Issues)

Guidelines to prevent genetic discrimination, non-gov warning icon EurekAlert, July 14

Genetic-test firms must follow law, non-gov warning icon MercuryNews.com, July 11

Is genetic testing worth the cost, non-gov warning icon Los Angeles Times, July 14

Danger: Sharing gene data, non-gov warning icon courant.com, July 10

Home genetic tests: How much do you really want to know, non-gov warning icon The Independent, July 12  

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Family History

Alert at family health risk link, non-gov warning icon Heraldsun.com, July 14

U.S. Preventive Medicine: Knowing risk factors & early detection are best strategies for colon cancer prevention, non-gov warning icon U.S. Preventive Medicine, July 14

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Mental Health

Shared gene expression alterations in schizophrenia and bipolar disorder, non-gov warning icon News-Medical.Net, July 17

Variations in the serotonin transporter gene may determine who responds best to antidepressant, non-gov warning icon News-Medical.Net, July 14

Researchers finds further evidence for genetic contribution to autism, non-gov warning icon News-Medical.Net, July 15

Common mechanisms may underlie Autism's seemingly diverse mutations, non-gov warning icon NIH News, July 10

REFILE: New genetic mutation tied to Alzheimer's disease, non-gov warning icon Reuters Health, July 14

 

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Other News

Gene signatures for Scleroderma discovered, non-gov warning icon Science Daily, July 17

Sociological research shows combined impact of genetics, social factors on delinquency, non-gov warning icon EurekAlert, July 14

Genetic resistance to HIV, non-gov warning icon News-Medical.Net, July 17

Susceptibility to pain is affected by premature birth and also genetics, non-gov warning icon News-Medical.Net, July 14

Gene makes Africans more susceptible to HIV, non-gov warning icon COSMOS, July 16

Common genetic variations increase risk of life-long nicotine addiction for young smokers, non-gov warning icon News-Medical.Net, July 13

Survival advantage discovered in mutant testis cells behind genetic disorder, non-gov warning icon News-Medical.Net, July 15

Discover of key patterns in gene packaging, non-gov warning icon News-Medical.Net, July 13

Newborn screening for Pompe disease leads to earlier diagnosis, non-gov warning icon Sleep Review, July 15

Scientists identify 22 genes that control embryonic stem cell fate, non-gov warning icon News-Medical.Net, July 10

New understanding of fetal hemoglobin regulation in patients with sickle cell disease, non-gov warning icon News-Medical.Net, July 15

Advances in RNA research, non-gov warning icon News-Medical.Net, July 10

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Genomics in Scientific Literature
Featured Item

Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank
Yang QH, et al.
Am J Clin Nutr 2008 Jul;88(1):232-46


 General Articles

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms resulting in suboptimal oocyte maturation: a discussion of folate status, neural tube defects, schizophrenia, and vasculopathy
Jongbloet PH, et al.
J Exp Clin Assist Reprod 2008 Jul;5(1):5

Genetic information, obesity, and labor market outcomes
Norton EC & Han E
Health Econ 2008 Jul

A partial least-square approach for modeling gene-gene and gene-environment interactions when multiple markers are genotyped
Wang T, et al.
Genet Epidemiol 2008 Jul

Genetic testing in familial melanoma: uptake and implications
de Snoo FA, et al.
Psychooncology 2008 Jul

Power of Genetic Association Studies in the Presence of Linkage Disequilibrium and Allelic Heterogeneity
Fisher SA & Lewis CM
Hum Hered 2008 Jul;66(4):210-22

Discriminatory Accuracy From Single-Nucleotide Polymorphisms in Models to Predict Breast Cancer Risk
Gail MH
J Natl Cancer Inst 2008 Jul

Prioritisation of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes
Tiffin N, et al.
Physiol Genomics 2008 Jul

The genetics of SLE: an update in the light of genome-wide association studies
Rhodes B & Vyse TJ
Rheumatology (Oxford) 2008 Jul

Impaired performance of FDR-based strategies in whole-genome association studies  when SNPs are excluded prior to the analysis
Marenne G, et al.
Genet Epidemiol 2008 Jul

Bayesian variable and model selection methods for genetic association studies
Fridley BL
Genet Epidemiol 2008 Jul

Host Genetic Factors and Antiviral Immune Responses to Hepatitis C Virus
Thio CL
Clin Liver Dis 2008 Aug;12(3):713-26

New cancer susceptibility loci: Population and familial risks
Hemminki K, et al.
Int J Cancer 2008 Jul

PRESTO: Rapid calculation of order statistic distributions and multiple-testing adjusted P-values via permutation for one and two-stage genetic association studies
Browning BL
BMC Bioinformatics 2008 Jul;9(1):309

Advances in asthma and allergy genetics in 2007
Vercelli D
J Allergy Clin Immunol 2008 Jul

Do We Need Personalized Recommendations for Infants at Risk of Developing Disease?
Hernell O & West C
Nestle Nutr Workshop Ser Pediatr Program 2008;62:239-52

Current and Future Directions in Genomics of Amyotrophic Lateral Sclerosis
Ravits J & Traynor BJ
Phys Med Rehabil Clin N Am 2008 Aug;19(3):461-77

The expanding universe of inflammatory bowel disease genetics
Achkar JP & Duerr R
Curr Opin Gastroenterol 2008 Jul;24(4):429-34


 Family History

For Patients With Colon Cancer, a Family History of Colorectal Cancer is Associated With Reduced Risk of Recurrence and Death
Lang L
Gastroenterology 2008 Jul

Familial psychopathology in the First Episode Psychosis Outcome Study
Morley KI, et al.
Aust N Z J Psychiatry 2008 Jul;42(7):617-26

Risk perception and cancer worries in families at increased risk of familial breast/ovarian cancer
Mellon S, et al.
Psychooncology 2008 Jul

 

 Genetic Testing

Fear of health insurance loss among individuals at risk for Huntington disease
Oster E, et al.
Am J Med Genet A 2008 Jul

Mental health and quality of life after genetic testing for Huntington disease: A long-term effect study in Germany
Licklederer C, et al.
Am J Med Genet A 2008 Jul

Psychosocial issues in genetic testing for familial adenomatous polyposis: a review of the literature
Douma KF, et al.
Psychooncology 2008 Jul

A randomized trial of a breast/ovarian cancer genetic testing decision aid used as a communication aid during genetic counseling
Wakefield CE, et al.
Psychooncology 2008 Jul

Monitoring coping style moderates emotional reactions to genetic testing for hereditary nonpolyposis colorectal cancer: a longitudinal study
Shiloh S, et al.
Psychooncology 2008 Jul

Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk
Wakefield CE, et al.
Cancer 2008 Jul

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending July 16, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

 

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Page last updated: July 17, 2008 (archived document)
Content Source: National Office of Public Health Genomics