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 Thursday, May 17, 2007     Volume 18   Number 20  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
  This weekly update provides information about the impact of human genetic research on disease prevention & public health. open mailbox for email deliveryGet email updates
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National Stroke Month
Stroke is the third leading cause of death and a major cause of disability
in the United States. Read more.

National Mental Health Month
Mental disorders are real, disabling health conditions that have an immense impact on individuals and families in the United States. Read more.
 > View Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotFamily History
blue dotGenetic Testing
blue dotHuGE Articles
blue dotBack Issues


 
Genomics Announcements
   
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The NIH Office of Rare Diseases Publishes First Focus on Rare Diseases Newsletter May 2007 For free download please click here (95.4KB)
Focus on Rare Diseases is the first issue of a quarterly newsletter from the NIH Office of Rare Diseases (ORD).
   
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The Utah Department of Health Chronic Disease Genomics Program has added two new family health history resources to their website.
The first is a Senior-friendly Family Health History Toolkit, and the second is a Health Family Tree Tool that can be downloaded for each family member to use to record health history.



Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
Featured Item

“Specific genes identified that are most likely to become cancer promoters when exposed to DNA promoter hypermethylation” non-gov warning icon
(May 15) News-Medical.Net reports, “Cancer epidemiologists at the University at Buffalo have identified specific genes that are most likely to become cancer promoters when exposed to a process called DNA promoter hypermethylation.”

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“Hyperactivity and academic achievement could be linked by genetics” non-gov warning icon
(May 17) EurekAlert! reports, “Children who are hyperactive tend to do worse academically than their peers who are not hyperactive.”

“Newly identified mechanism for silencing genes points to possible anti-cancer strategies” non-gov warning icon
(May 16) EurekAlert! reports, “Genes provide the instructions used by the individual cells to produce the many different proteins that make up the body.”

“Nutrition and heredity are genetically linked” non-gov warning icon
May 16) EurekAlert! reports, “A challenging goal in biology is to understand how the principal cellular functions are integrated so that cells achieve viability and optimal fitness under a wide range of nutritional conditions.”

“Polyplus-transfection obtains an AFM grant for the development of its gene/drug delivery tool for clinical applications” non-gov warning icon
(May 16) Medical News Today reports, “Polyplus-transfection, a company specializing in research, development and marketing of innovative reagents for drug delivery, gene therapy and transfection, announces today that it has obtained a EUR 80,000 grant from AFM (Association Française contre les Myopathies), France's Muscular Dystrophy Association.”

“Genetic abnormalities associated with esophageal cancer eliminated after treatment with HALO ablation system” non-gov warning icon
(May 15) lifesciencesworld.com reports, “HALO Ablation System cures 96% of patients with dangerous esophagus condition.”

“Loss of gene involved in clot formation may explain bleeding disorder, LAD-III” non-gov warning icon
(May 14) Medical News Today reports, “Patients with the syndrome leukocyte adhesion deficiency (LAD) III suffer from recurrent infections and an increased tendency to bleed.”

“Team unearths genetic risk factors for diabetes” non-gov warning icon
(May 14) Physorg.com reports, “Scientists have discovered three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes, and another that is associated with elevated blood triglycerides.”

“The DNA diet” non-gov warning icon
(May 13) Times Online reports, “New evidence linking obesity to genetics means clinics are now offering tailor-made plans. But are they just another dieting gimmick, asks Sally Brown.”

“Identification of 200 new proteins that interact with the mutated protein that causes Huntington's disease” non-gov warning icon
(May 13) News-Medical.Net reports, “The identification of more than 200 new proteins that interact with the mutated protein that causes Huntington's disease opens the door to developing treatments for the fatal neurodegenerative disorder, said a Baylor College of Medicine researcher who took part in the work that appears online today in the journal Public Library of Science Genetics.”

“Researchers identify human genes targeted by a virus believed to cause Kaposi's sarcoma” non-gov warning icon
(May 13) News-Medical.Net reports, “University of Florida researchers have identified specific human genes targeted by a virus believed to cause Kaposi's sarcoma, a rare form of cancer associated with AIDS and with organ transplants that causes patches of red or purple tissue to grow under people's skin.”

“Genetic risk factors for eating disorders discovered” non-gov warning icon
(May 12) Science Daily reports, “Until recently, it was generally believed that eating disorders such as anorexia nervosa and bulimia nervosa resulted solely from environmental influences such as peer pressure and certain perceived expectations of society.”

“Genetic tests may help improve patients' response to tuberculosis medication” non-gov warning icon
(May 12) Medical News Today reports, “Experts have today highlighted the role that genetics may play in treating the current global tuberculosis (TB) pandemic.”

“Inherited genes linked to toxicity of leukemia therapy” non-gov warning icon
(May 12) Medical News Today reports, “Investigators at St. Jude Children's Research Hospital have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications.”

”Gene advances bring ethical quandaries” non-gov warning icon
(May 11) Boston Globe reports, “A revolution in genetics is leading to almost weekly discoveries about genes linked with diseases such as diabetes, but also creating a dilemma for medical scientists: Should they tell the patients whose DNA was used in the research that they may be at risk for a serious illness?”

“Genetic component to autism” non-gov warning icon
(May 10) News-Medical.Net reports, “Using an innovative statistical approach, a research team from Washington University School of Medicine in St. Louis and the University of California, Los Angeles, has identified two regions of DNA linked to autism.”

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Genomics in Scientific Literature
Featured Item

A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies
Curtis D, et al.
BMC Genet 2007 May;8(1):20

Investigating the phenotypes and genotypes of breast cancer in women with african ancestry: the need for more genetic epidemiology
Hayanga AJ & Newman LA
Surg Clin North Am 2007 Apr;87(2):551-68

Cancer risks for Australian women with a brca1 or a brca2 mutation
Suthers GK
ANZ J Surg 2007 May;77(5):314-9

Disclosure of Genetics Research Results after the Death of the Patient Participant: A Qualitative Study of the Impact on Relatives
Ormondroyd E, et al.
J Genet Couns 2007 May

Parent-child pair design for detecting gene-environment interactions in complex diseases
Tan YD, et al.
Hum Genet 2007 May

Retrospective analysis of haplotype-based case-control studies under a flexible model for gene-environment association
Chen YH, et al.
Biostatistics 2007 May

A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies
Curtis D, et al.
BMC Genet 2007 May;8(1):20

Mutation database for the galactose-1-phosphate uridyltransferase (GALT) gene
Calderon FR, et al.
Hum Mutat 2007 May

Pharmacogenomics of Renin Angiotensin System Inhibitors in Coronary Artery Disease
Tsikouris JP & Peeters MJ
Cardiovasc Drugs Ther 2007 May

Ancillary risk information and pharmacogenetic tests: social and policy implications
Henrikson NB, et al.
Pharmacogenomics J 2007 May

Genetics of human longevity with emphasis on the relevance of HSP70 as candidate genes
Singh R, et al.
Front Biosci 2007;12:4504-13

DNA repair pathways and hereditary cancer susceptibility syndromes
Spry M, et al.
Front Biosci 2007;12:4191-207

SNPs associated with prostate cancer risk and prognosis
Naylor SL
Front Biosci 2007;12:4111-31

Genetics of endometriosis: current status and prospects
Vigano P, et al.
Front Biosci 2007;12:3247-55

Pathogenic mitochondrial DNA mutations in protein-coding genes
Wong LJ
Muscle Nerve 2007 May

Genetic susceptibility for breast cancer: How many more genes to be found?
Oldenburg RA, et al.
Crit Rev Oncol Hematol 2007 May

What do Patients Prefer: Informed Consent Models for Genetic Carrier Testing
Ormond KE, et al.
J Genet Couns 2007 May

Genetics of preterm labour
Orsi NM, et al.
Best Pract Res Clin Obstet Gynaecol 2007 May

Genetic and environmental risk factors for testicular cancer
Richiardi L, et al.
Int J Androl 2007 May

Family History
 In The News

No news articles this week.

 

 In The Scientific Literature

Family history of diabetes and risk of atherosclerotic cardiovascular disease in Korean men and women
Park JW, et al.
Atherosclerosis 2007 May

Genetic Testing
 In The News

No news articles this week.

 

 In The Scientific Literature

Bs19 brca 1 & brca2 gene testing for breast and ovarian cancer in australia and new zealand - the gtg experience
Firgaira F
ANZ J Surg 2007 May;77 Suppl 1:A5

Recommendations from Multi-disciplinary Focus Groups on Cascade Testing and Genetic Counseling for Fragile X-associated Disorders
McConkie-Rosell A, et al.
J Genet Couns 2007 May

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HuGE Published Literature [ back to top ]

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 17, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: May 17, 2007 (archived document)
Content Source: National Office of Public Health Genomics