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 Thursday, January 18, 2007     Volume 18   Number 3  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic research on disease prevention and public health. open mailbox for email deliveryGet email updates
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A CDC-sponsored evidence report on Testing for CYP450 Polymorphisms in Adults With Non-Psychotic Depression Treated With SSRIs has been released by the Agency for Healthcare Research & Quality (AHRQ).

CDC Announcements
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Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: A HuGE review and meta-analysis you will need a free Acrobat reader to view this file(233KB)
(January 2007)

   
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Genomics and Public Health at CDC” This reference links to a non-governmental website
(Jan 17) Red Orbit reports, “Genomics is the study of the entire genome, including all genes and their interactions with each other and with the environment (1).”

"Scientists Debunk So-Called 'Fat Gene'" This reference links to a non-governmental website (last accessed 2/2008)
(Jan 18) abc News reports, “Just as death and taxes are inevitable, some people assume they're also fated to be fat.”

“Fact Sheet: A New Era in Cancer Prevention”
(Jan 17) The White House reports, “Today, The President Visited The National Institutes Of Health (NIH), Toured A Cancer Research Lab, And Participated In A Roundtable Discussion On Advances In The Fight Against Cancer.”

“Scientists Map Gene Regulators” This reference links to a non-governmental website
(Jan 17) Red Orbit reports, “U.S. researchers said Tuesday they have mapped key points in the human genome which may lead to therapies for cancer and other diseases. “

“Bethesda List Center Announces a New Mailing List: Human Genetics Worldwide” This reference links to a non-governmental website
(Jan 17) PR Web reports, “Bethesda List Center, Inc. today introduced a new mailing list; Human Genetics Worldwide.”

“Key finding in rare muscle disease” This reference links to a non-governmental website
(Jan 17) EurekAlert! reports, “The finding is in the current issue of Annals of Neurology, a leading international neurology journal, in work led by Professor Nigel Laing and Dr Kristen Nowak of the Laboratory for Molecular Genetics at the Western Australian Institute for Medical Research (WAIMR) and done in collaboration with a number of European researchers.”

“Researchers find a common genetic risk factor for Parkinson's disease in Asians” This reference links to a non-governmental website
(Jan 16) Mayo Clinic reports, “Researchers at Mayo Clinic in Jacksonville, Fla. and the National Taiwan University Hospital in Taipei, Taiwan have discovered what to date appears to be the most common genetic risk factor for Parkinson's disease worldwide.”

“Macular degeneration has a strong genetic link” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 16) Reuters Health via medicineOnline.com reports, “A new study has fount that a specific form of the apolipoprotein E (APOE) gene, called E2, increases the risk of age-related macular degeneration well beyond the age of 65, whereas another form of APOE called E4, may confer some protection.”

“Nanoparticles yield delivery tools for therapeutic nucleic acids” This reference links to a non-governmental website
(Jan 16) News-Medical.Net reports, “Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.”

“Creating GENETIC MEDICINE”
(Jan 16) The Washington Times reports, “Personalized medicine, the tailored treatments that a few patients now get based on their own DNA, is finally headed for the masses: the many heart patients at risk of deadly blood clots.”

“Early treatment of autism hinges on genetic discoveries” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 16) The Columbus Dispatch reports, “Autism is a complex disorder of social, communicative and behavioral development that usually starts in children before 3 years of age. “

“Midstate briefs: Genetic mutations may cause SIDS”
(Jan 16) Tennessean.com reports, “Sudden infant death syndrome, or SIDS, may be caused by genetic mutations that could lead to fatal arrhythmias, or irregular heart rhythms, in some children, according to two newly published studies involving several Vanderbilt University Medical Center researchers in the online edition of the journal Circulation.”

“shRNAs Targeting Tumor Suppressor Genes” This reference links to a non-governmental website
(Jan 15) Genetic Engineering News reports, “RNAi methodologies have been utilized in small- to large-scale screening projects.”

“Scientists find potential 'off-switch' for HIV virus” This reference links to a non-governmental website
(Jan 12) EurekAlert! reports, “While there is no cure for lingering viral infections such as HIV and herpes, a recent study at Princeton University suggests it may be possible to deactivate such viruses indefinitely with the flick of a genetic switch. “

“Novel regulation of the common tumor suppressor PTEN” This reference links to a non-governmental website
(Jan 12) EurekAlert! reports, “PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes.”

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Genomics in Scientific Literature
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Overview of the pharmacogenomics of cigarette smoking
Ho MK & Tyndale RF
Pharmacogenomics J 2007 Jan

Informative phenotypes for genetic studies of psychiatric disorders
Szatmari P, et al.
Am J Med Genet B Neuropsychiatr Genet 2007 Jan

Gene-environmental interaction in asthma
Yang IA, et al.
Curr Opin Allergy Clin Immunol 2007 Feb;7(1):75-82

Identifying novel genes contributing to asthma pathogenesis
Holloway JW & Koppelman GH
Curr Opin Allergy Clin Immunol 2007 Feb;7(1):69-74

Interleukin-18 genetics and inflammatory disease susceptibility
Thompson SR & Humphries SE
Genes Immun 2007 Jan

Identifying drugs needing pharmacogenetic monitoring in a Korean hospital
Kim YM, et al.
Am J Health Syst Pharm 2007 Jan;64(2):166-75

Polymorphisms of short tandem repeat of genes and breast cancer susceptibility
Zhang W & Yu YY
Eur J Surg Oncol 2007 Jan

Pharmacogenomics and nutrigenomics: synergies and differences
Ghosh D, et al.
Eur J Clin Nutr 2007 Jan

Multiple mutations responsible for frequent genetic diseases in isolated populations
Zlotogora J
Eur J Hum Genet 2007 Jan

DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers
Kotsopoulos J, et al.
Br J Cancer 2007 Jan;96(1):118-25

Cancer risks among BRCA1 and BRCA2 mutation carriers
Levy-Lahad E & Friedman E
Br J Cancer 2007 Jan;96(1):11-5

Genetic etiologies of glaucoma
Wiggs JL
Arch Ophthalmol 2007 Jan;125(1):30-7

Connexin 26 deafness is not always congenital
Orzan E & Murgia A
Int J Pediatr Otorhinolaryngol 2007 Jan

Overview of the pharmacogenomics of cigarette smoking
Ho MK & Tyndale RF
Pharmacogenomics J 2007 Jan

Family History
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“Researchers Discover Genetic Cause For Word-finding Disease” This reference links to a non-governmental website
(Jan 16) Science Daily reports, “Northwestern University researchers have discovered a genetic cause of a mysterious neurological disease in which people have trouble recalling and using words.”

“Masonic lab finds genetic basis for heart attacks” This reference links to a non-governmental website (last accessed 2/2008)
(Jan 16) Uticaod.com reports, “Scientists at the Masonic Medical Research Laboratory have found a new genetic basis for abnormal heart rhythms that can cause sudden cardiac arrest, according to research being made public today.”

“Transplant brother is to be donor”   This reference links to a non-governmental website
(Jan 16) BBC News reports, “The last of four siblings who all have a rare genetic disorder is to have a lifesaving bone marrow transplant - thanks to his brother.”

“New Gene Uncovered For Late-onset Alzheimer's; Findings Replicated In Four Different Ethnic Groups” This reference links to a non-governmental website
(Jan 15) Science Daily reports, “An international team of researchers, led by Columbia University Medical Center, Boston University School of Medicine and the University of Toronto, has uncovered a major new gene – SORL1 – implicated in late-onset Alzheimer’s disease.”

“The Biological Clock is Genetically Determined” This reference links to a non-governmental website
(Jan 12) Softpedia reports, “Do you go to sleep at the same time with the chickens?  Or are you a nigh bird?  Well, researchers have proven it to be hereditary.”

Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring
Wada K, et al.
Prev Med 2006 May;42(5):358-63

Influence of Positive Family History on Clinical Characteristics of Functional Constipation
Chan AO, et al.
Clin Gastroenterol Hepatol 2007 Jan

Familial premature coronary artery disease mortality and obstructive sleep apnea
Gami AS, et al.
Chest 2007 Jan;131(1):118-21

Family history of breast cancer and compliance with mammography in Israel: findings of the National Health Survey 2003-2004 (EUROHIS)
Keinan-Boker L, et al.
Eur J Cancer Prev 2007 Feb;16(1):43-9

Genetic Testing
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“Genetic tests may make Pap smears less vital” This reference links to a non-governmental website
(Jan 17) International Herald Tribune reports, “The big news in the war on cervical cancer is the new vaccine recently approved to prevent the disease.”

“Schanie and her sisters wait, wonder after genetic tests” This reference links to a non-governmental website
(Jan 15) The Courier Journal reports, “Megan Schanie winced as a nurse drew blood containing clues to her genetic destiny.”

“Accuracy Of Gene Expression Test For Heart Transplant Patients Confirmed” This reference links to a non-governmental website
(Jan 14) Medical News Today reports, “For many Americans living with a heart transplant, invasive heart-muscle biopsies that check for organ rejection are a fact of life.”

Familial Effects of BRCA1 Genetic Mutation Testing: Changes in Perceived Family Functioning
Stroup AM & Smith KR
Cancer Epidemiol Biomarkers Prev 2007 Jan;16(1):135-41

BRCA1 genetic testing in 106 breast and ovarian cancer families from southern Italy (Sicily): a mutation analyses
Russo A, et al.
Breast Cancer Res Treat 2007 Jan

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 17, 2007, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System<
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Click here for more information about upcoming events.

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Personalized Medicine & Molecular Diagnostics: Legal, Regulatory and Ethical Perspectives   This reference links to a non-governmental website
March 2, 2007 ~ Tempe, AZ
 

Screening Europe This reference links to a non-governmental website
February 20-21, 2007 ~ Barcelona, Spain

   
 

Genomics Disorders 2007 This reference links to a non-governmental website
March 21-23, 2007 ~ Hinxton, UK

   
New This Week

1st Course in Genetics of Rheumatic and Auto-inflammatory Diseases This reference links to a non-governmental website
April 1-4, 2007 ~ Bertinoro di Romagna, Italy

   
New This Week

Conference On The Medical Genetics With International Participation “Fetus – As A Part Of Family” This reference links to a non-governmental website
May 22-24, 2007 ~ Kharkiv, Ukraine

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Let's Go Surfing
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Public Health Genetics Unit, UK, Newsletter, January 2007 This reference links to a non-governmental website
The Public Health Genetics Unit (PHGU) of the United Kingdom (UK) aims to keep abreast of developments in molecular and clinical genetics, and in their ethical, legal, social and public health implications.

Graphic Gallery from the National Health Museum This reference links to a non-governmental website
Graphics Gallery is a series of labeled diagrams with explanations representing the important processes of biotechnology. Each diagram is followed by a summary of information, providing a context for the process illustrated.

GOLD (Genomes OnLine Database v 2.0) This reference links to a non-governmental website
Genomes Online Database, is a World Wide Web resource for comprehensive access to information regarding complete and ongoing genome projects around the world.
GOLD provides the largest available and most detailed monitoring of genome sequencing projects.


 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: January 18, 2007 (archived document)
Content Source: National Office of Public Health Genomics