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 Thursday, October 12, 2006     Volume 17   Number 15  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
Spotlight
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Primary Immunodeficiency Resource Center This reference links to a non-governmental website
Do you know the early warning signs? You might be able to save a child's life?" Find out about primary immune deficiency genetic disorders.  Check out the Jeffrey Modell Foundation public and provider education campaign.

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CDC Announcements
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New HuGE Review
Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Diseaseyou will need a free Acrobat reader to view this file(213KB)
Casas JP, et al.
Am J Epidemiol 2006 Oct 3
   
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New HuGE Review
Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A Huge-GSEC Review
you will need a free Acrobat reader to view this file(189KB)
Raimondi S, et al.
Am J Epidemiol 2006 Sep 25

   
bullhorn What's New in HuGENet™
October 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Red hair genes up skin cancer risk, study confirms” This reference links to a non-governmental website (last accessed 2/2008)
(Oct 11) Reuters Health via cancerpage.com reports, “Genes involved in skin pigmentation have an effect on a person's skin cancer risk beyond their influence on a person's hair or skin color, a new study shows.”

“Lexicon Genetics Awarded Additional Grant For Study Of Spinal Muscular Atrophy” This reference links to a non-governmental website
(Oct 12) Medical News Today reports, “Lexicon Genetics Incorporated (Nasdaq: LEXG) announced today that its research program to identify targets that may be important in the development of drugs to prevent or treat spinal muscular atrophy (SMA) has been extended for an additional year by the United States Army Medical Research & Materiel Command (USAMRMC).”

“Researchers publish largest genome-wide study of prostate cancer in African American men” This reference links to a non-governmental website
(Oct 11) EurekAlert reports, “Researchers from 14 institutions across the country today announced the results of the first genome-wide linkage study of prostate cancer in African Americans.”

“Children’s Hospital Study Could Help Surgeons Predict Which Transplant Recipients Would Experience Rejection/Tailor Medication” This reference links to a non-governmental website
(Oct 11) Children’s Hospital of Pittsburgh reports, “A Children’s Hospital of Pittsburgh of UPMC transplant surgeon and researcher has received a grant from the National Institutes of Health to study genetic factors that could predispose transplant recipients to rejection.”

“Key Gene Controlling Kidney Development Found” This reference links to a non-governmental website
(Oct 11) Medical News Today reports, “A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital.”

“Glue Ear Probably Due To Faulty Gene” This reference links to a non-governmental website
(Oct 11) Medical News Today reports, “Glue ear, or (adhesive) otitis media, is probably caused by a faulty gene, called called Evi1, say scientists from the Medical Research Council Mammalian Genetics Unit, UK.”

“Genes May Dictate Response to Stress” This reference links to a non-governmental website (last accessed 2/2008)
(Oct 10) HealthDay News via MentalHelp.net reports, “Whether or not you have one or another variant of a particular gene could determine your response to life's ups and downs, a new study finds.”

“Genes, Diet And Heart Disease Linked” This reference links to a non-governmental website
(Oct 10) Medical News reports, “Researchers from the Jean Mayer USDA Human Nutrition Research Center (USDA HNRCA) at Tufts University and colleagues have found another link among genes, heart disease and diet.”

“Key gene controlling kidney development found” This reference links to a non-governmental website
(Oct 10) EurekAlert reports, “St. Jude researchers show that the Six2 gene prevents kidney stem cells from differentiating so they continue to produce specialized cells that help to build the organ.”

“Key to lung cancer chemo resistance revealed” This reference links to a non-governmental website
(Oct 10) EurekAlert reports, “Scientists at Johns Hopkins have discovered how taking the brakes off a "detox" gene causes chemotherapy resistance in a common form of lung cancer.”

“Genetic Association Information Network announces genotyping awards for six common
diseases”
This reference links to a non-governmental website
(Oct 10) EurekAlert reports, “First round of whole Genome Association studies focuses on disorders of the brain, skin and kidney.”

“Genetics to bring about Medical Breakthroughs...” This reference links to a non-governmental website
(Oct 9) Medindia.com reports, “Recently, 10 top Australian researchers have predicted what they hope to be medical breakthroughs of the future.”

“Assessing Groups Of Genetic Variants Improves Prediction Of Type 2 Diabetes” This reference links to a non-governmental website
(Oct 6) Medical News Today reports, “Looking at groups of genetic changes may help to predict who will get type 2 diabetes according to a study led by scientists from the Peninsula Medical School in Exeter.”

“Genes and diet linked to risk factors for heart disease” This reference links to a non-governmental website
(Oct 6) EurekAlert reports, “Researchers from the Jean Mayer USDA Human Nutrition Research Center (USDA HNRCA) at Tufts University and colleagues have found another link among genes, heart disease and diet.”

“A tumor suppressor that promotes cancer cell growth?” This reference links to a non-governmental website
(Oct 6) EurekAlert reports, “Researchers have shown that the tumor suppressor gene H-REV107-1 may actually stimulate tumor progression in some non-small cell lung carcinomas.”

“Research Sheds Light on Rare Genetic Disorder” This reference links to a non-governmental website (last accessed 2/2008)
(Oct 5) MedicineNet.com reports, “Insight into a key protein is helping experts better understand a rare cognitive disorder called Williams-Beuren syndrome.”

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Genomics in Scientific Literature
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Genes, Race, and Population: Avoiding a Collision of Categories
Kahn J
Am J Public Health 2006 Oct

The post-Human Genome Project mindset: race, reliability, and health care
Kimmelman J
Clin Genet 2006 Nov;70(5):427-32

Investments in Cancer Genomics: Who Benefits and Who Decides
Foster MW, et al.
Am J Public Health 2006 Oct

Voluntary Participation and Informed Consent to International Genetic Research
Marshall PA, et al.
Am J Public Health 2006 Oct

Ashkenazi Jews and Breast Cancer: The Consequences of Linking Ethnic Identity to Genetic Disease
Rothman SM, et al.
Am J Public Health 2006 Oct

Public health. Genomics and medicine at a crossroads in Chernobyl
Ginsburg GS, et al.
Science 2006 Oct;314(5796):62-3

Mendelian and complex genetics of susceptibility and resistance to parasitic infections
Campino S, et al.
Semin Immunol 2006 Oct

Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression
Bolufer P, et al.
Leuk Res 2006 Oct

Using DNA pools for genotyping trios
Beckman KB, et al.
Nucleic Acids Res 2006 Oct

CYP450, genetics and Parkinson's disease: gene x environment interactions hold the key
Mellick GD
J Neural Transm Suppl 2006(70):159-65

Family History
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“Early family experience can reverse the effects of genes, UCLA psychologists report” This reference links to a non-governmental website
(Oct 10) EurekAlert reports, “Early family experience can reverse the effect of a genetic variant linked to depression, UCLA researchers report in the current issue of the journal Biological Psychiatry.”

Family history of breast cancer and young age at diagnosis of breast cancer increase risk of second primary malignancies in women: a population-based cohort study
Prochazka M, et al.
Br J Cancer 2006 Oct

Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees
Mondimore FM, et al.
Am J Psychiatry 2006 Sep;163(9):1554-60

Familiality of postpartum depression in unipolar disorder: results of a family study
Forty L, et al.
Am J Psychiatry 2006 Sep;163(9):1549-53

Effects of Acute Tryptophan Depletion on Mood and Facial Emotion Perception Related Brain Activation and Performance in Healthy Women with and without a Family History of Depression
van der Veen FM, et al.
Neuropsychopharmacology 2006 Oct

Heritable susceptibility factors for the development of cancer
Au WW
J Radiat Res (Tokyo) 2006;47 Suppl B:B13-7

Clinical and pathologic features of families with LRRK2-associated Parkinson's disease
Whaley NR, et al.
J Neural Transm Suppl 2006(70):221-9

Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study
Kurz MW, et al.
Mov Disord 2006 Oct

Progress in familial Parkinson's disease
Mizuno Y, et al.
J Neural Transm Suppl 2006(70):191-204

Genetic Testing
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“Molecular Medicine Article Supports the Clinical Utility of Normal Reference Ranges of Gene Expression for Diagnosing and Monitoring Disease” This reference links to a non-governmental website
(Oct 10) Biotech Intelligence reports, “Source MDx today announced the publication of a paper in Molecular Medicine outlining the importance and relevance of establishing a "normal" reference dataset for gene expression assays to distinguish the molecular profile of a disease condition from that of a healthy population.”

“Ceregene Announces Promising Phase 1 Results From Gene Therapy Trial for Parkinson's
Disease”
This reference links to a non-governmental website
(Oct 10) Biotech Intelligence reports, “Ceregene, Inc. announced today that CERE-120, a gene therapy product in development for the treatment of Parkinson's disease, was well tolerated and appeared to reduce symptoms by approximately 40% (p<0.001), as measured by the Unified Parkinson's Disease Rating Scale (UPDRS) motor "off" score, in an open-label Phase 1 study in 12 patients with advanced disease.”

“New Breast Cancer Gene Found” This reference links to a non-governmental website (last accessed 2/2008)
(Oct 9) HealthDay News via livescience.com reports, “Scientists say they've spotted a new breast cancer susceptibility gene that might someday help women ascertain their risk for the disease.”

“McGill researchers find gene that's a leading cause of blindness in newborns” This reference links to a non-governmental website
(Oct 5) Medbroadcast.com reports, “Nearly three years after the devastating news that her baby boy was blind, Nadine Seed is hopeful the veil of darkness could one day be lifted.”

Predictors of uptake of obesity genetic testing among affected adults
Segal ME, et al.
Hum Genet 2006 Sep

Presymptomatic and predictive genetic testing in minors: a systematic review of guidelines and position papers
Borry P, et al.
Clin Genet 2006 Nov;70(5):374-81

Tolerance for uncertainty and perceived risk among women receiving uninformative BRCA1/2 test results
O'neill SC, et al.
Am J Med Genet C Semin Med Genet 2006 Oct

Assessing risk assessment: genetic testing and screening for complex disease
Cox S
Clin Genet 2006 Nov;70(5):438-44

The CF-CIRC study: a French collaborative study to assess the accuracy of Cystic Fibrosis diagnosis in neonatal screening
Sermet-Gaudelus I, et al.
BMC Pediatr 2006 Oct;6(1):25

Attitudes and beliefs of pediatricians and genetic counselors regarding testing and screening for CF and G6PD: Implications for policy
Koopmans J, et al.
Am J Med Genet A 2006 Oct

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending October 11, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Complications of Pregnancy, Childbirth and the Puerperium
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Advisory Committee on Heritable Disorders and Genetic Diseases in Newborns and
Children

December 18-19, 2006 ~ Washington, DC

 

XIV Cochrane Colloquium This reference links to a non-governmental website
October 23-26, 2006 ~ Dublin, Ireland

   
 

Genome-Wide Association Studies: Design and Analysis This reference links to a non-governmental website
October 26-27, 2006 ~ New Haven, CT

   
  HuGENet Short Course This reference links to a non-governmental website (last accessed 2/2008)
November 6-8, 2006 ~ Cambridge, UK
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Let's Go Surfing
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Whole Genome Association Studies
The National Library of Medicine is managing the submission, storage, and access for clinical phenotype measures and associated whole genome genotype data for several different programs.

Harvard Center for Risk Analysis This reference links to a non-governmental website
Using Decision Analysis to Promote Public Health

NIH Aims to Make DNA Sequencing Faster, More Cost Effective
Bethesda (October 4) New Grants Support Sequencing Technologies Development


 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: October 12, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics