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 Thursday, Nov. 30, 2006     Volume 17   Number 21  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genetic discoveries on health care, disease prevention and population health.
Spotlight
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child on swing

Investigating Childhood Leukemia in Churchill County, Nevada  This reference links to a non-governmental website you will need a free Acrobat reader to view this file (732 KB)
Beginning in 2002, the Nevada State Health Division and the Centers for Disease Control and Prevention (CDC) worked together to try to learn why an unexpectedly large number of children in Churchill County had developed leukemia. The investigation did not identify a specific cause but suggested

possible environmental and genetic factors. CDC hopes that this work will help to answer questions about what causes childhood leukemia.

More information from CDC

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CDC Announcements
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New HuGE Review
Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and Endometrial Cancer you will need a free Acrobat reader to view this file(128KB)
Sara H. Olson, et al.
Am J Epidemiol. 2006 Nov 16
   
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Spotlight newsletter launched by University of Washington Center for Genomics and Public Health   This reference links to a non-governmental website you will need a free Acrobat reader to view this file (336 KB)
In November 2006, the University of Washington Center for Genomics and Public Health (UWA CGPH) This reference links to a non-governmental website launched the Spotlight newsletter to educate and update public health practitioners, physicians, and the public on topics in genomics. The first issue of this newsletter highlights the importance of family history in improving public health, and initiatives by the U.S. Surgeon General and CDC’s National Office of Public Health Genomics (NOPHG). The newsletter was disseminated to the 25 branches of the Seattle library system, and medical clinics and their satellite locations throughout Washington.

UWA CGPH and the University of Michigan Center for Public Health and Community Genomics are supported through a cooperative agreement with NOPHG. These Centers provide leadership and technical assistance in genomics, and collaborate on various projects with NOPHG projects (e.g., Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Project and the Family History Public Health Initiative), and state and local health departments.

   
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CDC's 2006 National Health Promotion Conference
View genomics-related presentations from the conference held September 12-14, 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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Featured item

“Gene linked to aggressive 'wet' age-related macular degeneration”   This reference links to a non-governmental website
(Nov 22) EurekAlert! reports, “A gene variant that increases the risk of developing the aggressive "wet" form of age-related macular degeneration (AMD), the most common cause of blindness in people over age 50, is reported in two recent articles in Science by researchers at Yale School of Medicine.”

“Scientists work to identify genes that contribute to early heart attack risk” This reference links to a non-governmental website
(Nov 29) EurekAlert! reports, “Scientists at Wake Forest University Baptist Medical Center and colleagues at four other medical centers have launched a $10 million multi-year study to identify genes that may contribute to early atherosclerosis.”

“Genes, Experiences Determine A Person's Ability To Bounce Back”  This reference links to a non-governmental website
(Nov 29) Medical News Today reports, “Long-term studies of child development indicate that some people remain psychologically healthy despite years of severe deprivation and trauma.”

“Researchers find wrinkles in human genome”  This reference links to a non-governmental website
(Nov 28) physorg.com reports, “A team of international scientists, including researchers at the University of Alberta, have created a map of all the known human genomic variations discovered to this point.”

“World Leaders In Prostate Cancer Genetics Come Together For International Conference 28th - 30th Of November 2006”  This reference links to a non-governmental website
(Nov 28) Medical News Today reports, “This week experts from The Institute of Cancer Research, Europe's leading cancer research centre, will host the second international meeting to discuss the issues around targeted prostate cancer screening in men at increased risk of the disease.”

“Esther Lederberg, Pioneer in Microbial Genetics, Dies at Stanford at 83”  This reference links to a non-governmental website
(Nov 27) Red Orbit reports, “Esther Miriam Zimmer Lederberg, PhD, professor emeritus of microbiology and immunology at the Stanford University School of Medicine, whose more than half-century of studies opened the door for some fundamental discoveries in microbial genetics, died Nov. 11 at Stanford Hospital of pneumonia and congestive heart failure.”

“Master Gene Makes Skeletal Progenitor Cells Differentiate Into Cartilage Cells”  This reference links to a non-governmental website
(Nov 27) Science Daily reports, “Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another, said Baylor College of Medicine researchers in a report that appears online in the journal Proceedings of the National Academy of Sciences.”

“How Gene Patents Are Putting Your Health At Risk”  This reference links to a non-governmental website
(Nov 26) parade.com reports, “A fifth of your genes belong to someone else.”

“Mutated gene link provides hope for migraine sufferers”  This reference links to a non-governmental website
(Nov 26) The Sydney Morning Herald reports, “Breakthrough research by Australian scientists has linked mutated genes, affecting blood vessels and hormones, to migraine headaches.”

“Study Identifies Genes And Mutations Associated With Exercise Traits”  This reference links to a non-governmental website
(Nov 25) Medical News Today reports, “Your parents may be to thank - or to blame - for how your body responds to exercise, and the genes responsible are slowly being identified.”

“Enhanced genome map could help disease research, scientists say”  This reference links to a non-governmental website
(Nov 24) CNN.com reports, “Researchers say they have developed an enhanced map of the human genome that could yield breakthroughs in understanding the genetic origins of illnesses such as heart disease, Alzheimer's and various forms of cancer.”

“Singapore researchers find new mutated gene to increase risk of Parkinson's Disease”  This reference links to a non-governmental website
(Nov 24) People’s Daily Online reports, “Singapore researchers have found an abnormal gene which increases the risk of Parkinson's Disease among the Chinese Singaporeans.”

“Gene Therapy Shows Promise Against Hereditary Lung Disease”  This reference links to a non-governmental website
(Nov 23) Medindia.com reports, “An experimental gene therapy to combat alpha-1 antitrypsin deficiency, a common hereditary disorder that causes lung and liver disease, has caused no harmful effects in patients and shows signs of being effective, University of Florida researchers say.”

“Humans Differ Genetically More Than Previously Thought”  This reference links to a non-governmental website
(Nov 23) Medical News Today reports, “We had thought that 99.9% of our genes are the same, but it seems that the figure is nearer 99.5%, say scientists from the Wellcome Trust Sanger Institute, Cambridge, UK and the Hospital for Sick Children, Toronto, Canada.”

“Multi-Copy DNA More Common Than Thought”  This reference links to a non-governmental website
(Nov 22) Washingtonpost.com reports, “It appears that many more genes than once thought have multiple copies of themselves, called "copy-number variants" -- some of which may contain disease-causing mutations, researchers report.”

“Genetic ‘book of life’ gets a rewrite”  This reference links to a non-governmental website
(Nov 22) MSNBC.com reports, “An international team of scientists unveiled on Wednesday a new human genetic map, or “book of life,” that fills in missing pages and chapters to explain how genes are involved in common diseases.”

“Can we prevent type 1 diabetes by modifying infant nutrition?”  This reference links to a non-governmental website
(Nov 21) EurekAlert! reports, “Within the next 10 years the EU-funded Diabetes Prevention study, part of an international study called TRIGR (Trial to Reduce IDDM in the Genetically at Risk), coordinated at the University of Helsinki, Finland, will generate a definite answer to the question whether early nutritional modification may prevent type 1 diabetes later in childhood.”

“Finding a cure for cancer: the holy grail of science”  This reference links to a non-governmental website
(Nov 21) European Science Foundation reports, “To find a cure for cancer, the modern-day plague of our society – is synonymous to finding the holy grail of science. “

“Nanotechnology continues to advance anticancer gene therapy”  This reference links to a non-governmental website
(Nov 20) News-Medical.Net reports, “Given that cancer is a disease in which genetic errors play a major role, it should come as no surprise that many experts envision a time when gene therapy will play an equally important role in the treatment of cancer.”

“NHGRI funds large-scale sequencing centers”    This reference links to a non-governmental website
(Nov 20) EurekAlert! reports, “The National Human Genome Research Institute (NHGRI) today announced the results of the recent competition for support of its three large-scale sequencing centers, strengthening efforts to use the power of DNA sequencing to unlock the genomic secrets of human diseases.”

“Genetics a Key Factor in Premature Infants’ Devastating Eye Disease”  This reference links to a non-governmental website
(Nov 20) Yale University reports, “Genetics play a major role in predisposing infants to retinopathy of prematurity (ROP), a disease prevalent in premature infants that disrupts normal blood vessel development of the retina and can lead to blindness, researchers at Yale School of Medicine report in the November issue of Pediatrics.”

“Despite Technical Hurdles, Potential to Transform Drug Discovery and Development to Drive Gene Expression Markets”  This reference links to a non-governmental website
(Nov 20) Yahoo reports, “The analysis of gene sequence and gene expression variations allows for the detection of defective genes and polymorphisms associated with specific diseases.”

“Researchers Unravel A Mystery About DNA”  This reference links to a non-governmental website
(Nov 19) Science Daily reports, “UCLA researchers in collaboration with researchers at Rutgers University have solved longstanding mysteries surrounding DNA transcription, the first step in carrying out instructions contained in our genes.”

“Genetics Influence Adolescent Language Problems”  This reference links to a non-governmental website
(Nov 19) Medical News Today reports, “Specific language impairment (SLI) is a condition in which a child's language development is deficient despite showing normal development in all other areas.”

“Gene Silencing Technology Is Quietly Moving Toward The Clinic”  This reference links to a non-governmental website
(Nov 18) Medical News Today reports, “The gene silencing technology showcased in the 2006 Nobel Prize in Physiology or Medicine is on an amazingly fast track toward use in treating a variety of serious diseases, according to an article scheduled for the Nov. 13 issue of the ACS's weekly newsmagazine, Chemical & Engineering News.”

“Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis”  This reference links to a non-governmental website
(Nov 17) EurekAlert! reports, “While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung cancer patients.”

“University Of Iowa Scientists Explore Function Of 'Junk DNA'”  This reference links to a non-governmental website
(Nov 17) Medical News Today reports, “University of Iowa scientists have made a discovery that broadens understanding of a rapidly developing area of biology known as functional genomics and sheds more light on the mysterious, so-called "junk DNA" that makes up the majority of the human genome.”

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Genomics in Scientific Literature
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Simple methods for assessing haplotype-environment interactions in case-only and case-control studies
Kwee LC, et al.
Genet Epidemiol 2006 Nov

Genetic association studies of complex neurological diseases
Abou-Sleiman PM, et al.
J Neurol Neurosurg Psychiatry 2006 Dec;77(12):1302-4

Headliners: Genetic Research: Polymorphisms Modify Breast Cancer Risk in Smokers
Phelps J
Environ Health Perspect 2006 Nov;114(11):A642

Preterm Birth: A Review of Genetic Factors and Future Directions for Genetic Study
Esplin MS
Obstet Gynecol Surv 2006 Dec;61(12):800-6

A Survey of Patients' Experiences with the Cancer Genetic Counseling Process: Recommendations for Cancer Genetics Programs
Kausmeyer DT, et al.
J Genet Couns 2006 Nov

Ethical Issues in Cancer Genetics: 1) Whose Information Is It?
Schneider KA, et al.
J Genet Couns 2006 Nov

Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors
Utecht KN, et al.
Am J Health Syst Pharm 2006 Dec;63(23):2340-8

Sex and Age Specificity of Susceptibility Genes Modulating Survival at Old Age
Passarino G, et al.
Hum Hered 2006 Nov;62(4):213-20

Pharmacogenetics-based coumarin therapy
Gage BF
Hematology Am Soc Hematol Educ Program 2006:467-73

Pharmacogenetics, pharmacogenomics and personalized medicine: are we there yet?
Davies SM
Hematology Am Soc Hematol Educ Program 2006:111-7

Genetic risk factors for inhibitors to factors VIII and IX
Oldenburg J & Pavlova A
Haemophilia 2006 Dec;12 Suppl 6:15-22

Interpretation of simultaneous linkage and family-based association tests in genome screens
Chung RH, et al.
Genet Epidemiol 2006 Nov

Patient Confidentiality vs Disclosure of Inheritable Risk: A Survey-Based Study
Erde EL, et al.
J Am Osteopath Assoc 2006 Oct;106(10):615-20

SNP2NMD: a database of human SNPs (single nucleotide polymorphisms) causing NMD (nonsense-mediated mRNA decay)
Han A, et al.
Bioinformatics 2006 Nov

Pharmacogenetics in the rheumatic diseases
Cronstein BN
Bull Hosp Jt Dis 2006;64(1-2):16-9

HFE mutations and Alzheimer's disease
Connor JR & Lee SY
J Alzheimers Dis 2006 Nov-2006 Dec;10(2-3):267-76

Screening for fragile X syndrome among Brazilian mentally retarded male patients using PCR from buccal cell DNA
Christofolini DM, et al.
Genet Mol Res 2006;5(3):448-53

Pharmacogenomics: challenges and opportunities
Roden DM, et al.
Ann Intern Med 2006 Nov;145(10):749-57

Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: A pharmacogenomic approach
Candore G, et al.
Mech Ageing Dev 2006 Nov

Backward Genotype-Trait Association (BGTA)-Based Dissection of Complex Traits in Case-Control Designs
Zheng T, et al.
Hum Hered 2006 Nov;62(4):196-212

The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes
Kraus VB, et al.
Osteoarthritis Cartilage 2006 Nov

Genetic polymorphism in bladder cancer
Wu X, et al.
Front Biosci 2007;12:192-213

Genetic aspects of preeclampsia
Laivuori H
Front Biosci 2007;12:2372-82

A strategy to search for common obesity and type 2 diabetes genes
Elbers CC, et al.
Trends Endocrinol Metab 2006 Nov

Family History
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“Parental genes do what's best for baby” This reference links to a non-governmental website
(Nov 29) EurekAlert! reports, “A molecular ‘battle of the sexes’ long considered the major driving force in a baby’s development is being challenged by a new genetic theory of parental teamwork.”

“New online tool for family health”  This reference links to a non-governmental website
(Nov 24) The Salt Lake Tribune reports, “The Utah Department of Health has created an online tool to help families discuss and compile data on their health.”

Association between clinical characteristics and risk-reduction interventions in women who underwent BRCA1 and BRCA2 testing: a single-institution study
Uyei A, et al.
Cancer 2006 Nov

Outcome of a structured surveillance programme in women with a familial predisposition for breast cancer
Schmutzler RK, et al.
Eur J Cancer Prev 2006 Dec;15(6):483-9

Acceptance for preventive genetic testing and prophylactic surgery in women with a family history of breast and gynaecological cancers
Ackermann S, et al.
Eur J Cancer Prev 2006 Dec;15(6):474-9

The frequency of a positive family history for colorectal cancer: a population-based study in the Netherlands
de Jong AE & Vasen HF
Neth J Med 2006 Nov;64(10):367-70

Family History, Perceived Risk, and Prostate Cancer Screening among African American Men
Bloom JR, et al.
Cancer Epidemiol Biomarkers Prev 2006 Nov;15(11):2167-73

Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study
Figueiredo JC, et al.
Breast Cancer Res Treat 2006 Nov

Is Family History of Premature Cardiovascular Diseases Appropriate for Detection of Dyslipidemic Children in Population-Based Preventive Medicine Programs? CASPIAN Study
Kelishadi R, et al.
Pediatr Cardiol 2006 Nov

Risk for contralateral breast cancers in a population covered by mammography: effects of family history, age at diagnosis and histology
Ji J & Hemminki K
Breast Cancer Res Treat 2006 Nov

Genetic Testing
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“First Open Genetic Testing Accreditation Workshop Proves A Major Success - Participants From Across Europe Welcome Initiative”  This reference links to a non-governmental website
(Nov 30) Medical News Today reports, “Both the demand for genetic testing and the number of laboratories involved continues to grow in the enlarged EU.”

“First international gene screen for typical ALS is on track”  This reference links to a non-governmental website
(Nov 29) EurekAlert! reports, “The largest-scale search for genes that underlie sporadic amyotrophic lateral sclerosis (ALS), the most common form of the disease, has crossed its first hurdle with the successful compiling of genetic information on more than 1,000 patients and controls.”

“Screening offered to students for Jewish genetic diseases”  This reference links to a non-governmental website (last accessed 2/2008)
(Nov 29) post-gazette.com reports, “Jewish college students of Eastern European descent can receive a free screening for certain genetic conditions Monday at the Hillel Jewish University Center, 4607 Forbes Ave., Oakland.”

“Jefferson Scientists Find Aging Gene Also Protects Against Prostate Cancer Development”  This reference links to a non-governmental website
(Nov 27) Thomas Jefferson University Hospital reports, “Cancer scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have shown that a gene that is involved in regulating aging also blocks prostate cancer cell growth.”

“Microarrays are Go!”  This reference links to a non-governmental website
(Nov 17) Mass High Tech reports, “A workhorse genetic testing tool called a microarray got a lot more respect recently.”

“Gene research may help in bowel cancer fight”  This reference links to a non-governmental website (last accessed 2/2008)
(Nov 17) ABC Online reports, “Researchers from the Hunter Medical Research Institute in New South Wales have identified a gene that may make some people predisposed to developing bowel cancer.”

Perspectives towards predictive testing in Huntington disease
Nagaraja SM, et al.
Neurol India 2006 Oct-2006 Dec;54(4):359-62

Impact of familial adenomatous polyposis on young adults: Attitudes toward genetic testing, support, and information needs
Andrews L, et al.
Genet Med 2006 Nov;8(11):697-703

Impact of hemochromatosis screening in patients with indeterminate results: The hemochromatosis and iron overload screening study
Anderson RT, et al.
Genet Med 2006 Nov;8(11):681-7

Fifteen years of experience in predictive testing for Huntington disease at a single testing center in Victoria, Australia
Trembath MK, et al.
Genet Med 2006 Nov;8(11):673-80

If We Build It ... Will They Come? - Establishing a Cancer Genetics Services Clinic for an Underserved Predominantly Latina Cohort
Ricker C, et al.
J Genet Couns 2006 Nov

The Complexity and Challenges of Genetic Counseling and Testing for Inflammatory Bowel Disease
Cummings SA & Rubin DT
J Genet Couns 2006 Nov

Should every lung cancer patient be tested for EGFR mutation?
Cappuzzo F
Expert Opin Ther Targets 2006 Dec;10(6):789-91

Genotype and phenotype relationship in drug metabolism
Roots I, et al.
Ernst Schering Res Found Workshop 2007(59):81-100

Adding pharmacogenetics information to drug labels: lessons learned
Haga SB, et al.
Pharmacogenet Genomics 2006 Dec;16(12):847-54

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending November 29, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Emory University Predictive Health Symposium 2006   This reference links to a non-governmental website
December 18-19, 2006 ~ Atlanta, GA
New This Week

Genetic Age Symposium: The Era of Personalized Medicine  This reference links to a non-governmental website
December 4, 2006 ~ Chicago, IL

   
 

International Symposium on New Frontiers in Tuberculosis Research
December 4-6, 2006 ~ New Delhi, India

   
New This Week Do These Genes Make Me Look Fat? Genetics, Environment, and Obesity  This reference links to a non-governmental website
December 5, 2006 ~ Washington, DC
   
New This Week Pharmacogenomics  This reference links to a non-governmental website (last accessed 2/2008)
February 1-2, 2007 ~ Bethesda, MD
   
  Screening Europe   This reference links to a non-governmental website
February 20-21, 2007 ~ Barcelona, Spain
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Let's Go Surfing
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“NIH launches 'Health Info Rx Program' on newborn screening and related genetic disorders”  
(Nov 20) NIH News reports, “Physicians can direct patients to consumer-friendly online information with the NIH seal of approval.”

DNA Microarray  This reference links to a non-governmental website
The Genetic Science Learning Center is an outreach education program located in the midst of bioscience research at the University of Utah. Their mission is to help people understand how genetics affects their lives and society. This virtual biotechnique laboratory will walk you through a DNA Microarray experiment.

European Journal of Human Genetics  This reference links to a non-governmental website
The European Journal of Human Genetics is the official Journal of the European Society of Human Genetics, publishing high-quality, original research papers, short reports, News and Commentary articles and reviews in the rapidly expanding field of human genetics and genomics, including a new series on Practical Genetics.

The American Society of Human Genetics  This reference links to a non-governmental website
ASHG serves research scientists, health professionals, and the public by providing forums to share research results at annual meetings This reference links to a non-governmental website and in The American Journal of Human Genetics,  This reference links to a non-governmental website to advance genetic research by advocating for research support, to enhance genetics education by preparing future professionals and informing the public and to promote genetic services and support responsible social and scientific policies.

 

 

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Page last reviewed: November 30, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics