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 Thursday, Nov. 9, 2006     Volume 17   Number 19  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
Spotlight
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Family Health History

Thanksgiving is National Family History Day.  Find out more about the importance of collecting your family's health history. Read more.

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CDC Announcements
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New HuGE Review
Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review you will need a free Acrobat reader to view this file(154KB)
Simon Gilbody, et al.
Am J Epidemiol 2006 Oct 30
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Researchers Develop Novel Method for Treatment of Sickle Cell Disease”  This reference links to a non-governmental website
(Nov 7) VCU News reports, “Virginia Commonwealth University researchers have developed a unique anti-sickling agent that may one day be effective in treating sickle cell disease, a painful and debilitating genetic blood disorder that affects approximately 80,000 Americans.”

“All The Changes In A Bacterium's Complete Set Of Genes Identified During A 44-day Evolution Experiment”  This reference links to a non-governmental website
(Nov 8) Medical News Today reports, “A team led by bioengineering researchers at UC San Diego report in the November issue of Nature Genetics rapid evolutionary changes in a bacterial genome, observed in near-real time over a few days.”

“Gene linked with mental illness shapes brain region, researchers find”  This reference links to a non-governmental website
(Nov 7) EurekAlert! reports, “A gene variant associated with mental illness goes hand-in-hand with enlargement of a brain region that handles negative emotions, researchers at UT Southwestern Medical Center and the Central Texas Veterans Health Care System have found.”

“Rexin-G(TM), The World's First Tumor-Targeted Gene Therapy Vector, Stymies Metastatic Cancer”  This reference links to a non-governmental website
(Nov 7) Medical News Today reports, “Epeius Biotechnologies today announced the publication of clinical data from studies conducted at the University of the Philippines, Asian Hospital and Medical Center, Makati Medical Center, Manila, Philippines and Lutheran Medical Center, New York, USA, revealing the safety and single agent efficacy of Rexin-G(TM) for the treatment of a broad spectrum of chemotherapy-resistant cancers.”

“First HIV gene therapy test encouraging”  This reference links to a non-governmental website
(Nov 6) Muzi.com News reports, “The first test of a potential new gene therapy for HIV -- the virus that causes AIDS -- was encouraging enough for researchers to launch a more extensive trial.”

“Genetic 'missing link' sheds light on sudden cardiac death”  This reference links to a non-governmental website
(Nov 6) EurekAlert! reports, “An electrical imbalance caused by a malfunctioning gene triggers a potentially fatal heart rhythm disorder, according to researchers at Baylor College of Medicine (BCM) and Texas Children's Hospital in Houston.”

“Scientists isolate leukaemia gene”  This reference links to a non-governmental website
(Nov 6) The Age reports, “Scientists have uncovered a powerful, problematic gene that is instrumental in leukaemia, raising hope of a new therapy for the disease.”

“Mutant Gene Causes Severe Kidney Disease In Infants - May Be Reversible, If Diagnosed Early”  This reference links to a non-governmental website
(Nov 6) Medical News Today reports, “Scientists at the University of Michigan Medical School have discovered a previously unknown cause for a severe, early-onset form of kidney disease and renal failure in children: recessive mutations in a gene called phospholipase C epsilon or PLCE1.”

“Scientists Find Problem & Possible Solution In Gene Therapy Delivery”  This reference links to a non-governmental website
(Nov 6) Medical News Today reports, “Scientists at the University of Denver and the University of Colorado believe they are on the trail of a promising solution to a long-standing mechanical roadblock in the delivery of gene therapy.”

“She hopes to help other parents know, understand genetic defect”  This reference links to a non-governmental website (last accessed 2/2008)
(Nov 5) post-gazette.com reports, “It's a genetic disorder that is little understood by those who have not faced it directly, but Tammy Rose wants to help people understand.”

“Analysis Of Breast-Cancer Gene Role Offers Promising Target: Drugs Stop Or Slow Progression Of The Disease”  This reference links to a non-governmental website
(Nov 3) Medical News Today reports, “Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients.”

“Lungs try to repair damaged elastic fibers”  This reference links to a non-governmental website
(Nov 3) EurekAlert reports, “The lungs of patients suffering chronic obstructive pulmonary disease (COPD) attempt to repair damaged elastic fibers, a new finding that contradicts the conventional wisdom on the capabilities of the adult lung.”

“Faulty Gene Doubles Risk of Prostate Cancer”  This reference links to a non-governmental website (last accessed 2/2008)
(Nov 2) CBC News reports, “Men who are missing sections of the CHEK2 kinase gene - which programs production of a chemical that alerts the body to DNA damage - are nearly twice as likely to develop prostate cancer as other men, a new study finds.”

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Genomics in Scientific Literature
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Public willingness to participate in and public opinions about genetic variation research: a review of the literature
Sterling R, et al.
Am J Public Health 2006 Nov;96(11):1971-8

The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development
Wagner K, et al.
Breast Cancer Res Treat 2006 Nov

Review article: interactions between genotype and response to therapy in inflammatory bowel diseases
Herrlinger KR & Jewell DP
Aliment Pharmacol Ther 2006 Nov;24(10):1403-12

Place of genotyping and phenotyping in understanding and potentially modifying outcomes in peritoneal dialysis patients
Axelsson J, et al.
Kidney Int 2006 Nov;70(S103):S138-S145

Genetic susceptibility to retinopathy of prematurity
Bizzarro MJ, et al.
Pediatrics 2006 Nov;118(5):1858-63

A new multimarker test for family-based association studies
Rakovski CS, et al.
Genet Epidemiol 2006 Nov

Genetic association studies: marking them well
Orr N, et al.
J Infect Dis 2006 Dec;194(11):1475-7

Disclosing individual genetic results to research participants
Ravitsky V & Wilfond BS
Am J Bioeth 2006 Nov-2006 Dec;6(6):8-17

Arrhythmia Predisposition Between Rare Disease Paradigms and Common Ion Channel Gene Variants
Schulze-Bahr E
J Am Coll Cardiol 2006 Nov;48(9S):A67-A78

Genes, environment and the value of prospective cohort studies
Manolio TA, et al.
Nat Rev Genet 2006 Oct;7(10):812-20

Genetic Associations in Preterm Birth: A Primer of Marker Selection, Study Design, and Data Analysis
Menon R, et al.
J Soc Gynecol Investig 2006 Nov

Family History
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“Chicago Doctor Helps Families Eradicate Genetic Disease”  This reference links to a non-governmental website
(Nov 4) Medical News Today reports, “In February of 2004, Jennifer and Brian Lester welcomed a healthy baby girl into the world.”

“Gene Therapy A Possibility For Metachromatic Leukodystrophy?”  This reference links to a non-governmental website
(Nov 4) Medical News Today reports, “Metachromatic leukodystrophy (MLD) is an inherited disease that causes progressively more severe neurological defects that result in death early in life.”

“Genetic disposition suspected for human bird flu”  This reference links to a non-governmental website (last accessed 2/2008)
(Nov 2) Reuters Health reports, “Scientists suspect some people have a "genetic disposition" for infection with bird flu, which may explain why some get it and others don't, and why it remains relatively rare, the World Health Organisation said on Thursday.”

Overweight, family history of diabetes and attending schools of lower academic grading are independent predictors for metabolic syndrome in Hong Kong Chinese adolescents
Ozaki R, et al.
Arch Dis Child 2006 Nov

Validation of a Self-Administered, Computerized Tool for Collecting and Displaying the Family History of Cancer
Acheson LS, et al.
J Clin Oncol 2006 Nov

Family history of hypertension is not an independent genetic factor predisposing to ischemic stroke subtypes
Laloux P, et al.
Clin Neurol Neurosurg 2006 Nov

Frequency of major affective disorders in first-degree relatives of patients with type 2 diabetes mellitus
Pravin D, et al.
Indian J Med Res 2006 Sep;124(3):291-8

Ovarian Cancer Screening in Women With a Family History of Breast or Ovarian Cancer
Lacey JV Jr, et al.
Obstet Gynecol 2006 Nov;108(5):1176-84

Phenocopies in BRCA1 and BRCA2 families: Evidence for modifier genes and implications for screening?
Smith A, et al.
J Med Genet 2006 Nov

The role of hereditary nonpolyposis colorectal cancer in the management of familial ovarian cancer
Farrell C, et al.
Genet Med 2006 Oct;8(10):653-7

Genetic Testing
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“Genetic Counseling: What's in it for you?”  This reference links to a non-governmental website
(Nov 8) The Southern Health Magazine reports, “Every month, medical journals seem to be identifying new genetic diseases.”

“World's First CE Marked Real-Time, Gene-Based Test For Improved Detection Of Breast Cancer Launches In Europe”  This reference links to a non-governmental website
(Nov 8) Medical News Today reports, “Veridex, LLC, a Johnson & Johnson company, today announced the availability in Europe of the world's first gene-based diagnostic test designed to detect the spread of breast cancer to the lymph nodes.”

“UIC study evaluates two medications for ADHD”  This reference links to a non-governmental website
(Nov 7) News-Medical.Net reports, “University of Illinois at Chicago researchers are comparing two drugs commonly used to treat attention deficit hyperactivity disorder to determine if genetic factors predict which children will respond to either or both drugs.”

Parental Reactions to Information About Increased Genetic Risk of Type 1 Diabetes Mellitus in Infants
Simonen P, et al.
Arch Pediatr Adolesc Med 2006 Nov;160(11):1131-6

Primary care physicians' attitudes regarding follow-up care for children with positive newborn screening results
Kemper AR, et al.
Pediatrics 2006 Nov;118(5):1836-41

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending November 8, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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The Genome Access Course  This reference links to a non-governmental website (last accessed 2/2008)
November 29-30, 2006 ~ Cold Spring Harbor
  5th International Conference on Bioinformatics & Biotechnology-InCob2006  This reference links to a non-governmental website (last accessed 2/2008)
December 18-20, 2006 ~ New Delhi, India
   
New This Week 34th European Symposium on Calcified Tissues  This reference links to a non-governmental website
May 5-9, 2007 ~ Copenhagen, Denmark
   
  8th International Congress on SLE  This reference links to a non-governmental website
May 23-27, 2007 ~ Shanghai, China
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Let's Go Surfing
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Partnership for Prevention™  This reference links to a non-governmental website
Partnership for Prevention™ is a national membership organization dedicated to building evidence of sound disease prevention and health promotion policies and practices and advocating their adoption by public and private sectors.

African Society of Human Genetics  This reference links to a non-governmental website
The African Society of Human Genetics provides a forum for scientists interested in Human Genetics in Africa to meet, interact, network and collaborate.

Human Genome Collection  This reference links to a non-governmental website
Nature.com presents individual human chromosome sequences accompanied by specially selected paper, articles and letters.


 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: November 9, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics