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 Thursday, May 4, 2006     Volume 16   Number 18  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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collage of images in a circle At A Glance CDC's Office of Genomics and Disease Prevention
Presents an overview of public health genomics at CDC.
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CDC Announcements
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CDC sponsored material New HuGE Review
The epidemiology of medium chain acyl-CoA dehydrogenase deficiency: An update you will need a free Acrobat player to view this file (111KB)
Scott Grosse et al. Genetics in Medicine (April 2006)
   
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What’s New in HuGENet™
May 2006
   
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Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
Apply now. Places are limited.
 
CDC sponsored material
A public health approach to pharmacogenomics and gene-based diagnostics
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Davis R and Khoury MJ.  Pharmacogenomics, April 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“PTSD predisposition might be hereditary” This reference links to a non-governmental website
(May 2) myDNA reports, “A study of identical male twins found that Vietnam combat veterans with post-traumatic stress disorder (PTSD) and their non-combat-exposed identical twins had minor neurologic deficits that veterans without PTSD and their twins did not have.”

“Combination Of Genetic Mutation And Viral Infection May Cause Prostate Cancer”This reference links to a non-governmental website
(May 4) Medical News Today reports, “Significant recent interest in the literature (JAMA 2006;295:1503, Lancet, epub) and by patients has arisen in response to a presentation given by Dr. Eric Klein of the Cleveland Clinic at the 2006 Prostate Cancer Symposium in San Francisco, February 24, 2006. Dr. Klein presented their work on a potential viral etiology for prostate cancer (CaP).”

“Gene Linked to Parkinson's Cripples Mitochondria”This reference links to a non-governmental website
(May 3) Aetna InteliHealth reports, “In a breakthrough that may eventually lead to new ways to treat Parkinson's disease, two independent research groups have found that a gene linked to inherited Parkinson's works by disabling a cell's mitochondria.”

“HIV Pharmacology Workshop: Patch-testing to identify the genetic and clinical characteristics of abacavir hypersensitivity reaction - don’t try this at home”This reference links to a non-governmental website
(May 2) Aidsmap News reports, “Previous research has shown a strong association between a life-threatening abacavir hypersensitivity reaction and the presence of a haplotype, or genetic marker, called HLA-B*5701, that is present in between 5 and 15% of northern Europeans, and which may occur at lower frequencies in other ethnic groups, particularly Africans.”

“Combo treatments eliminate prostate cancer” This reference links to a non-governmental website
(May 2) myDNA reports, “A combination of radiation and suicide gene therapy is eliminating the spread of prostate cancer and providing a long-term vaccine against the disease, according to a study presented at the American Society of Clinical Oncology's annual prostate cancer meeting in San Francisco recently.”

“Genetics blamed for higher instance of breast cancer” This reference links to a non-governmental website (last accessed 2/2008)
(May 2) The Peninsula reports, “The high incidence of breast cancer among younger women in Qatar is a phenomenon which can be attributed to the genetic make-up of the region's female population, a cancer expert told The Peninsula yesterday.”

“Environmentally damaged DNA may contribute to human genetic diversity” This reference links to a non-governmental website
(May 2) News-Medical.Net reports, “In this month's issue of the leading scientific journal Genome Research, scientists from Kyushu University report how environmentally damaged DNA may contribute to human genetic diversity.”

“Research Shows How Visual Stimulation Turns Up Genes to Shape the Brain” This reference links to a non-governmental website
(May 1) Havard Medical School reports, “Scientists have long known that brains need neural activity to mature and that sensory input is most important during a specific window of time called the "critical period" when the brain is primed for aggressive learning. Vision, hearing and touch all develop during such critical periods, while other senses, such as the olfactory system, maintain lifelong plasticity.”

“Testing for Jewish genetic diseases urged”
(May 1) Frederick News-Post Online reports, “Geneticist Dr. Adele Schneider wants to help parents prevent tragedy.”

“Kiwi genetics software a top Apple download” This reference links to a non-governmental website (last accessed 2/2008)
(May 1) The Dominion Post reports, “User-friendly genetics software developed in Auckland has become the most popular science download from Apple Computer's website worldwide.”

“DNA Taxi” This reference links to a non-governmental website
(May 1) News-Medical.Net reports, “Despite few successes to date, gene therapy is a highly promising approach for medical therapy in the future.”

“Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart
rhythm”
This reference links to a non-governmental website
(May 1) EurekAlert! reports, “Using a new genomic strategy that has the power to survey the entire human genome and identify genes with common variants that contribute to complex diseases, researchers at Johns Hopkins, together with scientists from Munich, Germany, and the Framingham Heart Study, U.S.A., have identified a gene that may predispose some people to abnormal heart rhythms that lead to sudden cardiac death, a condition affecting more than 300 thousand Americans each year.”

“Clinical Utility Of Two Novel Genes That Can Identify Patients At Higher Risk For Early Breast Cancer Recurrence” This reference links to a non-governmental website
(April 30) Medical News Today reports, “AviaraDx, Inc., formerly known as Arcturus Bioscience, Inc., a leader in molecular cancer profiling, announced today that a study, conducted in collaboration with Mayo Clinic, demonstrated the clinical utility of two novel genes that can identify patients at higher risk for early breast cancer recurrence and has been published in the April 2006 issue of Clinical Cancer Research.”

“Genetics Researcher Wins $500,000 Award” This reference links to a non-governmental website
(April 29) CBS News reports, “A biologist whose pioneering research in genetics led to the exploration of diseases like Alzheimer's and Parkinson's has been awarded the nation's richest prize in medicine and biomedical research.”

“Feinstein researchers identify intelligence gene” This reference links to a non-governmental website
(April 27) EurekAlert! reports, “Psychiatric researchers at The Zucker Hillside Hospital campus of The Feinstein Institute for Medical Research have uncovered evidence of a gene that appears to influence intelligence.”

“Gene linked to Lou Gehrig's disease” This reference links to a non-governmental website
(April 27) myDNA reports, “Two teams of researchers at Northwestern University have found a novel pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), aka Lou Gehrig's disease, at the molecular level.”

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Genomics in Scientific Literature
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Assessment and Communication of Lifetime Disease Risk by Genetic Counselors: Maintaining the Link between Research and Practice
Chase GA
Hum Hered 2006 Apr;61(2):65-6

Direct detection of null alleles in SNP genotyping data
Carlson CS, et al.
Hum Mol Genet 2006 Apr

Hereditary cancer predisposition in children: Genetic basis and clinical implications
Strahm B & Malkin D
Int J Cancer 2006 Apr

Family history of breast cancer and short-term effects of childbirths on breast cancer risk
Albrektsen G, et al.
Int J Cancer 2006 Apr

Coverage and power in genomewide association studies
Jorgenson E & Witte JS
Am J Hum Genet 2006 May;78(5):884-8

Efficient study designs for test of genetic association using sibship data and unrelated cases and controls
Li M, et al.
Am J Hum Genet 2006 May;78(5):778-92

Cytokine gene polymorphism in human disease: on-line databases, Supplement 3
Hollegaard MV & Bidwell JL
Genes Immun 2006 Apr

Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database
Lin BK, et al.
Am J Epidemiol 2006 Apr

Genetic determinants of carotid ultrasound traits
Pollex RL & Hegele R
Curr Atheroscler Rep 2006 May;8(3):206-15

Genetic susceptibility to thrombosis
Luyendyk JP, et al.
Curr Atheroscler Rep 2006 May;8(3):193-7

Nonconventional genetic risk factors for cardiovascular disease
Tymchuk CN, et al.
Curr Atheroscler Rep 2006 May;8(3):184-92

Genetic markers of oxidative stress and coronary atherosclerosis
Madamanchi NR, et al.
Curr Atheroscler Rep 2006 May;8(3):177-83

Pharmacogenetics of antipsychotic therapy: pivotal research issues and the prospects for clinical implementation
Lerer B & Segman RH
Dialogues Clin Neurosci 2006;8(1):85-94

Clinical impact of recently detected susceptibility genes for schizophrenia
Maier W, et al.
Dialogues Clin Neurosci 2006;8(1):79-84

Pharmacogenetics of the human beta-adrenergic receptors
Taylor MR
Pharmacogenomics J 2006 Apr

Polymorphisms in candidate genes: implications for the current treatment of Parkinson's disease
Skipper L, et al.
Expert Opin Pharmacother 2006 May;7(7):849-55

Genetic Testing and Private Insurance - A Case of "Selling One's Body"?
Hubner D
Med Health Care Philos 2006;9(1):43-55

Genetic susceptibility to neonatal infection
Strunk T & Burgner D
Curr Opin Infect Dis 2006 Jun;19(3):259-63

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 3, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Condition

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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Summer Institute in Statistical Genetics This reference links to a non-governmental website
June 12-30, 2006 ~ Seattle, WA
 

The 2006 CDC Diabetes and Obesity Conference This reference links to a non-governmental website
May 16-19, 2006 ~ Denver, Colorado

   
  9th Annual Meeting of the American Society of Gene Therapy
May 31 - June 4, 2006 ~ Baltimore, MD
   
New this week 10th Annual Child Neurology Congress
June 11-16, 2006 ~ Montreal, Canada
   
  Behavior Genetics Association 36th Annual Conference
June 20-24, 2006 ~ Storrs, CT
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Let's Go Surfing
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National Institute of Environmental Health Sciences Strategic Plan 2006 you will need a free Acrobat player to view this file
The National Institute of Environmental Health Sciences (NIEHS) completed a comprehensive strategic planning process resulting in the development of a new strategic plan. The five-year plan establishes seven overarching goals and identifies some of the major challenges confronting the field, including ways to enhance "integrative research" efforts.


Race, Genetics, and Health Care: What We Know and What It Means for Your PracticeThis reference links to a non-governmental website (last accessed 2/2008)
This project, funded by the Robert Wood Johnson and Josiah Macy, Jr. Foundations, will teach primary-care providers, and anyone who accesses the program via the NCHPEG website, about race, genetics, and health care.

Genetic Science Learning Center at the University of UtahThis reference links to a non-governmental website
The Genetic Science Learning Center is an outreach education program located in the midst of bioscience research at the University of Utah.

BlastThis reference links to a non-governmental website
Searches of protein or DNA sequence against metazoan genomes

CDC Birth Defects Activities in Genetics
Understanding genetic factors and genetic disorders is important in learning more about preventing birth defects.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
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This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: May 4, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics