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 Thursday, August 3, 2006     Volume 17   Number 5  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic discoveries on health care,  disease prevention and population health.
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Welcome to the National Office of Public Health Genomics
As of July 24, 2006, the CDC has changed the name of our office to the National Office of Public Health Genomics.

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CDC Announcements
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At-Home Genetic Tests: A Healthy Dose of Skepticism May Be the Best Prescription
Federal Trade Commission Consumer Alert

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Talk to Your Doctor or Healthcare Practitioner About Home Genetic Tests
Federal Trade Commission Press Release

CDC sponsored material HuGE What's New
August 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles. 
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“Different genes may cause autism in boys and girls” This reference links to a non-governmental website
(July 31) EurekAlert! reports, “Like detectives trying to solve a murder case, researchers searching for the biological cause of autism have come up with some surprising suspects.”

“SuperArray Bioscience Releases Over 36 Pathway-Focused Real-Time PCR Gene Panels For All Stages Of Drug Discovery And Development” This reference links to a non-governmental website
(Aug 3) Medical News Today reports, “SuperArray Bioscience (http://www.SuperArray.com) This reference links to a non-governmental website announced today that it will feature its real-time RT2ProfilerTM PCR Arrays at the upcoming Drug Discovery Technology meeting at the Boston World Trade Center and Seaport Hotel from August 8 to 10.”

“Bone marrow lesions in the knee may be hereditary” This reference links to a non-governmental website
(Aug 3) News-Medical.Net reports, “Bone marrow lesions in the knee, a cause of pain in patients with knee osteoarthritis, may be hereditary.”

“Increased odds of rheumatoid arthritis in women smokers without genetic risk factor” This reference links to a non-governmental website
(Aug 2) EurekAlert! reports, “Smoking increases the chance of developing rheumatoid arthritis in women who otherwise lack genetic risk factors for the disease, reveals research published ahead of print in the Annals of the Rheumatic Diseases. “

“Association between famine and schizophrenia may yield clues about inherited diseases and conditions” This reference links to a non-governmental website
(Aug 2) EurekAlert! reports, “The higher risk of schizophrenia among offspring of expectant mothers living through famine could help us understand the genetic basis for that debilitating mental disorder, a group of researchers argue in a commentary piece in the Aug. 2 issue of JAMA.”

“From complex pathways to patient care, the MNI attacks Parkinson’s disease from all sides” This reference links to a non-governmental website
(Aug 1) McGill reports, “As a world-class medical centre, the Montreal Neurological Institute and Hospital (MNI) at McGill University is able to treat patients with Parkinson’s and make important discoveries about the disease all under the same roof.”

“A team of Danish researchers has isolated a third gene linked to the development of breast cancer” This reference links to a non-governmental website (last accessed 2/2008)
(Aug 1) The Copenhagen Post Online reports, “Danish researchers have isolated a new gene responsible for breast cancer. A mutation of the gene can triple the risk of developing breast cancer.”

“Gene variations may increase stroke risk for younger women” This reference links to a non-governmental website
(Aug 1) EurekAlert! reports, “University of Maryland researchers have shown a strong association between specific genetic variations and an increased risk of stroke in younger women, adding to the growing evidence of possible genetic influences in stroke.”

“Gene Discovery May Shed Light On Kidney Diseases; Second Gene Found For Alagille Syndrome May Have Broader Role” This reference links to a non-governmental website
(Aug 1) Medical News Today reports, “In a finding that may have broader implications for understanding kidney disorders, genetics researchers at The Children's Hospital of Philadelphia have identified a second gene that gives rise to Alagille syndrome, a genetic developmental disease that affects multiple organs.”

“New insights into mouth cancers”
(Aug 1) Reuters Health reports, “Mouth cancer develops in two distinct ways which determine the seriousness of the disease, scientists said on Tuesday, a finding that could lead to new ways of preventing and treating it.”

“Researchers develop blood test to detect lung cancer” This reference links to a non-governmental website
(July 31) EurekAlert! reports, “Lung cancer is the leading cause of cancer death for both men and women in the United States and around the world, mainly because lung cancers are found in late stages and the best treatment opportunities already have been missed.”

“Study pinpoints how genetic glitch could keep some people from feeling full” This reference links to a non-governmental website
(July 31) EurekAlert! reports, “Nearly 6 percent of morbidly obese children and adults have a genetic defect that keeps them feeling like their stomach is running on empty, no matter how much they have eaten.”

“University of Pennsylvania Researchers Find Role for MicroRNAs in Oxygenation, Nourishing of Colon Tumors” This reference links to a non-governmental website
(July 31) University of Pennsylvania reports, “Researchers from the University of Pennsylvania School of Veterinary Medicine have identified how molecules of microRNA are responsible for the growth of blood vessels in a model for human colon cancer.”

“Gene families studied to explore diversity”  This reference links to a non-governmental website
(July 31) Daily India.com reports, “U.S. theoretical biologist Stephen Proulx is studying gene families to explore how genomes become diverse and evolve.”

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Genomics in Scientific Literature
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CDC sponsored material  Racial and Ethnic Disparity in Participation in DNA Collection at the Atlanta Site of the National Birth Defects Prevention Study
Crider KS, et al.
Am J Epidemiol 2006 Jul

A Description of the Process of Recruitment for Research Studies Investigating the Genetics of Psychotic Illness
Mathos KK, et al.
Curr Psychiatry Rep 2006 Jul;8(4):307-12

Genetic factors involved in the development of Helicobacter pylori-related gastric cancer
Hamajima N, et al.
Cancer Sci 2006 Aug

A Fast, Unbiased and Exact Allelic Test for Case-Control Association Studies
Guedj M, et al.
Hum Hered 2006 Jul;61(4):210-21

Pharmacogenetics of Uridine Diphosphoglucuronosyltransferase (UGT) 1A Family Members and its Role in Patient Response to Irinotecan*
Nagar S & Blanchard RL
Drug Metab Rev 2006;38(3):393-409

Applying pharmacogenomics to enhance the use of biomarkers for drug effect and drug safety
Beitelshees AL & McLeod HL
Trends Pharmacol Sci 2006 Jul

Twenty-three novel BRCA1 and BRCA2 sequence variations identified in a cohort of Swiss breast and ovarian cancer families
Maillet P, et al.
Cancer Genet Cytogenet 2006 Aug;169(1):62-8

The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features
Locker GY, et al.
Cancer Genet Cytogenet 2006 Aug;169(1):33-8

Medico-genetic prediction of cerebral stroke risk
Klin Med (Mosk) 2006;84(6):49-51

Study design options in evaluating gene-environment interactions: Practical considerations for a planned case-control study of pediatric leukemia
Goodman M & Dana Flanders W
Pediatr Blood Cancer 2006 Jul

Genetic variants and the risk of Crohn's disease: what does it mean for future disease management?
Torok HP, et al.
Expert Opin Pharmacother 2006 Aug;7(12):1591-602

Pharmacogenetics of antiarrhythmic therapy
Darbar D & Roden DM
Expert Opin Pharmacother 2006 Aug;7(12):1583-90

K-ras Mutations in Non-Small-Cell Lung Carcinoma: A Review
Aviel-Ronen S, et al.
Clin Lung Cancer 2006 Jul;8(1):30-8

National and ethnic mutation databases: recording populations' genography
Patrinos GP
Hum Mutat 2006 Jul

Genetic variants and common diseases--better late than never
O'Rahilly S & Wareham NJ
N Engl J Med 2006 Jul;355(3):306-8

Family History
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Family history of breast cancer as a risk factor for ovarian cancer in a prospective study
Kazerouni N, et al.
Cancer 2006 Jul

Lifestyle, family history and progression of hypertension
Winnicki M, et al.
J Hypertens 2006 Aug;24(8):1479-87

Genetic Testing
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“Agencies Warn Against "Take-Home" Genetic Tests” This reference links to a non-governmental website
(July 31) All Headline News reports, “The Federal Trade Commission (FTC), the Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC) want to warn the American public against some outrageous claims being made by makers of "take-home" genetic tests.”

“Genome Research Approves Genetic Screening” This reference links to a non-governmental website
(Aug 2) Scoop reports, “The Human Genome Research Project has reported positively on the use of a technique that allows implant embryos to be screened for genetic disorders.”

“New Genetic Test Ready for Prime Time?” This reference links to a non-governmental website
(Aug 1) POZ reports, “Independent Forensics, an Illinois-based company specializing in paternity testing and DNA evidence used in criminal investigations, has begun marketing a genetic assay intended for HIV-positive people.”

Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force
Whitlock EP, et al.
Ann Intern Med 2006 Aug;145(3):209-23

Clinical characteristics affect the impact of an uninformative DNA test result: the course of worry and distress experienced by women who apply for genetic testing for breast cancer
van Dijk S, et al.
J Clin Oncol 2006 Aug;24(22):3672-7

Comparison of individuals opting for BRCA1/2 or HNPCC genetic susceptibility testing with regard to coping, illness perceptions, illness experiences, family system characteristics and hereditary cancer distress
van Oostrom I, et al.
Patient Educ Couns 2006 Jul

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending August 2, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New This Week

First International Symposium on Usher Syndrome and Related Disorders This reference links to a non-governmental website
October 4-6, 2006 ~ Omaha, Nebraska

  11th International Congress of Human Genetics
August 6-10, 2006 ~ Brisbane, Australia
   
  The 8th International Meeting on Human Genome Variation and Complex Genome Analysis
September 14-16, 2006 ~ Hong Kong, China
   
  From Genomes to Protective Antigens: Designing Vaccines
November 15-17, 2006 ~ Prague, Czech Republic
   
New This Week 5th International Conference on Bioinformatics & Biotechnology-InCob2006 This reference links to a non-governmental website (last accessed 2/2008)
December 18-20, 2006 ~ New Delhi, India
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Let's Go Surfing
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Ask the Geneticist This reference links to a non-governmental website
A collaboration between the Department of Human Genetics at Emory University and the Department of Genetics at the University of Alabama at Birmingham with the mission to answer questions about genetic concepts, and the etiology, treatment, research, testing, and predisposition to genetic disorders.

The Gene Scene This reference links to a non-governmental website
American Museum of Natural History site for children

Department of Genetics This reference links to a non-governmental website
University of Cambridge

 

 

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: August 3, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics