Most published research findings are false--but a little replication goes a long way (last accessed 2/2008)
Ramal Moonesinghe, Muin J. Khoury, A. Cecile J. W. Janssens
PLoS Medicine (February 2007)

One new HuGE Review has been posted on the HuGENet™ website since the last issue of ‘What's New':

Myeloperoxidase G-463A polymorphism and lung cancer: A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis (221KB) by Emanuela Taioli, et al., from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC)
Genetics in Medicine (February 2007).

Two new HuGE Reviews were proposed in February:

• Serotonin transporter (5HTT) Gene polymorphisms and risk of depression
  Simon Gilbody (University of York, UK)
• TCF7L2 gene and Type 2 Diabetes
  Adam Butterworth, Gurdeep Sagoo and Julian Higgins (UK HuGENet Coordinating Centre and Public Health Genetics Unit, Cambridge, UK)

• List of completed HuGE Reviews
• List of HuGE Review topics under development

Handbook for Authors of New HuGE Reviews
HuGENet™ released the first edition of the HuGENet™ Handbook of Systematic
Reviews ((165KB)) in March 2006. All new HuGE reviews should follow the guidance in this document.

Numerous collaborative networks of investigators are undertaking meta-analyses of literature and of individual-level data on gene-disease associations. HuGENet™ is building a global network of such networks to create a resource for information, offer methodological support, promote sound design and standardization of analytical practices, generate inclusive overviews of fields-at-large, facilitate rapid confirmation of findings, and avoid duplication of effort. Visit the HuGENet™ Network of Networks Website to learn more about this initiative and for information about how to join.

Please help us inform fellow members of any HuGE activities that may be of interest. Let us know about any upcoming research projects or meetings that pertain to the prevalence of gene variants, gene-disease association or similar HuGE topics. Please e-mail your comments to HuGE@cdc.gov. The information you send will be compiled and posted in a future edition of “What’s New?” 

As of March 1, 2007, the HuGENet™ website contains 25,857 research studies indexed in the HuGE Published Literature database, referencing 2,696 genes, 901 factors (personal or environmental), and 3,185 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 57 HuGE Reviews and 453 meta-analyses.  Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z.

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

Provides link to non-governmental sites and does not necessarily represent the  views of the Centers for Disease Control and Prevention.