This November, HuGENet UK will host a short course on how to undertake a HuGE systematic review. For more information, including a list of the faculty and topics to be covered, visit the HuGENet short course webpage. Please contact:

Jane Lane
HuGENet UK Coordinating Centre
Public Health Genetics Unit
Strangeways Research Laboratory
Worts Causeway
Cambridge CB1 8RN

Tel: +44 1223 742003
Email: jane.lane@srl.cam.ac.uk

Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium
Salanti G, et al.
Stat Med 2006 May

• View all HuGENet™ Publications and learn how to submit a paper for the HuGENet™ website

One new HuGE Review has been posted on the HuGENet™ website since the last issue of ‘What's New':

XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer: A HuGE Review by Maurizio Manuguerra et al. from the Institute for Scientific Interchange Foundation American Journal of Epidemiology Advance Access (May 2006)

Two new HuGE Case Studies have been published in June:

• Multiple genetic testing for susceptibility to common disease: PPARG and CAPN10 SNP’s and type 2 diabetes

• Evaluation of the TCFT7L2 gene as a predictor of type 2 diabetes

HuGENet™ released the first edition of the HuGENet™ Handbook of Systematic Reviews in March 2006. All new HuGE reviews should follow the guidance in this document.
Guidelines for submitting HuGE Reviews

• List of completed HuGE Reviews
• List of HuGE Review topics under development

This month HuGENet is pleased to spotlight the P3G Observatory based at the Public Population Project in Genomics (P3G).  This knowledge source contains a catalog of population genomic epidemiologic studies as well as detailed questionnaire information.

If you are a HuGENet™ collaborator and have a web page you would like to showcase, please email HuGE@cdc.gov. Indicate in your subject heading "HuGENet™ collaborator home page."

• View the entire list of HuGENet™ Collaborators
• Learn how to become a HuGENet™ collaborator

Please help us inform fellow members of any HuGE activities that may be of interest. Let us know about any upcoming research projects or meetings that pertain to the prevalence of gene variants, gene-disease association or similar HuGE topics. Please e-mail your comments to HuGE@cdc.gov. The information you send will be compiled and posted in a future edition of “What’s New?”

As of June 1, 2006, the HuGENet™ website contains 21,610 research studies indexed in the HuGE Published Literature database, referencing 2,379 genes, 796 factors (personal or environmental), and 2,608 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 278 meta-analyses and 94 pooled analyses.  Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z. 

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

Provides link to non-governmental sites and does not necessarily represent the views of the  Centers for Disease Control and Prevention.