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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
September 11, 2008
Volume 21, No. 11

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

Polymorphism of HLA-DRB1, -DQB1 and -DPB1 genes in Bai ethnic group in southwestern China
Hu W, et al.
Tissue Antigens 2008 Sep

[HLA-DM polymorphisms in Guizhou Han individuals.]
Jiang HM, et al.
Yi Chuan 2008 Sep;30(9):1153-6

Different Allelic Distribution of a Single SNP Between Sexes in Humans
Tripputi P, et al.
Biochem Genet 2008 Sep

Duplex pyrosequencing of the TPMT3C and TPMT6 alleles in Korean and Vietnamese populations
Lee SS, et al.
Clin Chim Acta 2008 Aug

Determination of TAP1 and TAP2 polymorphism in the Chinese Han population by real-time TaqMan polymerase chain reaction
Feng ML, et al.
Tissue Antigens 2008 Aug

 

Infectious and Parasitic Diseases

Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil
Franceschi DS, et al.
Tissue Antigens 2008 Sep

Influence of the Toll-Like Receptor 9 1635A/G Polymorphism on the CD4 Count, HIV  Viral Load, and Clinical Progression
Soriano-Sarabia N, et al.
J Acquir Immune Defic Syndr 2008 Sep

Effect of concomitant artesunate administration and CYP2C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria
Adjei GO, et al.
Antimicrob Agents Chemother 2008 Sep

 

Neoplasms

ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy
Johnatty SE, et al.
Clin Cancer Res 2008 Sep;14(17):5594-601

Associations between XPC polymorphisms and risk of cancers: A meta-analysis
Qiu L, et al.
Eur J Cancer 2008 Sep

No Association of MMP-7, MMP-8, and MMP-21 Polymorphisms with the Risk of Hepatocellular Carcinoma in a Chinese Population
Qiu W, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2514-8

Association between polymorphisms in the GSTA4 gene and risk of lung cancer: A case-control study in a Southeastern Chinese population
Qian J, et al.
Mol Carcinog 2008 Sep

Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists
Rajaraman P, et al.
Int J Cancer 2008 Sep

Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases
Robbins CM, et al.
Prostate 2008 Sep

Genetic Variation in Genes for the Xenobiotic-Metabolizing Enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and Susceptibility to Colorectal Cancer in Lynch Syndrome
Pande M, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2393-401

Pharmacogenetic study in Hodgkin's lymphomas reveals the impact of UGT1A1 polymorphisms on patient's prognosis
Ribrag V, et al.
Blood 2008 Sep

A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk
Lao T, et al.
Mutagenesis 2008 Sep

Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer
Halfdanarson TR, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2512-3

Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer
Cramer SD, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2451-7

CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population
Sam SS, et al.
Head Neck 2008 Sep

The SRD5A2 V89L polymorphism is associated with severity of disease in men with early onset prostate cancer
Scariano JK, et al.
Prostate 2008 Sep

Association between Polymorphisms in DNA Base Excision Repair Genes XRCC1, APE1,  and ADPRT and Differentiated Thyroid Carcinoma
Chiang FY, et al.
Clin Cancer Res 2008 Sep

Talc Use, Variants of the GSTM1, GSTT1, and NAT2 Genes, and Risk of Epithelial Ovarian Cancer
Gates MA, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2436-44

MTHFR Genotype and Colorectal Adenoma Recurrence: Data from a Double-blind Placebo-controlled Clinical Trial
Levine AJ, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2409-15

Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma
Canedo P, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2416-20

[The relationship between the polymorphism of MUC1 and suscepti-bility to gastric cancer in Liaoning region.]
Xu Q, et al.
Yi Chuan 2008 Sep;30(9):1163-8

Genetic polymorphisms of the e-cadherin promoter and risk of sporadic gastric carcinoma in chinese populations
Zhang B, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2402-8

Common 8q24 sequence variations are associated with asian Indian advanced prostate cancer risk
Tan YC, et al.
Cancer Epidemiol Biomarkers Prev 2008 Sep;17(9):2431-5

Combined Polymorphism Analysis of Glutathione S-transferase M1/G1 and Interleukin-1B (IL-1B)/Interleukin 1-Receptor Antagonist (IL-1RN) and Gastric Cancer Risk in an Omani Arab Population
Al-Moundhri MS, et al.
J Clin Gastroenterol 2008 Sep

 

Endocrine, Nutritional and Metabolic Diseases

Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
Resic-Lindehammer S, et al.
Acta Diabetol 2008 Sep

Physical Activity and the Association of Common FTO Gene Variants With Body Mass  Index and Obesity
Rampersaud E, et al.
Arch Intern Med 2008 Sep;168(16):1791-7

Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study
Hivert MF, et al.
Diabetes 2008 Sep

Type 2 diabetes mellitus and its renal complications in relation to apolipoprotein E gene polymorphism
Ma SW, et al.
Transl Res 2008 Sep;152(3):134-42

Association of the melanocortin-4 receptor V103I polymorphism with dietary intake in severely obese persons
Pichler M, et al.
Am J Clin Nutr 2008 Sep;88(3):797-800

AKT2: First Evidence of Genetic Association with Polycystic Ovary Syndrome
Goodarzi MO, et al.
Diabetes Care 2008 Sep

APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia
Wang J, et al.
Nat Clin Pract Cardiovasc Med 2008 Sep

 

Mental Disorders

Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers
Chen GB, et al.
Hum Genet 2008 Sep

The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population
Sun N, et al.
J Neural Transm 2008 Sep

Association of maternal dopamine transporter genotype with negative parenting: evidence for gene x environment interaction with child disruptive behavior
Lee SS, et al.
Mol Psychiatry 2008 Sep

Attention deficit hyperactivity disorder in obese melanocortin-4-receptor (MC4R)  deficient subjects: A newly described expression of MC4R deficiency
Agranat-Meged A, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations
Yamada K, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

 

Diseases of the Nervous System and Sense Organs

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration
Ghidoni R, et al.
Neurology 2008 Sep

Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine
Scacchi R, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Sep

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility
Chao MJ, et al.
Proc Natl Acad Sci U S A 2008 Sep;105(35):13069-74

 

Diseases of the Circulatory System

Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm
Smallwood L, et al.
Br J Surg 2008 Oct;95(10):1239-44

Evidence for Involvement of Calcitonin Gene-Related Peptide in Nitroglycerin Response and Association With Mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) Glu504Lys Polymorphism
Guo R, et al.
J Am Coll Cardiol 2008 Sep;52(11):953-60

Common Genetic Polymorphisms and Haplotypes of Fibrinogen Alpha, Beta, and Gamma  Chains Affect Fibrinogen Levels and the Response to Proinflammatory Stimulation in Myocardial Infarction Survivors The AIRGENE Study
Jacquemin B, et al.
J Am Coll Cardiol 2008 Sep;52(11):941-52

Association between Val/Leu(247) polymorphism of apolipoprotein H and cerebral infarction in a Chinese population
Xia J, et al.
J Thromb Thrombolysis 2008 Sep

Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study
Caslake MJ, et al.
Am J Clin Nutr 2008 Sep;88(3):618-29

Evaluation of potential modifiers of the cardiac phenotype in the 22q11.2 deletion syndrome
Goldmuntz E, et al.
Birth Defects Res A Clin Mol Teratol 2008 Sep

Impact of beta1-Adrenergic Receptor Polymorphisms on Susceptibility to Heart Failure, Arrhythmogenesis, Prognosis, and Response to Beta-Blocker Therapy
Biolo A, et al.
Am J Cardiol 2008 Sep;102(6):726-32

 

Diseases of the Respiratory System

Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is  associated with asthma susceptibility in Chinese children
Wang J, et al.
Mol Biol Rep 2008 Sep

Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis  in a Chinese Han population
Su DJ, et al.
BMC Med Genet 2008 Sep;9(1):82

Correlation between genetic polymorphism of cytokine genes, plasma protein levels and bronchial asthma in the han people in northern china
Xiaomin L, et al.
J Asthma 2008 Sep;45(7):583-9

 

Diseases of the Digestive System

Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers
Shieh TM, et al.
J Oral Pathol Med 2008 Sep



Diseases of the Genitourinary System

Polymorphism of the aldosterone synthase gene is not associated with progression  of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients
Ko GJ, et al.
Nephrology (Carlton) 2008 Sep

No Association between T222P/LGR8 Mutation and Cryptorchidism in the Moroccan Population
El Houate B, et al.
Horm Res 2008 Sep;70(4):236-9

Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility
Aydos SE, et al.
Fertil Steril 2008 Sep

Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy
Savage DA, et al.
Diabetologia 2008 Sep

 

Complications of Pregnancy, Childbirth, and the Puerperium

Association of cyclooxygenase-2 and interleukin-1 receptor antagonist gene polymorphisms with the time interval between labor induction and delivery
Skupski DW, et al.
Am J Obstet Gynecol 2008 Sep;199(3):296.e1-5

Thrombin-activatable fibrinolysis inhibitor polymorphisms and recurrent pregnancy loss
Masini S, et al.
Fertil Steril 2008 Sep

One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency
Furness DL, et al.
Am J Obstet Gynecol 2008 Sep;199(3):276.e1-8

 

Diseases of the Skin and Subcutaneous Tissue

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk
Weidinger S, et al.
J Allergy Clin Immunol 2008 Sep;122(3):560-8.e4

 

Diseases of the Musculoskeletal System and Connective Tissue

Relationship between single nucleotide polymorphisms in CYP1A1 and CYP1B1 genes and the bone mineral density and serum lipid profiles in postmenopausal Japanese  women taking hormone therapy
Quan J, et al.
Menopause 2008 Sep

Interleukin-17F gene polymorphisms in Korean patients with Behcet's disease
Jang WC, et al.
Rheumatol Int 2008 Sep

No significant association between genetic polymorphisms in the TNAP gene and ankylosing spondylitis in the Chinese Han population
Cheng N, et al.
Rheumatol Int 2008 Sep


Congenital Anomalies

Association of Bone Morphogenetic Protein 4 Gene Polymorphisms with Nonsyndromic  Cleft Lip with or without Cleft Palate in Chinese Children
Lin JY, et al.
DNA Cell Biol 2008 Sep

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects
Christensen KE, et al.
Hum Mutat 2008 Sep

 

Certain Conditions Originating in the Perinatal Period

HTR2A variation and sudden infant death syndrome: a case-control analysis
Rand CM, et al.
Acta Paediatr 2008 Sep

 

Symptoms, Signs and Ill-defined Conditions

FOXO3A genotype is strongly associated with human longevity
Willcox BJ, et al.
Proc Natl Acad Sci U S A 2008 Sep

 

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Page last reviewed: September 11, 2008 (archived document)
Content Source: National Office of Public Health Genomics