Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 

HugeNet™

Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
December 13, 2007
Volume 19, No. 23

Return to Weekly Update

Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Distribution of the GNB3 825C>T polymorphism among Brazilians: impact of population structure
Vargens DD, et al.
Eur J Clin Pharmacol 2007 Dec

 

Infectious and Parasitic Diseases

Analysis of the 5q31 33 Locus Shows an Association between Single Nucleotide Polymorphism Variants in the IL-5 Gene and Symptomatic Infection with the Human Blood Fluke, Schistosoma japonicum
Ellis MK, et al.
J Immunol 2007 Dec;179(12):8366-71

Interleukin-10 and Tumor Necrosis Factor-alpha Gene Polymorphisms in Tuberculosis
Ates O, et al.
J Clin Immunol 2007 Dec

[Role of HLA-DR and HLA-DQ alleles in multibacillary leprosy and paucibacillary leprosy in the province of Chaco (Argentina).]
Motta PM, et al.
Enferm Infecc Microbiol Clin 2007 Dec;25(10):627-31

Significance of Transporter Associated with Antigen Processing 2 (TAP2) Gene Polymorphisms in Susceptibility to Dengue Viral Infection
Soundravally R & Hoti SL
J Clin Immunol 2007 Dec

Novel insight in the association between salmonellosis or campylobacteriosis and  chronic illness, and the role of host genetics in susceptibility to these diseases
Doorduyn Y, et al.
Epidemiol Infect 2007 Dec:1-10

 

Neoplasms

FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer
Kang S, et al.
Cancer Genet Cytogenet 2008 Jan;180(1):1-5

Identification of polymorphisms in the XIAP gene and analysis of association with lung cancer risk in a Korean population
Kang HG, et al.
Cancer Genet Cytogenet 2008 Jan;180(1):6-13

A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
Lee YC, et al.
Int J Cancer 2007 Dec

Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results  from the Colon Cancer Family Registry
Poynter JN, et al.
Cancer Res 2007 Dec;67(23):11128-32

Leptin and leptin receptor genotypes and colon cancer: Gene-gene and gene-lifestyle interactions
Slattery ML, et al.
Int J Cancer 2007 Dec

Genetic Variants of Glutathione S-Transferase as Possible Risk Factors for Hepatocellular Carcinoma: A HuGE Systematic Review and Meta-Analysis
White DL, et al.
Am J Epidemiol 2007 Dec

Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population
Shao M, et al.
Lung Cancer 2007 Dec

Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
Sharp L, et al.
Br J Nutr 2007 Dec:1-11

MC1R variants associated susceptibility to basal cell carcinoma of skin: Interaction with host factors and XRCC3 polymorphism
Scherer D, et al.
Int J Cancer 2007 Dec

Lack of association of NQO1 and GSTP1 polymorphisms with multiple myeloma risk
Maggini V, et al.
Leuk Res 2007 Dec

Receptor for advanced glycation end products (RAGE)--soluble form (sRAGE) and gene polymorphisms in patients with breast cancer
Tesarova P, et al.
Cancer Invest 2007 Dec;25(8):720-5

Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population
Kummee P, et al.
J Viral Hepat 2007 Dec;14(12):841-8

TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy
Rajkumar T, et al.
Breast Cancer Res Treat 2007 Dec

Transforming growth factor-beta 1 gene polymorphisms and expression in the blood  of prostate cancer patients
Faria PC, et al.
Cancer Invest 2007 Dec;25(8):726-32

Comprehensive Association Testing of Common Genetic Variation in DNA Repair Pathway Genes in Relationship with Breast Cancer Risk in Multiple Populations
Haiman CA, et al.
Hum Mol Genet 2007 Dec

Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations
Kleibl Z, et al.
Breast Cancer Res Treat 2007 Dec

Polymorphisms in xenobiotic-metabolizing genes and the risk of chronic lymphocytic leukemia and non-Hodgkin's lymphoma in adult Russian patients
Gra OA, et al.
Am J Hematol 2007 Dec

The RAD51D E233G variant and breast cancer risk: population-based and clinic-based family studies of Australian women
Dowty JG, et al.
Breast Cancer Res Treat 2007 Dec

Vitamin D receptor polymorphisms and breast cancer risk in a large population-based case control study of Caucasian and African-American women
Trabert B, et al.
Breast Cancer Res 2007 Dec;9(6):R84

Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French Canadian women
Foulkes WD, et al.
Breast Cancer Res 2007 Dec;9(6):R83

A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort
Lee SA, et al.
BMC Med Genet 2007 Dec;8(1):72

CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer
Zhang Z, et al.
Cancer Res 2007 Dec;67(23):11202-8

 

Endocrine, Nutritional and Metabolic Diseases

Genetic Variation and Association Analyses of the Nuclear Respiratory Factor 1 (NRF1) Gene in Chinese Patients with Type 2 Diabetes
Liu Y, et al.
Diabetes 2007 Dec

Association of ADRB1 and UCP3 Gene Polymorphisms with Insulin Sensitivity but Not Obesity
Mottagui-Tabar S, et al.
Horm Res 2007 Dec;69(1):31-6

The DG10S478 Variant in the TCF7L2 Gene is not Associated with Microvascular Complications in Type 2 Diabetes
Buchbinder S, et al.
Exp Clin Endocrinol Diabetes 2007 Dec

Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan
Chen PL, et al.
Genes Immun 2007 Dec

Lack of association between interleukin-4 gene polymorphisms and autoimmune thyroid diseases amongst Taiwanese Chinese
Chen RH, et al.
Endocrine 2007 Dec

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
Florez JC, et al.
Diabetologia 2007 Dec

The Hand Arthropathy of Hereditary Hemochromatosis Is Strongly Associated with Iron Overload
Valenti L, et al.
J Rheumatol 2007 Dec

Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations
Gombos Z, et al.
Eur J Endocrinol 2007 Dec;157(6):757-61

Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
Scott EM, et al.
Int J Obes (Lond) 2007 Dec

Variants in the FTO gene are associated with common obesity in the Belgian population
Peeters A, et al.
Mol Genet Metab 2007 Dec

Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective  cohort study
Conen D, et al.
J Intern Med 2007 Dec

The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1
Husain Z, et al.
J Autoimmun 2007 Dec

Influence of the Trp64Arg polymorphism in the beta 3 adrenoreceptor gene on insulin resistance, adipocytokine response, and weight loss secondary to lifestyle modification in obese patients
de Luis DA, et al.
Eur J Intern Med 2007 Dec;18(8):587-92

Interactions between Idd5.1/Ctla4 and Other Type 1 Diabetes Genes
Hunter K, et al.
J Immunol 2007 Dec;179(12):8341-9

Genetic Variation of Neurogenin 3 is Slightly Associated with Hyperproinsulinaemia and Progression Toward Type 2 Diabetes
Li J, et al.
Exp Clin Endocrinol Diabetes 2007 Dec

Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis - a cohort study
Nilsson M, et al.
BMC Med Genet 2007 Dec;8(1):73

The association between the IFIH1 locus and type 1 diabetes
Qu HQ, et al.
Diabetologia 2007 Dec

 

Mental Disorders

Association of Interleukin-10 gene promoter polymorphisms in Saudi patients with  Vitiligo
Abanmi A, et al.
Dis Markers 2008;24(1):51-7

Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: Analysis of pooled data from two clinical trials
David SP, et al.
Nicotine Tob Res 2007 Dec;9(12):1251-7

DRD2/ANKK1 TaqI polymorphism and smoking behavior of Egyptian male cigarette smokers
Radwan GN, et al.
Nicotine Tob Res 2007 Dec;9(12):1325-9

Major Genetic Components Underlying Alcoholism in Korean Population
Kim DJ, et al.
Hum Mol Genet 2007 Dec

Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder
Yoshimi A, et al.
Schizophr Res 2007 Dec

Genetic examination of the PLXNA2 gene in Japanese and Chinese schizophrenics
Takeshita M, et al.
Schizophr Res 2007 Dec

 

Diseases of the Nervous System and Sense Organs

Manganese superoxide dismutase gene polymorphism (V16A) is associated with diabetic retinopathy in Slovene (Caucasians) type 2 diabetes patients
Petrovic MG, et al.
Dis Markers 2008;24(1):59-64

SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese
Tan EK, et al.
Neurobiol Aging 2007 Dec

Peripheral Reticular Pigmentary Change Is Associated with Complement Factor H Polymorphism (Y402H) in Age-Related Macular Degeneration
Shuler RK Jr, et al.
Ophthalmology 2007 Dec

Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population
Lynch CA, et al.
Ir J Med Sci 2007 Dec

TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease
Culpan D, et al.
Neurobiol Aging 2007 Dec

Evidence that Common Variation in NEDD9 is Associated with Susceptibility to Late-onset Alzheimer's and Parkinson's Disease
Li Y, et al.
Hum Mol Genet 2007 Dec

APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study
Delano-Wood L, et al.
Int J Geriatr Psychiatry 2007 Dec

HLA-DRB1 and multiple sclerosis in Malta
Dean G, et al.
Neurology 2007 Dec

ALpha 7 Nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease
Carson R, et al.
J Med Genet 2007 Dec

Glaucoma-Associated CYP1B1 Mutations Share Similar Haplotype Backgrounds in POAG  and PACG Phenotypes
Chakrabarti S, et al.
Invest Ophthalmol Vis Sci 2007 Dec;48(12):5439-44

 

Diseases of the Circulatory System

The 677 C/T MTHFR Polymorphism is Associated with Essential Hypertension, Coronary Artery Disease, and Higher Homocysteine Levels
Ilhan N, et al.
Arch Med Res 2008 Jan;39(1):125-30

Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS)
Abdollahi MR, et al.
Dis Markers 2008;24(1):11-7

The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions
Pons D, et al.
Thromb Haemost 2007 Dec;98(6):1323-8

A common VLDLR polymorphism interacts with APOE in the prediction of carotid artery disease
Crawford DC, et al.
J Lipid Res 2007 Dec

GATA4 sequence variants in patients with congenital heart disease
Tomita-Mitchell A, et al.
J Med Genet 2007 Dec;44(12):779-83

ICAM-1 Polymorphisms (G241R, K469E), in Coronary Artery Disease and Myocardial Infarction
Aminian B, et al.
Iran J Immunol 2007 Dec;4(4):227-35

Acute myocardial infarction and proinflammatory gene variants
Licastro F, et al.
Ann N Y Acad Sci 2007 Dec;1119:227-42

Fibrinogen A{alpha}Thr312Ala polymorphism is associated with Chronic Thromboembolic Pulmonary Hypertension
Suntharalingam J, et al.
Eur Respir J 2007 Dec

Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk
Gellekink H, et al.
Thromb Haemost 2007 Dec;98(6):1226-31

Association of Human Platelet Alloantigen 1 through 5 Polymorphisms with Ischemic Stroke
Saidi S, et al.
Cerebrovasc Dis 2007 Dec;25(1-2):81-6

Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery  atherosclerosis: The Helsinki Sudden Death Study
Ilveskoski E, et al.
Atherosclerosis 2007 Dec

Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women
Jensen MK, et al.
Eur Heart J 2007 Dec

Polymorphisms of Human Leukocyte Antigen Genes in Korean Children with Kawasaki Disease
Oh JH, et al.
Pediatr Cardiol 2007 Dec

Sex-specific association of fatty acid binding protein 2 and microsomal triacylglycerol transfer protein variants with response to dietary lipid changes  in the 3-mo Medi-RIVAGE primary intervention study
Gastaldi M, et al.
Am J Clin Nutr 2007 Dec;86(6):1633-41

Ile164 variant of beta2-adrenoceptor does not influence outcome in heart failure  but may interact with beta blocker treatment
Littlejohn MD, et al.
Eur J Heart Fail 2007 Dec

The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans
Grewal RP, et al.
BMC Med Genet 2007 Dec;8(1):76

Study of the Relationship between Gene Polymorphisms of Paraoxonase 2 and Stroke  in a Chinese Population
Xu HW, et al.
Cerebrovasc Dis 2007 Dec;25(1-2):87-94

 

Diseases of the Respiratory System

The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population-based, longitudinal birth cohort
Granell R, et al.
Clin Exp Allergy 2007 Dec

Glutathione-S transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults
Imboden M, et al.
Thorax 2007 Dec

Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome
Villar J, et al.
Intensive Care Med 2007 Dec

 

Diseases of the Genitourinary System

Matrix Metalloproteinase-2, -9, and -12 Gene Polymorphisms in Generalized Aggressive Periodontitis
Gurkan A, et al.
J Periodontol 2007 Dec;78(12):2338-47

CD209 in inflammatory bowel disease: a case-control study in the Spanish population
Nunez C, et al.
BMC Med Genet 2007 Dec;8(1):75

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Rosendahl J, et al.
Nat Genet 2007 Dec

Trypsinogen Copy Number Mutations in Patients With Idiopathic Chronic Pancreatitis
Masson E, et al.
Clin Gastroenterol Hepatol 2007 Dec

 

Diseases of the Genitourinary System

XPC gene polymorphisms and risk of idiopathic azoospermia or oligozoospermia in a Chinese population
Liang J, et al.
Int J Androl 2007 Dec

Gene polymorphisms and male infertility - a meta-analysis and literature review
Tuttelmann F, et al.
Reprod Biomed Online 2007 Dec;15(6):643-58

The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis
Kim JY, et al.
Eur J Obstet Gynecol Reprod Biol 2007 Dec

 

Complications of Pregnancy, Childbirth, and the Puerperium

The 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is not associated with HELLP syndrome
Muetze S, et al.
J Thromb Thrombolysis 2007 Dec

Low organic solvent exposure and combined maternal-infant gene polymorphisms affect gestational age
Qin X, et al.
Occup Environ Med 2007 Dec

 

Diseases of the Skin and Subcutaneous Tissue

Association of TNF polymorphisms with sarcoidosis, its prognosis and tumour necrosis factor (TNF)-alpha levels in Asian Indians
Sharma S, et al.
Clin Exp Immunol 2007 Dec

 

Diseases of the Musculoskeletal System and Connective Tissue

Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study
Hoegh SV, et al.
Scand J Immunol 2008 Jan;67(1):71-6

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Graham DS, et al.
Nat Genet 2007 Dec

Comprehensive Evaluation of the Genetic Variants of Interferon Regulatory Factor  5 Reveals a Novel 5bp Length Polymorphism as Strong Risk Factor for Systemic Lupus Erythematosus
Sigurdsson S, et al.
Hum Mol Genet 2007 Dec

Prospective meta-analysis of IL-1 gene complex polymorphisms confirms associations with ankylosing spondylitis
Sims AM, et al.
Ann Rheum Dis 2007 Dec

The Interleukin-1 and Fcgamma Receptor Gene Polymorphisms in Japanese Patients With Rheumatoid Arthritis and Periodontitis
Kobayashi T, et al.
J Periodontol 2007 Dec;78(12):2311-8

Polymorphisms in the Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5) Gene Are Associated with Peak Bone Mass in Non-sedentary Men: Results from the Odense Androgen Study
Brixen K, et al.
Calcif Tissue Int 2007 Dec

Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population
Kamatani Y, et al.
J Hum Genet 2007 Dec

The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows  suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases
Eike MC, et al.
Ann Rheum Dis 2007 Dec

IkappaBalpha Promoter Polymorphisms in Patients with Systemic Lupus Erythematosus
Lin CH, et al.
J Clin Immunol 2007 Dec

IL4 in the 5q31 context: association studies of type 1 diabetes and rheumatoid arthritis in the Spanish population
Nunez C, et al.
Immunogenetics 2007 Dec

Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome
Winkelmann J, et al.
Mov Disord 2007 Nov

 

Congenital Anomalies

MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children
Meguid NA, et al.
Dis Markers 2008;24(1):19-26

 

Certain Conditions Originating in the Perinatal Period

Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R Study
Mook-Kanamori DO, et al.
Eur J Endocrinol 2007 Dec;157(6):741-8

 

Symptoms, Signs and Ill-defined Conditions

Endothelial nitric oxide synthase gene polymorphism and elite endurance athlete status: the Genathlete study
Wolfarth B, et al.
Scand J Med Sci Sports 2007 Dec

 

Injury and Poisoning

GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study
Breton CV, et al.
Environ Health 2007 Dec;6(1):39

 

For more information on HuGE, please visit the HuGENet™ home page

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC National Office of Public Health Genomics makes available the above information as a public service only.
Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

Page last reviewed: December 13, 2007 (archived document)
Content Source: National Office of Public Health Genomics