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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
September 14, 2006
Volume 17, No. 11

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Clinical Heterogeneity of the LRRK2 G2019S Mutation
Papapetropoulos S, et al.
Arch Neurol 2006 Sep;63(9):1242-6

 

Infectious and Parasitic Diseases

Synergy between mannose-binding lectin gene polymorphisms and supplementation with vitamin A influences susceptibility to HIV infection in infants born to HIV-positive mothers
Kuhn L, et al.
Am J Clin Nutr 2006 Sep;84(3):610-5

Polymorphisms in Cytokine Genes and Risk of Helicobacter pylori Infection among Jamaican Children
Tseng FC, et al.
Helicobacter 2006 Oct;11(5):425-30

Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis
Oral HB, et al.
Cytokine 2006 Sep

Prevalence of CXCR4 Tropism among Antiretroviral-Treated HIV-1-Infected Patients with Detectable Viremia
Hunt PW, et al.
J Infect Dis 2006 Oct;194(7):926-30

Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality
Kalckreuth V, et al.
J Infect Dis 2006 Oct;194(7):949-57

Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy
Goulart LR, et al.
FEMS Immunol Med Microbiol 2006 Oct;48(1):91-8

The effect of stromal cell-derived factor 1 (SDF1/CXCL12) genetic polymorphism on HIV-1 disease progression
Vissoci Reiche EM, et al.
Int J Mol Med 2006 Oct;18(4):785-93

           

 

Neoplasms

Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions
Manuguerra M, et al.
Carcinogenesis 2006 Sep

Peroxisome profilerator-activated receptor{gamma}2 Pro12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes
Vogel U, et al.
Carcinogenesis 2006 Sep

Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese
Kuriki K, et al.
Cancer Sci 2006 Sep

Clinical predictors versus epidermal growth factor receptor mutation in gefitinib-treated non-small-cell lung cancer patients
Han SW, et al.
Lung Cancer 2006 Sep

Vitamin d receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer
Murtaugh MA, et al.
Nutr Cancer 2006;55(1):35-43

Correlation of XPC Ala499Val and Lys939Gln Polymorphisms to Risks of Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma
Zhou RM, et al.
Ai Zheng 2006 Sep;25(9):1113-9

Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry
Bernstein JL, et al.
Hum Mutat 2006 Sep

The functional genetic variant Ile646Val located in the kinase binding domain of the A kinase anchoring protein 10 is associated with familial breast cancer
Wirtenberger M, et al.
Carcinogenesis 2006 Sep

Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin's lymphoma
Lightfoot TJ, et al.
Haematologica 2006 Sep;91(9):1222-7

No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study
Thyagarajan B, et al.
Cancer Detect Prev 2006 Sep

Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a chinese population
Wang L, et al.
Eur J Cancer 2006 Sep

Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer
Araki K, et al.
Cancer Sci 2006 Sep

Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
Nuckel H, et al.
Blood 2006 Sep

Association between the functional polymorphism in the matrix metalloproteinase-7 promoter and susceptibility to adult astrocytoma
Lu Z, et al.
Brain Res 2006 Sep

 

Endocrine, Nutritional and Metabolic Diseases

Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans
Richardson DK, et al.
Diabetologia 2006 Oct;49(10):2317-28

Polymorphisms in the Ghrelin Gene are Associated with Serum High-Density Lipoprotein Cholesterol Level and not with Type 2 Diabetes Mellitus in Koreans
Choi HJ, et al.
J Clin Endocrinol Metab 2006 Sep

Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sample
Zhao LJ, et al.
Hum Genet 2006 Sep

Extreme genetic risk for type 1A diabetes
Aly TA, et al.
Proc Natl Acad Sci U S A 2006 Sep

Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study
Wei Q, et al.
J Mol Med 2006 Sep

Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin
Fernandez-Real JM, et al.
Diabetologia 2006 Oct;49(10):2402-11

Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese
Tanahashi T, et al.
Hum Genet 2006 Sep

 

Diseases of the Blood & Blood-Forming Organ Disorders

Influence of Ggamma-158 --> and beta- (AT)x(T)y globin gene polymorphisms on HbF levels in Italian beta-thalassemia carriers and wild-type subjects
Guida V, et al.
Haematologica 2006 Sep;91(9):1275-6

ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia
Chaar V, et al.
Haematologica 2006 Sep;91(9):1277-8

 

Mental Disorders

Schizophrenia is not associated with the functional candidate gene ERBB3: Results from a case-control study
Kanazawa T, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep        

A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia
Li C, et al.
Neurosci Lett 2006 Sep

The dysbindin gene (DTNBP1) and schizophrenia: No support for an association in the Korean population
Joo EJ, et al.
Neurosci Lett 2006 Sep

Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology, and ERK signaling
Hashimoto R, et al.
Hum Mol Genet 2006 Sep

Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: Preferential transmission of the HTR2A 452His allele to affected boys
Guimaraes AP, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Further evidence of MAO-A gene variants associated with bipolar disorder
Muller DJ, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Association of OPRM1 A118G variant with the relative reinforcing value of nicotine
Ray R, et al.
Psychopharmacology (Berl) 2006 Sep

Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder
Schiffer HH & Heinemann SF
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Association of APOE Genetic Polymorphism with Cognitive Function and Suicide History in Geriatric Depression
Hwang JP, et al.
Dement Geriatr Cogn Disord 2006 Sep;22(4):334-8

Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
Wilhelm J, et al.
J Psychiatr Res 2006 Sep

The serotonin receptor HTR1B: Gene polymorphisms in attention deficit hyperactivity disorder
Ickowicz A, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Analysis of the 5HT-2A T102C receptor polymorphism and psychotic symptoms in Alzheimer's disease
Craig D, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients
Zai CC, et al.
Int J Neuropsychopharmacol 2006 Sep:1-13

Serotonin transporter genotype and acute subjective response to amphetamine
Lott DC, et al.
Am J Addict 2006 Sep-2006 Oct;15(5):327-35

Association between polymorphisms in serotonin 2C receptor gene and attention-deficit/hyperactivity disorder in Han Chinese subjects
Li J, et al.
Neurosci Lett 2006 Sep

Association study of genes involved in serotonergic signaling pathway and suicide completion
Videtic A, et al.
Psychiatr Danub 2006 Sep;18 Suppl 1:157

Season of birth variations as risk factor of suicide attempts and interaction with the serotonin transporter gene
Courtet P, et al.
Psychiatr Danub 2006 Sep;18 Suppl 1:75

Association of a Functional Polymorphism in the Serotonin Transporter Gene with Personality Traits in Females in a Polish Population
Dragan WL & Oniszczenko W
Neuropsychobiology 2006 Sep;54(1):45-50

Positive association of schizophrenia to JARID2 gene
Pedrosa E, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Analysis of the Association between Apolipoprotein D and Schizophrenia
Zhang X, et al.
Neuropsychobiology 2006 Sep;54(1):40-4

Association of polymorphisms in transduction pathways with suicide attempt in major psychoses
De Luca V, et al.
Psychiatr Danub 2006 Sep;18 Suppl 1:120-1

HTR2C, HTR1A, NOS-I and NOS-III gene variants in German and Italian suicide attempters and completers
Rujescu D, et al.
Psychiatr Danub 2006 Sep;18(Suppl-1):121

Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia
Watanabe Y, et al.
Psychiatry Clin Neurosci 2006 Oct;60(5):633-5

A triallelic serotonin transporter gene promoter polymorphism
Zalsman G, et al.
Psychiatr Danub 2006 Sep;18 Suppl 1:157

Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype
Scheid JM, et al.
Genes Brain Behav 2006 Sep

 

Diseases of the Nervous System and Sense Organs

CYP2C19 Polymorphism and Risk for Essential Tremor
Alonso-Navarro H, et al.
Eur Neurol 2006 Sep;56(2):119-23

Intron 2 (T/C) CYP46 Polymorphism Is Associated with Alzheimer's Disease in Chinese Patients
Li Y, et al.
Dement Geriatr Cogn Disord 2006 Sep;22(5-6):399-404

Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits
Ozturk A, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

APOE Genotype and Cholesterol Levels in Lewy Body Dementia and Alzheimer Disease: Investigating Genotype-Phenotype Effect on Disease Risk
Borroni B, et al.
Am J Geriatr Psychiatry 2006 Sep

Effects of SCA1, MJD, and DPRLA triplet repeat polymorphisms on cognitive phenotypes in a normal population of adolescent twins
Luciano M, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology
Blain JF, et al.
Eur J Neurosci 2006 Sep

Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy
Lorenz S, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population
Hiromatsu Y, et al.
Endocr J 2006 Sep

Genetic Variation in the Renin-Angiotensin System and Autonomic Nervous System Function in Young Healthy Japanese Subjects
Nishikino M, et al.
J Clin Endocrinol Metab 2006 Sep

The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease
Arawaka S, et al.
J Neurosci 2006 Sep;26(36):9227-38

Family-based association study of TPH1 and TPH2 polymorphisms in autism
Ramoz N, et al.
Am J Med Genet B Neuropsychiatr Genet 2006 Sep

 

Diseases of the Circulatory System

Association of RAGE Gene Polymorphisms with In-Stent Restenosis in Non-Diabetic Korean Population
Shim CY, et al.
Cardiology 2006 Sep;107(4):261-8

Association of a functional polymorphism in the CYP4A11 gene with systolic blood pressure in survivors of myocardial infarction
Mayer B, et al.
J Hypertens 2006 Oct;24(10):1965-70

Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease
Zschocke J, et al.
Mech Ageing Dev 2006 Sep

The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms
Pannu H, et al.
J Neurosurg 2006 Sep;105(3):418-23

Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects
Rossi GP, et al.
J Hypertens 2006 Oct;24(10):1955-63

 

Diseases of the Respiratory System

Relationship between neurokinin 2 receptor gene polymorphisms and serum vascular endothelial growth factor levels in patients with toluene diisocyanate-induced asthma
Ye YM, et al.
Clin Exp Allergy 2006 Sep;36(9):1153-60

Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan
Wang TN, et al.
Clin Exp Allergy 2006 Sep;36(9):1147-52

Role of interleukin-17F in chronic inflammatory and allergic lung disease
Hizawa N, et al.
Clin Exp Allergy 2006 Sep;36(9):1109-14

 

Diseases of the Digestive System

Evaluation of RANK/RANKL/OPG gene polymorphisms in aggressive periodontitis
Soedarsono N, et al.
J Periodontal Res 2006 Oct;41(5):397-404

CARD15 gene variants in aggressive periodontitis
Noack B, et al.
J Clin Periodontol 2006 Sep

Relationship between IL-1A polymorphisms and gingival overgrowth in renal transplant recipients receiving Cyclosporin A
Bostanci N, et al.
J Clin Periodontol 2006 Sep

Analysis of CFTR, SPINK1, PRSS1 and AAT Mutations in Children With Acute or Chronic Pancreatitis
Sobczynska-Tomaszewska A, et al.
J Pediatr Gastroenterol Nutr 2006 Sep;43(3):299-306

The Role of Vascular Endothelial Growth Factor (VEGF) in Inflammatory Bowel Disease
Ferrante M, et al.
Inflamm Bowel Dis 2006 Sep;12(9):870-8

SPINK1 gene mutations and pancreatitis in Japan
Shimosegawa T, et al.
J Gastroenterol Hepatol 2006 Oct;21 Suppl 3:S47-51

 

Diseases of the Genitourinary System

Antiproteinuric Effect of Losartan in Non-Diabetic Renal Disease Is Not Dependent on ACE Insertion/Deletion Polymorphism
Park HC, et al.
Kidney Blood Press Res 2006 Sep;29(4):216-24

Interleukin-1 alpha but not interleukin-1 beta gene polymorphism is associated with polycystic ovary syndrome
Kolbus A, et al.
J Reprod Immunol 2006 Sep

Study on DAZ Gene Copy Deletion in Severe Oligozoospermia Sperm Donor for ICSI
A ZC, et al.
Yi Chuan 2006 Sep;28(9):1057-60

 

Complications of Pregnancy, Childbirth, and the Puerperium

Relationship between polymorphisms in thrombophilic genes and preeclampsia in a Brazilian population
Dalmaz CA, et al.
Blood Cells Mol Dis 2006 Sep

 

Diseases of the Skin and Subcutaneous Tissue

Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes
Chang YT, et al.
Br J Dermatol 2006 Oct;155(4):663-9

 

Diseases of the Musculoskeletal System and Connective Tissue

Novel IL10 gene family Associations with Systemic Juvenile Idiopathic Arthritis (sJIA)
Fife MS, et al.
Arthritis Res Ther 2006 Sep;8(5):R148

Analysis of TIMP-1 Gene Polymorphisms in Italian Sclerodermic Patients
Indelicato M, et al.
J Clin Lab Anal 2006 Sep;20(5):173-6

Association of the F352V variant of the Klotho gene with bone mineral density
Riancho JA, et al.
Biogerontology 2006 Sep

 

Congenital Anomalies

Association of Long Polyglycine Tracts (GGN repeats) in Exon 1 of the Androgen Receptor Gene with Cryptorchidism and Penile Hypospadias in Iranian Patients
Radpour R, et al.
J Androl 2006 Sep

 

Injury and Poisoning

Effect of the CYP2D6*10 C188T polymorphism on postoperative tramadol analgesia in a Chinese population
Wang G, et al.
Eur J Clin Pharmacol 2006 Sep

 

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
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