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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
November 9, 2006
Volume 17, No. 19

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Genotype and allele frequency of human multidrug resistance (MDR1) gene C3435T polymorphism in Denizli province of Turkey
Turgut S, et al.
Mol Biol Rep 2006 Nov

LRRK2 G2019S founder haplotype in the Chinese population
Tan EK, et al.
Mov Disord 2006 Nov

 

Infectious and Parasitic Diseases

Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease
Jack DL, et al.
Clin Infect Dis 2006 Dec;43(11):1426-33

Haplotypes of IL6 and IL10 and Susceptibility to Human T Lymphotropic Virus Type I Infection among Children
Brown EE, et al.
J Infect Dis 2006 Dec;194(11):1565-9

Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis*
Walley KR & Russell JA
Crit Care Med 2006 Oct

           

 

Neoplasms

Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients
Lira MG, et al.
Exp Dermatol 2006 Dec;15(12):958-65

Variants of the hK2 Protein Gene (KLK2) Are Associated with Serum hK2 Levels and Predict the Presence of Prostate Cancer at Biopsy
Nam RK, et al.
Clin Cancer Res 2006 Nov;12(21):6452-8

The fibroblast growth factor receptor 4 (FGFR4) Arg(388) allele correlates with survival in head and neck squamous cell carcinoma
da Costa Andrade VC, et al.
Exp Mol Pathol 2006 Nov

The role of glutathione-S-transferase polymorphisms in ovarian cancer survival
Nagle CM, et al.
Eur J Cancer 2006 Nov

Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis
Huang Y, et al.
J Hum Genet 2006 Nov

Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
Abrahamson PE, et al.
Breast Cancer Res Treat 2006 Nov

Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis
Yang YC, et al.
Br J Cancer 2006 Nov

MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling
Wasielewski M, et al.
Breast Cancer Res Treat 2006 Nov

Genetic Variants of UGT1A6 Influence Risk of Colorectal Adenoma Recurrence
Hubner RA, et al.
Clin Cancer Res 2006 Nov;12(21):6585-9

hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese
Sakamoto T, et al.
J Epidemiol 2006 Nov;16(6):233-9

Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study
Mitrou PN, et al.
Carcinogenesis 2006 Nov

Tumor necrosis factor promoter gene polymorphism associated with increased susceptibility to non-Hodgkin's lymphomas
Bel Hadj Jrad B, et al.
Eur J Haematol 2006 Nov

A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer
Cybulski C, et al.
J Med Genet 2006 Nov;43(11):863-6

A large germline deletion in CHEK2 is associated with an increased risk of prostate cancer
Cybulski C, et al.
J Med Genet 2006 Oct

Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer
Darvishi K, et al.
Cancer Lett 2006 Oct

 

Endocrine, Nutritional and Metabolic Diseases

Genotype-by-nutrient interactions assessed in European obese women : A case-only study
Santos JL, et al.
Eur J Nutr 2006 Nov

Heteroduplex analysis for the three common HFE variants: methodology, reliablity and analysis of over 5000 requests for testing
Kingston J, et al.
J Clin Pathol 2006 Nov

Association of APOA5 c.553G>T polymorphism with type 2 diabetes mellitus in a Chinese population Zhai G, et al.
Clin Chem Lab Med 2006 Nov;44(11):1313-6

Association of C/T polymorphism in the LRP5 gene with circulating follicle stimulating hormone in white postmenopausal women
Zofkova I, et al.
Physiol Res 2006 Nov

Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians
Robitaille J, et al.
J Mol Med 2006 Nov

Putative association of RUNX1 polymorphisms with IgE levels in a Korean population
Chae SC, et al.
Exp Mol Med 2006 Oct;38(5):583-8

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7,342 Danish whites
Grarup N, et al.
J Clin Endocrinol Metab 2006 Oct

Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever
Ramasawmy R, et al.
Mol Immunol 2006 Oct

Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians
Au WY, et al.
J Gerontol A Biol Sci Med Sci 2006 Oct;61(10):1086-9

 

Mental Disorders

C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients
Hoenicka J, et al.
Acta Psychiatr Scand 2006 Dec;114(6):435-8

Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics
Nakajima M, et al.
J Hum Genet 2006 Nov

Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits
Gawlik M, et al.
BMC Psychiatry 2006 Nov;6(1):52

Alcoholism is associated with GALR3 but not two other galanin receptor genes
Belfer I, et al.
Genes Brain Behav 2006 Nov

Association of 4-Repeat Allele of the Dopamine D4 Receptor Gene Exon III Polymorphism and Response to Methylphenidate Treatment in Korean ADHD Children
Cheon KA, et al.
Neuropsychopharmacology 2006 Nov

Haplotype Spanning TTC12 and ANKK1, Flanked By the DRD2 and NCAM1 Loci, is Strongly Associated to Nicotine Dependence in Two Distinct American Populations
Gelernter J, et al.
Hum Mol Genet 2006 Nov

Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis
Li D & He L
Eur J Hum Genet 2006 Oct;14(10):1130-5

Apolipoprotein E Genotype Influences Presence and Severity of Delusions and Aggressive Behavior in Alzheimer Disease
van der Flier WM, et al.
Dement Geriatr Cogn Disord 2006 Oct;23(1):42-6

Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence
Samochowiec J, et al.
Neurosci Lett 2006 Oct

           

Diseases of the Nervous System and Sense Organs

Angiotensin-converting enzyme I/D gene polymorphism and risk of multiple sclerosis
Lovrecic L, et al.
Acta Neurol Scand 2006 Dec;114(6):374-7

A common A340T variant in PINK1 gene associated with late-onset Parkinson's disease in Chinese
Wang F, et al.
Neurosci Lett 2006 Nov

Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families
Gosso MF, et al.
Genes Brain Behav 2006 Nov;5(8):577-84

MECP2 and CDKL5 gene mutation analysis in Chinese patients with Rett syndrome
Li MR, et al.
J Hum Genet 2006 Nov

Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations
Schupbach M, et al.
Mov Disord 2006 Nov

Better Memory and Neural Efficiency in Young Apolipoprotein E {varepsilon}4 Carriers
Mondadori CR, et al.
Cereb Cortex 2006 Oct

Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease
Flex A, et al.
J Gerontol A Biol Sci Med Sci 2006 Oct;61(10):1065-9

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease
Ozturk A, et al.
Neurosci Lett 2006 Oct;406(3):265-9

 

Diseases of the Circulatory System

Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy
Sandrim VC, et al.
J Hypertens 2006 Dec;24(12):2393-7

{alpha}-Adducin Polymorphism, Atherosclerosis, and Cardiovascular and Cerebrovascular Risk
van Rijn MJ, et al.
Stroke 2006 Nov

Analysis of the XRCC1 gene as a modifier of the cerebral response in ischemic stroke
Dutra AV, et al.
BMC Med Genet 2006 Nov;7(1):78

Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism is associated with reduced risk for ischemic stroke with type 2 diabetes
Lee BC, et al.
Neurosci Lett 2006 Nov

A post-hoc analysis on the CD14 C(-260)T promoter polymorphism and coronary heart disease
Porsch-Ozcurumez M, et al.
Physiol Res 2006 Nov

Renal Haemodynamics are not Related to Genotypes in Offspring of Parents with Essential Hypertension
Skov K, et al.
J Renin Angiotensin Aldosterone Syst 2006 Mar;7(1):47-55

 

Diseases of the Respiratory System

Association study between the CX3CR1 gene and asthma
Tremblay K, et al.
Genes Immun 2006 Nov

Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study
Melen E, et al.
Clin Exp Allergy 2006 Nov;36(11):1391-8

 

Diseases of the Digestive System

Functional Polymorphisms in the Matrix Metalloproteinase-9 Gene in Relation to Severity of Chronic Periodontitis
Holla LI, et al.
J Periodontol 2006 Nov;77(11):1850-5

Effect of a Specific Cyclooxygenase-Gene Polymorphism (A-842G/C50T) on the Occurrence of Peptic Ulcer Hemorrhage
van Oijen MG, et al.
Dig Dis Sci 2006 Nov

 

Diseases of the Musculoskeletal System and Connective Tissue

HLA-DRB1*04 Alleles in Japanese Rheumatoid Arthritis Patients with AA Amyloidosis
Migita K, et al.
J Rheumatol 2006 Nov;33(11):2120-3

Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis
Wang CL, et al.
Osteoporos Int 2006 Nov

Methionine synthase reductase polymorphisms are associated with serum osteocalcin levels in postmenopausal women
Kim DJ, et al.
Exp Mol Med 2006 Oct;38(5):519-24

 

Congenital Anomalies

MTRR 66A>G polymorphism in relation to congenital heart defects
van Beynum IM, et al.
Clin Chem Lab Med 2006 Nov;44(11):1317-23

MTHFR 677C-->T and 1298A-->C Polymorphisms: Evaluation of Maternal Genotypic Risk and Association with Level of Neural Tube Defect
Dalal A, et al.
Gynecol Obstet Invest 2006 Nov;63(3):146-50

PVRL1 variants contribute to non-syndromic cleft lip and palate in multiple populations
Avila JR, et al.
Am J Med Genet A 2006 Nov

 

 

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Page last reviewed: June 8, 2007 (archived document)
Page last updated: November 2, 2007
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