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Case Study 5, Question 3: Correct Answer

Admit the patient and treat with IV quinidine plus doxycycline

In the presence of a diagnosis of malaria, species undetermined, in a patient returning from Zambia, the safest approach is to treat this as chloroquine-resistant P. falciparum. In addition, since the patient is slow in answering questions and signs of renal failure are present, it is best to treat this as a case of severe malaria. The patient should be given quinidine by intravenous infusion and doxycycline. (An additional argument for parenteral treatment is the patient’s vomiting.) Because of the potential cardiotoxicity of quinidine, the patient should be admitted to the intensive care unit to allow continuous monitoring of the ECG and frequent checks of the blood pressure. All possible efforts should be made to have as rapidly as possible a definitive identification of the malaria species, and a quantitative estimate of parasite density.

 

Page last modified : July 30, 2004
Content source: Division of Parasitic Diseases
National Center for Zoonotic, Vector-Borne, and Enteric Diseases (ZVED)

 

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