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Antiretroviral therapy in HIV-2-infected patients: changes in plasma
viral load, CD4+ cell counts, and drug resistance profiles of patients
treated in Abidjan, Cote d'Ivoire.
AIDS 2003; 17 (Suppl 3):S49-S54.
Adjé-Touré CA, Cheingsong R, Gerardo Garcìa-Lerma
J, Eholié S, Borget M-Y, Bouchez J-M, Otten RA, Maurice C, Sassan-Morokro
M, Ekpini RE, Nolan M, Chorba T, Heneine W, Nkengasong JN.
Abstract
OBJECTIVE: To describe changes in plasma viral load, CD4+ cell counts, and
drug resistance profiles of HIV-2-infected patients receiving antiretroviral
(ARV) therapy in Abidjan, Cote d'Ivoire. METHODS: Consecutive blood samples
were collected from 18 HIV-2-infected ARV-naive patients who had received
ARV therapy in the UNAIDS drug access initiative (UNAIDS-DAI) in Abidjan
between August 1998 and July 2000. Changes in HIV-2 plasma viral load, CD4+
cell counts, and genotypic and phenotypic drug resistance testing were determined.
RESULTS: At baseline, 11 (61%) of the 18 patients initiated highly active
antiretroviral therapy (HAART) and seven (39%) received dual therapy. No
significant change in median viral load was observed at 2 months (P = 0.09),
at 6 months (P = 0.06), and at 12 months of therapy (P = 0.26). No significant
increase in CD4+ cell counts was observed at 12 months (P = 0.10). All four
patients on indinavir-containing HAART had undetectable viral loads at 2-4
months of therapy. However, none of seven patients on nelfinavir-containing
HAART had a substantial decrease in viral load. Viruses from 14 patients
were analyzed, 12 of which (86%) had at least one primary resistance mutation
that is known to confer resistance to HIV-1 virus. Three patients had the
multi-drug-resistant mutation, Q151M, two of whom showed reduced susceptibility
to zidovudine, didanosine, stavudine and zalcitabine. CONCLUSION: Our limited
findings show that nelfinavir-containing regimens may have limited virologic
benefit to HIV-2-infected patients.