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Disease progression and survival with human immunodeficiency virus
type 1 (HIV-1) subtype E infection among female sex workers in Thailand.
Journal of Infectious Diseases 2000;181(5):1598-1606.
Kilmarx PH, Limpakarnjanarat K, Kaewkungwal J, Saisorn S, Uthaivoravit W,
Young NL, Mastro TD.
Abstract
This study describes rates and correlates of disease progression and survival
among 194 female sex workers in northern Thailand who were infected with
human immunodeficiency virus type 1 (HIV-1; 96% with subtype E). The median
rate of CD4 T lymphocyte decline (3.9 cells/microL/month), median time from
infection to <200 CD4 T lymphocytes/microL (6.9 years), and time to 25%
mortality (6.0 years) were similar to those found in studies performed in
Western countries before highly active antiretroviral therapy was available
to populations infected with HIV-1 subtype B. Mortality rates among women
with >100,000 HIV-1 RNA copies/mL were 15.4 times higher (95% confidence
interval, 5.2-45.2) than among women with <10,000 copies. Initial CD4
T lymphocyte counts and serum virus load were independently strong predictors
of survival. These results can help in assessing the effects of the epidemic
in Thailand and in determining the prognoses for individual patients.