Syndrome	Absolute Risk in Mutation Carriers
aSee text on Lynch syndrome for a full discussion of risk.
Familial Adenomatous Polyposis (FAP)	90% by age 45 years [1]
Attenuated FAP	69% by age 80 years [2]
Lynch syndrome	80% by age 75 yearsa [3]
MYH-Associated Neoplasia	Not established
Peutz-Jeghers syndrome	39% by age 70 years [4]
Juvenile Polyposis syndrome	17% to 68% by age 60 years [5,6]

References

1. Bussey HJ: Familial Polyposis Coli: Family Studies, Histopathology, Differential Diagnosis, and Results of Treatment. Baltimore, Md: The Johns Hopkins University Press, 1975. 
   
   
2. Burt RW, Leppert MF, Slattery ML, et al.: Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology 127 (2): 444-51, 2004.  [PUBMED Abstract]
   
   
3. Vasen HF, Wijnen JT, Menko FH, et al.: Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 110 (4): 1020-7, 1996.  [PUBMED Abstract]
   
   
4. Hearle N, Schumacher V, Menko FH, et al.: Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res 12 (10): 3209-15, 2006.  [PUBMED Abstract]
   
   
5. Coburn MC, Pricolo VE, DeLuca FG, et al.: Malignant potential in intestinal juvenile polyposis syndromes. Ann Surg Oncol 2 (5): 386-91, 1995.  [PUBMED Abstract]
   
   
6. Desai DC, Neale KF, Talbot IC, et al.: Juvenile polyposis. Br J Surg 82 (1): 14-7, 1995.  [PUBMED Abstract]