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IRIS Toxicological Review of Propionaldehyde (External Review Draft)
Federal Register Notices
Contact
- John J. Stanek
- by phone at: 919-541-1048
- by fax at: 919-541-0245
- by email at: stanek.john@epa.gov
- by fax at: 919-541-0245
Notice
EPA announces the release of the Toxicological Review of Propionaldehyde in the March 6, 2008 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within the external review period (next 45 days) will be provided to peer reviewers prior to the External Peer Review Panel Meeting for their consideration. Any comments not received within the requested time period will be considered by EPA in their future revisions.
EPA announced in a May 2, 2008 Federal Register Notice that the external peer review meeting will be held May 29, 2008.
Background
Propionaldehyde is a colorless liquid with a suffocating, fruity odor. It is used in the manufacturing of propionic acid and polyvinyl and other plastics, in the synthesis of rubber chemicals, and as a disinfectant and preservative.
The chemical is released to the environment primarily through the combustion of wood, gasoline, diesel fuel, and polyethylene. Propionaldehyde is also a component of cigarette smoke and a food additive/flavoring agent. Although no studies on the effects of propionaldehyde administered by the oral route have been performed, based on its expected daily intake (below 1800 µg/day) and eventual metabolism in the citric acid cycle, it does not appear to be a safety concern for public health via ingestion (USFDA, WHO/JECFA). Thus, the most probable route of exposure of concern to the general population is by inhalation. The assessment will present reference values for the noncancer effects of propionaldehyde (RfD and RfC), where supported by available data, and a cancer assessment.
History/Chronology
| 2000 - 2001 | Propionaldehyde was nominated by OAR in 2000 and 2001 and by OAQPS in 2003 as a chemical listed for monitoring under the Clean Air Act. |
| Feb 2008 | EPA releases the external review draft for public comment and review. |
Next Steps
Downloads/Related Links
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Propionaldehyde: in Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF) (59 pp, 415 KB, about PDF)
- Charge to External Peer Reviewers (PDF) (3 pp, 21 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (33 pp, 186 KB, about PDF)
Related Link(s)
- Union Carbide Study (PDF) (372 pp, 10 MB, about PDF)
- External Peer Review of Union Carbide Study (PDF) (19 pp, 82 KB, about PDF)
Additional Information
Citation
