Jump to main content.


IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft)

Contact
Susan H. Rieth
by phone at:   703-347-8582
by email at:  rieth.susan@epa.gov

Notice

EPA announces the release of the Toxicological Review of Carbon Tetrachloride (External Review Draft) in the May 21, 2008 Federal Register. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of carbon tetrachloride that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
Background
Carbon tetrachloride has been used as a dry-cleaning agent, fabric-spotting fluid, solvent, reagent in chemical synthesis, fire extinguisher fluid, and grain fumigant, but its primary use was in chlorofluorocarbon (CFC) production. Production of this chemical peaked in the early 1970s; annual production has generally declined since the mid-1970s. The Consumer Product Safety Commission banned the use of carbon tetrachloride in consumer products in the 1970s. Decline in the use of carbon tetrachloride also accompanied EPA’s increased regulation of the use of CFCs in propellants, and the Montreal Protocol, which was implemented in the U.S. via Title VI of the Clean Air Act Amendments of 1990 and that called for a ban (with certain exemptions) on production and import of carbon tetrachloride.

History/Chronology

1987EPA posts the Carbon Tetrachloride IRIS assessment on the IRIS database (RfD and cancer assessment)
May 2008EPA releases the draft document for an external peer review.
Jun 2008EPA announces the July 16 Public Listening Session in a June 24, 2008 Federal Register Notice.
Sep 2008EPA announces the October 14 External Peer Review Meeting in a September 9, 2008 Federal Register Notice.

Next Steps

Following the External Peer Review, the final assessment will be published on the IRIS database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2008-0058” (for the docket ID) to comment on this report.

Contact Information

Susan Rieth
            by phone at:  703-347-8582
            by fax at:  703-347-8699
            by email at:  rieth.susan@epa.gov

Reeder Sams
            by phone at:  919-541-0661
            by fax at:  919-541-0245
            by email at:  sams.reeder@epa.gov

Citation

U.S. EPA. IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/005A.
Email a link to this page to a friend

ORD Home | Search EPA | Satisfaction Questionnaire


Local Navigation


Jump to main content.