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Stage II Endometrial Cancer
Stage IIA
Stage IIB
Current Clinical Trials
Many combinations of preoperative intracavitary and external-beam radiation
therapy (EBRT) with hysterectomy and bilateral salpingo-oophorectomy are used for
treatment of stage II endometrial cancer, with careful biopsy of the
para-aortic nodes at the time of surgery. When microscopic cervical stromal
involvement is found, postoperative radiation therapy (EBRT and vaginal
radiation therapy) should be used.
Stage IIA
Stage IIA (endocervical glandular involvement only) should be treated the same
as stage I disease.
Stage IIB
Standard treatment options:
- Hysterectomy, bilateral salpingo-oophorectomy, and node sampling followed by
postoperative radiation therapy.
- Preoperative intracavitary and EBRT followed by
hysterectomy and bilateral salpingo-oophorectomy. (A biopsy of the para-aortic
nodes should be done at the time of surgery.)
- Radical hysterectomy and pelvic lymphadenectomy in selected cases.
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II endometrial carcinoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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