National Institute of Allergy and Infectious Diseases
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Biodefense and Related Programs
 Biodefense
 Radiation Countermeasures
 Chemical Countermeasures
  Introduction
  Research History
  Research Strategy
  Achievements and Goals
  Research Areas
   Cellular Respiration
   Nervous System
   Respiratory Tract
    Chemicals Affecting the Respiratory Tract
    Current Medical Countermeasures
    Potential Medical Countermeasures
    Short-Term Goals
    Long-Term Goals
   Skin, Eyes, and Mucous Membranes


Medical Countermeasures Against Chemical Threats

Respiratory Tract

Current Medical Countermeasures

Pretreatment and Post-Exposure Treatment

Specific pretreatments, drugs to prevent chemically induced lung injuries due to respiratory airway toxins, are not available. Analgesic medications, oxygen, humidification, and ventilator support currently constitute standard therapy. Hemorrhaging, signifying substantial damage to the lining of the airways and lungs, can occur with exposure to highly corrosive chemicals and may require additional medical interventions. Treatment of injuries to the lower respiratory tract is also supportive and usually includes administration of oxygen, the use of mechanical ventilation to include positive airway pressure, and bronchodilators to treat bronchospasms. Drugs that reduce the inflammatory response, promote healing of tissues, and prevent the onset of pulmonary edema or secondary inflammation may be used following severe injury to prevent chronic scarring and airway narrowing.

Diagnosis

Current diagnostic capabilities are limited. Exposure to chlorine, phosgene, or any of the major alkalis is determined based on clinical signs and symptoms. No screening tests are available to identify individuals exposed to low levels of chemicals.


See Also

NIH Strategic Plan and Research Agenda for Medical Countermeasures Against Chemical Threats (PDF 3 MB)

Biodefense and Related Programs—The NIAID Biodefense Web site includes biodefense-related information for biomedical researchers, the public, and the media.

View a list of links for more information about Medical Countermeasures Against Chemical Threats

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See Also

NIH Strategic Plan and Research Agenda for Medical Countermeasures Against Chemical Threats (PDF 3 MB)

Biodefense and Related Programs—The NIAID Biodefense Web site includes biodefense-related information for biomedical researchers, the public, and the media.

View a list of links for more information about Medical Countermeasures Against Chemical Threats