Davis I, Leibel J, Paroski P, Morgan A, Norris B; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 403 (abstract no. W.B.P.307).
Woodhull Medical and Mental Health Center, Brooklyn, NY, USA
OBJECTIVE: To use disulfiram in treatment for HIV seropositive asymptomatic patients and explore if there is a significant correlative change between T4/T8 ratio and/or absolute T4 count. METHOD: Seropositive patients with T4/T8 ratios less than 1.20 or absolute T4 counts less than 500 were started on disulfiram - a split weekly dosage of 1000 mg. T4/T8 counts and ratios were followed every three months for a period of six months. Pre- treatment and post-treatment differences were evaluated by the student T test. RESULTS: In a sample of 10 patients on disulfiram alone, a comparison of initial and nine month followup in the ratio of T4/T8 cells, absolute T4 and absolute T8 counts reveals a statistically significant improvement at the .05 level with a one sided T test. Of these 10 patients, 8 had documented improvement in T4/T8 ratio. Assuming a population probability of .5 the power to detect a difference is less than 50%. Graph and data will be presented. CONCLUSION: Although the sample size is small, a statistically significant difference was noted in seropositive patients on disulfiram treatment. These results suggest a large scale study of disulfiram should be initiated to further delineate the treatment effect.
Publication Types:
Keywords:
- CD8-Positive T-Lymphocytes
- HIV Infections
- HIV Seropositivity
- Humans
- T-Lymphocytes, Cytotoxic
- therapy
Other ID:
UI: 102177940
From Meeting Abstracts